NRG1 ELISA Kit for Human(Homo sapiens) | EIAab.comNRG1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NRG1(Gene name) > Human

NRG1 (Gene name),

Pro-neuregulin-1, membrane-bound isoform (Protein name ), NRG1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

NRG1(GGF;HGL;HRGA;NDF;SMDF);

Protein name:

Pro-neuregulin-1, membrane-bound isoform(Pro-NRG1);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The cytoplasmic domain interacts with the LIM domain region of LIMK1.

Function:

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Subcellular Location:

Isoform 10 Membrane Single-pass type I membrane protein May possess an internal uncleaved signal sequence.

Protein Attributes:

Sequence length:

640

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

640:

ATPAFRLADS | RTNPAGRFST | QEEIQARLSS | VIANQDPIAV |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

142445

KEGG:

hsa:3084

Pfam:

PF07679

String:

Q02297

Pfam:

PF12661

UniGene:

Hs.453951

SMR:

Q02297

Uniprot:

Q02297

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ELISA Kit for Human Pro-NRG1

Cat.:

E1866h

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96T

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ELISA Kit for Human Pro-NRG1

Cat.:

E1866r

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96T

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ELISA Kit for Human Pro-NRG1

Cat.:

E1866c

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96T

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CLIA Kit for Human Pro-NRG1

Cat.:

U1866r

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96T

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CLIA Kit for Human Pro-NRG1

Cat.:

U1866h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human Pro-NRG1

Cat.:

U1866c

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96T

Polyclonal Antibody for Human Pro-NRG1

Cat.:

P1866Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Pro-NRG1

Cat.:

P1866Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Pro-NRG1

Protein for Human Pro-NRG1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome"

Ji Fei Zhang , Fu Sheng Zhao, Geng Wu, Qing Fei Kong, Bo Sun, Jingyan Cao, Yao Zhang, Jing Hua Wang, Jing Zhang, Xu Dong Jin , Hu Lun Li

From:Neuroscience Letters

[2].

"Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome"

JF Zhang, FS Zhao, G Wu, et al.

From:Neuroscience letters

References

1.

"Identification of heregulin, a specific activator of p185erbB2."
Holmes W.E. , Sliwkowski M.X. , Akita R.W. , Henzel W.J. , Lee J. , Park J.W. , Yansura D. , Abadi N. , Raab H. , Lewis G.D. , Shepard H.M. , Kuang W.-J. , Wood W.I. , Goeddel D.V. , Vandlen R.L.
Science256:1205-1210(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6; 7 AND 8);PARTIAL PROTEIN SEQUENCE
2.

"Structural and functional aspects of the multiplicity of Neu differentiation factors."
Wen D. , Suggs S.V. , Karunagaran D. , Liu N. , Cupples R.L. , Luo Y. , Janssen A.M. , Ben-Baruch N. , Trollinger D.B. , Jacobsen V.L. , Meng S.-Y. , Lu H.S. , Hu S. , Chang D. , Yang W. , Yanigahara D. , Koski R.A. , Yarden Y.
Mol. Cell. Biol.14:1909-1919(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 6; 7 AND 8)
tissue: Kidney adenocarcinoma.
tissue: Pituitary.
3.

"Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system."
Marchionni M.A. , Goodearl A.D.J. , Chen M.S. , Bermingham-McDonogh O. , Kirk C. , Hendricks M. , Danehy F. , Misumi D. , Sudhalter J. , Kobayashi K. , Wroblewski D. , Lynch C. , Baldasarre M. , Hiles I. , Davis J.B. , Hsuan J.J. , Totty N.F. , Otsu M. , more...
Nature362:312-318(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9)
tissue: Brain.
4.

"Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons."
Ho W.-H. , Armanini M.P. , Nuijens A. , Phillips H.S. , Osheroff P.L.
J. Biol. Chem.270:14523-14532(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10)
tissue: Brain stem.
tissue: Cerebellum.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 10 AND 12);VARIANT THR-289
tissue: Hippocampus.
6.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175."
Schaefer G. , Fitzpatrick V.D. , Sliwkowski M.X.
Oncogene15:1385-1394(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF GAMMA-HEREGULIN FUSION PROTEIN
tissue: Mammary cancer.
9.

"Neuregulin 1 and susceptibility to Schizophrenia."
Stefansson H. , Sigurdsson E. , Steinthorsdottir V. , Bjornsdottir S. , Sigmundsson T. , Ghosh S. , Brynjolfsson J. , Gunnarsdottir S. , Ivarsson O. , Chou T.T. , Hjaltason O. , Birgisdottir B. , Jonsson H. , Gudnadottir V.G. , Gudmundsdottir E. , Bjornsson A. , Ingvarsson B. , Ingason A. , more...
Am. J. Hum. Genet.71:877-892(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 8 AND 9);SUSCEPTIBILITY TO SCHIZOPHRENIA
10.

"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia."
Tan W. , Wang Y. , Gold B. , Chen J. , Dean M. , Harrison P.J. , Weinberger D.R. , Law A.J.
J. Biol. Chem.282:24343-24351(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11);ALTERNATIVE SPLICING;VARIANTS GLN-38 AND THR-289;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
tissue: Hippocampus.
tissue: Prefrontal cortex.
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 10)
tissue: Brain.
tissue: Duodenum.
12.

Schoumacher F. , Herzer S. , Flury N. , Kueng W. , Mueller H. , Eppenberger U.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-211 (ISOFORM 1)
13.

"Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor."
Culouscou J.-M. , Plowman G.D. , Carlton G.W. , Green J.M. , Shoyab M.
J. Biol. Chem.268:18407-18410(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-28
14.

"Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells."
Peles E. , Bacus S.S. , Koski R.A. , Lu H.S. , Wen D. , Ogden S.G. , Levy R.B. , Yarden Y.
Cell69:205-216(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE (ISOFORM 1);FUNCTION;GLYCOSYLATION
15.

"Heregulin induces tyrosine phosphorylation of HER4/p180erbB4."
Plowman G.D. , Green J.M. , Culouscou J.M. , Carlton G.W. , Rothwell V.M. , Buckley S.
Nature366:473-475(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB4;FUNCTION
16.

"Gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line."
Wang X.-Z. , Jolicoeur E.M. , Conte N. , Chaffanet M. , Zhang Y. , Mozziconacci M.-J. , Feiner H. , Birnbaum D. , Pebusque M.-J. , Ron D.
Oncogene18:5718-5721(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION
17.

"Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation."
Liu X. , Baker E. , Eyre H.J. , Sutherland G.R. , Zhou M.
Oncogene18:7110-7114(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION
18.

"Ligand discrimination in signaling through an ErbB4 receptor homodimer."
Sweeney C. , Lai C. , Riese D.J. II , Diamonti A.J. , Cantley L.C. , Carraway K.L. III
J. Biol. Chem.275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB4
19.

"Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4."
Nagata K. , Kohda D. , Hatanaka H. , Ichikawa S. , Matsuda S. , Yamamoto T. , Suzuki A. , Inagaki F.
EMBO J.13:3517-3523(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 175-241 (ISOFORM 1)
20.

"High-resolution solution structure of the EGF-like domain of heregulin-alpha."
Jacobsen N.E. , Abadi N. , Sliwkowski M.X. , Reilly D. , Skelton N.J. , Fairbrother W.J.
Biochemistry35:3402-3417(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 177-239 (ISOFORM 1);DISULFIDE BONDS

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