NQO1 ELISA Kit for Human(Homo sapiens) | EIAab.comNQO1 ELISA Kit for Human(Homo sapiens)

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NQO1 (Gene name),

NAD(P)H dehydrogenase [quinone] 1 (Protein name ), NQO1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NQO1(DIA4;NMOR1);

Protein name:

NAD(P)H dehydrogenase [quinone] 1;

Alternative:

DT-diaphorase(DTD);Azoreductase;NAD(P)H:quinone oxidoreductase 1;Menadione reductase;Quinone reductase 1(QR1);Phylloquinone reductase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

274

Sequence:

50:

100:

150:

200:

250:

274:

KFGLSVGHHL | GKSIPTDNQI | KARK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000319788

Pfam:

PF02525

UniGene:

Hs.406515

KEGG:

hsa:1728

MIM:

125860

String:

P15559

SMR:

P15559

Uniprot:

P15559

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ELISA Kit for Human NAD(P)H dehydrogenase [quinone] 1

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E2154h

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96T

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ELISA Kit for Human NAD(P)H dehydrogenase [quinone] 1

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E2154r

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96T

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ELISA Kit for Human NAD(P)H dehydrogenase [quinone] 1

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E2154m

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96T

CLIA Kit for Human NAD(P)H dehydrogenase [quinone] 1

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U2154h

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96T

CLIA Kit for Human NAD(P)H dehydrogenase [quinone] 1

Cat.:

U2154r

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96T

CLIA Kit for Human NAD(P)H dehydrogenase [quinone] 1

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U2154m

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96T

Polyclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1

Cat.:

P2154Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1

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P2154Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1

Cat.:

P2154Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human NAD(P)H dehydrogenase [quinone] 1

Protein for Human NAD(P)H dehydrogenase [quinone] 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16."
Jaiswal A.K. , McBride O.W. , Adesnik M. , Nebert D.W.
J. Biol. Chem.263:13572-13578(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin."
Jaiswal A.K.
Biochemistry30:10647-10653(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

NIEHS SNPs program
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-187
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT SER-187
tissue: Amygdala.
5.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
8.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.

"Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)."
Skelly J.V. , Sanderson M.R. , Suter D.A. , Baumann U. , Read M.A. , Gregory D.S.J. , Bennett M. , Hobbs S.M. , Neidle S.
J. Med. Chem.42:4325-4330(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 4-274 IN COMPLEX WITH FAD;SUBUNIT
10.

"Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release."
Faig M. , Bianchet M.A. , Talalay P. , Chen S. , Winski S. , Ross D. , Amzel L.M.
Proc. Natl. Acad. Sci. U.S.A.97:3177-3182(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH FAD AND DUROQUINONE
11.

"Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches."
Winski S.L. , Faig M. , Bianchet M.A. , Siegel D. , Swann E. , Fung K. , Duncan M.W. , Moody C.J. , Amzel L.M. , Ross D.
Biochemistry40:15135-15142(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH FAD AND THE INHIBITOR ES936;MASS SPECTROMETRY
12.

"Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones."
Faig M. , Bianchet M.A. , Winski S. , Hargreaves R. , Moody C.J. , Hudnott A.R. , Ross D. , Amzel L.M.
Structure9:659-667(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEXES WITH FAD AND INHIBITORS;SUBUNIT
13.

"The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol."
Asher G. , Dym O. , Tsvetkov P. , Adler J. , Shaul Y.
Biochemistry45:6372-6378(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR DICOUMAROL
14.

"NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity."
Traver R.D. , Horikoshi T. , Danenberg K.D. , Stadlbauer T.H. , Danenberg P.V. , Ross D. , Gibson N.W.
Cancer Res.52:797-802(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-187
15.

"No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population."
Kristiansen O.P. , Larsen Z.M. , Johannesen J. , Nerup J. , Mandrup-Poulsen T. , Pociot F.
Hum. Mutat.14:67-70(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-187

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