Gene name:
NPFFR2 (GPR74;NPFF2;NPGPR) ;
Protein name:
Neuropeptide FF receptor 2 ;
Alternative:
G-protein coupled receptor HLWAR77 ;G-protein coupled receptor 74 ;Neuropeptide G-protein coupled receptor ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MNSFFGTPAA | SWCLLESDVS | SAPDKEAGRE | RRALSVQQRG | GPAWSGSLEW |
100:
SRQSAGDRRR | LGLSRQTAKS | SWSRSRDRTC | CCRRAWWILV | PAADRARRER |
150:
FIMNEKWDTN | SSENWHPIWN | VNDTKHHLYS | DINITYVNYY | LHQPQVAAIF |
200:
IISYFLIFFL | CMMGNTVVCF | IVMRNKHMHT | VTNLFILNLA | ISDLLVGIFC |
250:
MPITLLDNII | AGWPFGNTMC | KISGLVQGIS | VAASVFTLVA | IAVDRFQCVV |
300:
YPFKPKLTIK | TAFVIIMIIW | VLAITIMSPS | AVMLHVQEEK | YYRVRLNSQN |
350:
KTSPVYWCRE | DWPNQEMRKI | YTTVLFANIY | LAPLSLIVIM | YGRIGISLFR |
400:
AAVPHTGRKN | QEQWHVVSRK | KQKIIKMLLI | VALLFILSWL | PLWTLMMLSD |
450:
YADLSPNELQ | IINIYIYPFA | HWLAFGNSSV | NPIIYGFFNE | NFRRGFQEAF |
500:
QLQLCQKRAK | PMEAYALKAK | SHVLINTSNQ | LVQESTFQNP | HGETLLYRKS |
522:
AEKPQQELVM | EELKETTNSS | EI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Neuropeptide FF receptor 2
ELISA Kit for Human Neuropeptide FF receptor 2
ELISA Kit for Human Neuropeptide FF receptor 2
CLIA Kit for Human Neuropeptide FF receptor 2
CLIA Kit for Human Neuropeptide FF receptor 2
CLIA Kit for Human Neuropeptide FF receptor 2
Polyclonal Antibody for Human Neuropeptide FF receptor 2
Polyclonal Antibody for Human Neuropeptide FF receptor 2
Polyclonal Antibody for Human Neuropeptide FF receptor 2
Monoclonal Antibody for Human Neuropeptide FF receptor 2
Monoclonal Antibody for Human Neuropeptide FF receptor 2
Monoclonal Antibody for Human Neuropeptide FF receptor 2
Protein for Human Neuropeptide FF receptor 2
Protein for Human Neuropeptide FF receptor 2
Protein for Human Neuropeptide FF receptor 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Fetus .
2.
"Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor."
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CHARACTERIZATION
tissue :
Brain .
3.
"Identification and characterization of two G protein-coupled receptors for neuropeptide FF."
Bonini J.A.
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Jones K.A.
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Adham N.
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Forray C.
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Artymyshyn R.
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Durkin M.M.
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Smith K.E.
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Tamm J.A.
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Lakhlani P.P.
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J. Biol. Chem.275:39324-39331(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CHARACTERIZATION
tissue :
Spinal cord .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
5.
"Identification and characterization of two cognate receptors for mammalian FMRFamide-like neuropeptides."
Liu Q.
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Guan X.-M.
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McDonald T.P.
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Jiang Q.
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Zeng Z.
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Marlene J.
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Williams D.L. Jr.
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Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)