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Index > Protein center > NQO1(Gene name) > Human
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  • NQO1 (Gene name),
  • NAD(P)H dehydrogenase [quinone] 1 (Protein name ),  NQO1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NQO1(DIA4;NMOR1);
    Protein name:
    NAD(P)H dehydrogenase [quinone] 1;
    Alternative:
    DT-diaphorase(DTD);Azoreductase;NAD(P)H:quinone oxidoreductase 1;Menadione reductase;Quinone reductase 1(QR1);Phylloquinone reductase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    274
    Sequence:
    50:
    MVGRRALIVL | AHSERTSFNY | AMKEAAAAAL | KKKGWEVVES | DLYAMNFNPI | 
    100:
    ISRKDITGKL | KDPANFQYPA | ESVLAYKEGH | LSPDIVAEQK | KLEAADLVIF | 
    150:
    QFPLQWFGVP | AILKGWFERV | FIGEFAYTYA | AMYDKGPFRS | KKAVLSITTG | 
    200:
    GSGSMYSLQG | IHGDMNVILW | PIQSGILHFC | GFQVLEPQLT | YSIGHTPADA | 
    250:
    RIQILEGWKK | RLENIWDETP | LYFAPSSLFD | LNFQAGFLMK | KEVQDEEKNK | 
    274:
    KFGLSVGHHL | GKSIPTDNQI | KARK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    KEGG:
    MIM:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    E2154h
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    MSDS:
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    96T
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    ELISA Kit for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    E2154r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    E2154m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    U2154h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    U2154r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    U2154m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    P2154Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    P2154Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1
    Cat.:
    P2154Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1
    Monoclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1
    Monoclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1
    Protein for Human NAD(P)H dehydrogenase [quinone] 1
    Protein for Human NAD(P)H dehydrogenase [quinone] 1
    Protein for Human NAD(P)H dehydrogenase [quinone] 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16."
      Jaiswal A.K. , McBride O.W. , Adesnik M. , Nebert D.W.
      J. Biol. Chem.263:13572-13578(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    2. 2.
      "Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin."
      Jaiswal A.K.
      Biochemistry30:10647-10653(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      NIEHS SNPs program
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-187
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT SER-187
      tissue: Amygdala.
    5. 5.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)."
      Skelly J.V. , Sanderson M.R. , Suter D.A. , Baumann U. , Read M.A. , Gregory D.S.J. , Bennett M. , Hobbs S.M. , Neidle S.
      J. Med. Chem.42:4325-4330(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 4-274 IN COMPLEX WITH FAD;SUBUNIT
    10. 10.
      "Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release."
      Faig M. , Bianchet M.A. , Talalay P. , Chen S. , Winski S. , Ross D. , Amzel L.M.
      Proc. Natl. Acad. Sci. U.S.A.97:3177-3182(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH FAD AND DUROQUINONE
    11. 11.
      "Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches."
      Winski S.L. , Faig M. , Bianchet M.A. , Siegel D. , Swann E. , Fung K. , Duncan M.W. , Moody C.J. , Amzel L.M. , Ross D.
      Biochemistry40:15135-15142(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH FAD AND THE INHIBITOR ES936;MASS SPECTROMETRY
    12. 12.
      "Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones."
      Faig M. , Bianchet M.A. , Winski S. , Hargreaves R. , Moody C.J. , Hudnott A.R. , Ross D. , Amzel L.M.
      Structure9:659-667(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEXES WITH FAD AND INHIBITORS;SUBUNIT
    13. 13.
      "The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol."
      Asher G. , Dym O. , Tsvetkov P. , Adler J. , Shaul Y.
      Biochemistry45:6372-6378(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR DICOUMAROL
    14. 14.
      "NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity."
      Traver R.D. , Horikoshi T. , Danenberg K.D. , Stadlbauer T.H. , Danenberg P.V. , Ross D. , Gibson N.W.
      Cancer Res.52:797-802(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-187
    15. 15.
      "No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population."
      Kristiansen O.P. , Larsen Z.M. , Johannesen J. , Nerup J. , Mandrup-Poulsen T. , Pociot F.
      Hum. Mutat.14:67-70(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-187
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