NR1H4 ELISA Kit for Human(Homo sapiens) | EIAab.comNR1H4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NR1H4(Gene name) > Human

NR1H4 (Gene name),

Bile acid receptor (Protein name ), NR1H4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

NR1H4(BAR;FXR;HRR1;RIP14);

Protein name:

Bile acid receptor;

Alternative:

Farnesol receptor HRR-1;Farnesoid X-activated receptor;Retinoid X receptor-interacting protein 14(RXR-interacting protein 14);Nuclear receptor subfamily 1 group H member 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2 (By similarity). Interacts with CARM1 and SMARD1.

Function:

Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

486

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

486:

LTELRTFNHH | HAEMLMSWRV | NDHKFTPLLC | EIWDVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:9971

STRING:

9606.ENSP00000315442

UniGene:

Hs.282735

MIM:

603826

Pfam:

PF00104

SMR:

Q96RI1

String:

Q96RI1

Uniprot:

Q96RI1

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ELISA Kit for Human Bile acid receptor

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E2042h

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96T

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ELISA Kit for Human Bile acid receptor

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E2042r

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96T

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ELISA Kit for Human Bile acid receptor

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E2042m

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96T

ELISA Kit for Human Bile acid receptor

Cat.:

E2042b

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96T

CLIA Kit for Human Bile acid receptor

Cat.:

U2042b

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96T

CLIA Kit for Human Bile acid receptor

Cat.:

U2042r

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96T

CLIA Kit for Human Bile acid receptor

Cat.:

U2042m

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96T

CLIA Kit for Human Bile acid receptor

Cat.:

U2042h

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96T

Polyclonal Antibody for Human Bile acid receptor

Cat.:

P2042Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Bile acid receptor

Cat.:

P2042Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Bile acid receptor

Cat.:

P2042Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Bile acid receptor

Protein for Human Bile acid receptor

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"The identification of the cDNA coding for HRR-1, a novel human farnesol receptor."
Papetti M. , Wood N. , Lohmar P.D. , Bowman M.R.
Submitted (1996-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
2.

"Functional analysis of human farnesol receptor (NR1H4) splicing variant."
Han J.-I. , Bok S.-H. , Jeong T.-S.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
3.

"Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters."
Huber R.M. , Murphy K. , Miao B. , Link J.R. , Cunningham M.R. , Rupar M.J. , Gunyuzlu P.L. , Haws T.F. Jr. , Kassam A. , Powell F. , Hollis G.F. , Young P.R. , Mukherjee R. , Burn T.C.
Gene290:35-43(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
5.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5)
8.

"Identification of a nuclear receptor for bile acids."
Makishima M. , Okamoto A.Y. , Repa J.J. , Tu H. , Learned R.M. , Luk A. , Hull M.V. , Lustig K.D. , Mangelsdorf D.J. , Shan B.
Science284:1362-1365(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Bile acids: natural ligands for an orphan nuclear receptor."
Parks D.J. , Blanchard S.G. , Bledsoe R.K. , Chandra G. , Consler T.G. , Kliewer S.A. , Stimmel J.B. , Willson T.M. , Zavacki A.M. , Moore D.D. , Lehmann J.M.
Science284:1365-1368(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis."
Holt J.A. , Luo G. , Billin A.N. , Bisi J. , McNeill Y.Y. , Kozarsky K.F. , Donahee M. , Wang D.Y. , Mansfield T.A. , Kliewer S.A. , Goodwin B. , Jones S.A.
Genes Dev.17:1581-1591(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."
Hsiao P.W. , Fryer C.J. , Trotter K.W. , Wang W. , Archer T.K.
Mol. Cell. Biol.23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMARD1
12.

"Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1."
Ananthanarayanan M. , Li S. , Balasubramaniyan N. , Suchy F.J. , Walsh M.J.
J. Biol. Chem.279:54348-54357(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CARM1
13.

"Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes."
Balasubramaniyan N. , Ananthanarayanan M. , Suchy F.J.
Am. J. Physiol.302:G937-G947(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-220 BY SETD7
14.

"A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR."
Downes M. , Verdecia M.A. , Roecker A.J. , Hughes R. , Hogenesch J.B. , Kast-Woelbern H.R. , Bowman M.E. , Ferrer J.L. , Anisfeld A.M. , Edwards P.A. , Rosenfeld J.M. , Alvarez J.G. , Noel J.P. , Nicolaou K.C. , Evans R.M.
Mol. Cell11:1079-1092(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 258-476 IN COMPLEX WITH SYNTHETIC AGONIST FEXARAMINE;FUNCTION;INTERACTION WITH NCOA1
15.

"Structural basis for bile acid binding and activation of the nuclear receptor FXR."
Mi L.Z. , Devarakonda S. , Harp J.M. , Han Q. , Pellicciari R. , Willson T.M. , Khorasanizadeh S. , Rastinejad F.
Mol. Cell11:1093-1100(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 241-469 IN COMPLEXES WITH CHENODEOXYCHOLIC ACID ANALOGS AND NCOA2 COACTIVATOR PEPTIDE
16.

"Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064."
Akwabi-Ameyaw A. , Bass J.Y. , Caldwell R.D. , Caravella J.A. , Chen L. , Creech K.L. , Deaton D.N. , Jones S.A. , Kaldor I. , Liu Y. , Madauss K.P. , Marr H.B. , McFadyen R.B. , Miller A.B. , Iii F.N. , Parks D.J. , Spearing P.K. , Todd D. , more...
Bioorg. Med. Chem. Lett.18:4339-4343(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 252-486 IN COMPLEX WITH SYNTHETIC AGONIST;FUNCTION;INTERACTION WITH NCOA1
17.

"Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation."
Soisson S.M. , Parthasarathy G. , Adams A.D. , Sahoo S. , Sitlani A. , Sparrow C. , Cui J. , Becker J.W.
Proc. Natl. Acad. Sci. U.S.A.105:5337-5342(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 249-486 IN COMPLEX WITH STEROID ANALOG MFA-1 AND NCOA1 PEPTIDE;INTERACTION WITH NCOA1;DOMAIN
18.

"Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064."
Bass J.Y. , Caldwell R.D. , Caravella J.A. , Chen L. , Creech K.L. , Deaton D.N. , Madauss K.P. , Marr H.B. , McFadyen R.B. , Miller A.B. , Parks D.J. , Todd D. , Williams S.P. , Wisely G.B.
Bioorg. Med. Chem. Lett.19:2969-2973(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 260-486 IN COMPLEX WITH SYNTHETIC AGONIST;FUNCTION;INTERACTION WITH NCOA1
19.

"FXR agonist activity of conformationally constrained analogs of GW 4064."
Akwabi-Ameyaw A. , Bass J.Y. , Caldwell R.D. , Caravella J.A. , Chen L. , Creech K.L. , Deaton D.N. , Madauss K.P. , Marr H.B. , McFadyen R.B. , Miller A.B. , Navas F. III , Parks D.J. , Spearing P.K. , Todd D. , Williams S.P. , Bruce Wisely G.
Bioorg. Med. Chem. Lett.19:4733-4739(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 257-486 IN COMPLEX WITH SYNTHETIC AGONIST;FUNCTION;INTERACTION WITH NCOA1
20.

"Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR)."
Flatt B. , Martin R. , Wang T.L. , Mahaney P. , Murphy B. , Gu X.H. , Foster P. , Li J. , Pircher P. , Petrowski M. , Schulman I. , Westin S. , Wrobel J. , Yan G. , Bischoff E. , Daige C. , Mohan R.
J. Med. Chem.52:904-907(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 258-486 IN COMPLEX WITH SYNTHETIC AGONIST
21.

"Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates."
Lundquist J.T. , Harnish D.C. , Kim C.Y. , Mehlmann J.F. , Unwalla R.J. , Phipps K.M. , Crawley M.L. , Commons T. , Green D.M. , Xu W. , Hum W.T. , Eta J.E. , Feingold I. , Patel V. , Evans M.J. , Lai K. , Borges-Marcucci L. , Mahaney P.E. , more...
J. Med. Chem.53:1774-1787(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 248-476 IN COMPLEX WITH SYNTHETIC AGONIST

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