Nrg1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comNrg1 ELISA Kit for Rat(Rattus norvegicus)

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Nrg1 (Gene name),

Pro-neuregulin-1, membrane-bound isoform (Protein name ), NRG1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

Nrg1(Ndf);

Protein name:

Pro-neuregulin-1, membrane-bound isoform(Pro-NRG1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

The cytoplasmic domain interacts with the LIM domain region of LIMK1.

Function:

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vessicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart.

Subcellular Location:

Neuregulin-1 Secreted

Protein Attributes:

Sequence length:

662

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

662:

SSVIANQDPI | AV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P43322

UniGene:

Rn.37438

Pfam:

PF07679

KEGG:

rno:112400

String:

P43322

Uniprot:

P43322

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ELISA Kit for Rat Pro-NRG1

Cat.:

E1866h

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96T

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ELISA Kit for Rat Pro-NRG1

Cat.:

E1866r

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96T

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ELISA Kit for Rat Pro-NRG1

Cat.:

E1866c

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96T

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CLIA Kit for Rat Pro-NRG1

Cat.:

U1866r

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96T

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CLIA Kit for Rat Pro-NRG1

Cat.:

U1866h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Rat Pro-NRG1

Cat.:

U1866c

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Pro-NRG1

Cat.:

P1866Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Pro-NRG1

Cat.:

P1866Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Pro-NRG1

Protein for Rat Pro-NRG1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Therapeutic effect of co-transplantation of neuregulin 1-transfected-Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome"

Ji Fei Zhang , Fu Sheng Zhao, Geng Wu, Qing Fei Kong, Bo Sun, Jingyan Cao, Yao Zhang, Jing Hua Wang, Jing Zhang, Xu Dong Jin , Hu Lun Li

From:Neuroscience Letters

References

1.

"Structural and functional aspects of the multiplicity of Neu differentiation factors."
Wen D. , Suggs S.V. , Karunagaran D. , Liu N. , Cupples R.L. , Luo Y. , Janssen A.M. , Ben-Baruch N. , Trollinger D.B. , Jacobsen V.L. , Meng S.-Y. , Lu H.S. , Hu S. , Chang D. , Yang W. , Yanigahara D. , Koski R.A. , Yarden Y.
Mol. Cell. Biol.14:1909-1919(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue: Fibroblast.
2.

"Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit."
Wen D. , Peles E. , Cupples R. , Suggs S.V. , Bacus S.S. , Luo Y. , Trail G. , Hu S. , Silbiger S.M. , Levy R.B. , Koski R.A. , Lu H.S. , Yarden Y.
Cell69:559-572(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA2C);PARTIAL PROTEIN SEQUENCE
tissue: Fibroblast.
3.

"Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells."
Peles E. , Bacus S.S. , Koski R.A. , Lu H.S. , Wen D. , Ogden S.G. , Levy R.B. , Yarden Y.
Cell69:205-216(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 14-36
4.

"Release of the neuregulin functional polypeptide requires its cytoplasmic tail."
Liu X. , Hwang H. , Cao L. , Wen D. , Liu N. , Graham R.M. , Zhou M.
J. Biol. Chem.273:34335-34340(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGULATION OF PROCESSING (ISOFORM ALPHA2C)
5.

"Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition."
Wang J.Y. , Frenzel K.E. , Wen D. , Falls D.L.
J. Biol. Chem.273:20525-20534(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIMK1
6.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons."
Liu Y. , Tao Y.M. , Woo R.S. , Xiong W.C. , Mei L.
Biochem. Biophys. Res. Commun.354:505-510(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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