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Index > Protein center > NRP1(Gene name) > Human
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  • NRP1 (Gene name),
  • Neuropilin-1 (Protein name ),  NRP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    NRP1(NRP;VEGF165R);
    Protein name:
    Neuropilin-1;
    Alternative:
    Vascular endothelial cell growth factor 165 receptor;
    CD:
    CD304;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with NRP2. Binds PLXNB1.
    Function:
    The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    923
    Sequence:
    50:
    MERGLPLLCA | VLALVLAPAG | AFRNDKCGDT | IKIESPGYLT | SPGYPHSYHP | 
    100:
    SEKCEWLIQA | PDPYQRIMIN | FNPHFDLEDR | DCKYDYVEVF | DGENENGHFR | 
    150:
    GKFCGKIAPP | PVVSSGPFLF | IKFVSDYETH | GAGFSIRYEI | FKRGPECSQN | 
    200:
    YTTPSGVIKS | PGFPEKYPNS | LECTYIVFVP | KMSEIILEFE | SFDLEPDSNP | 
    250:
    PGGMFCRYDR | LEIWDGFPDV | GPHIGRYCGQ | KTPGRIRSSS | GILSMVFYTD | 
    300:
    SAIAKEGFSA | NYSVLQSSVS | EDFKCMEALG | MESGEIHSDQ | ITASSQYSTN | 
    350:
    WSAERSRLNY | PENGWTPGED | SYREWIQVDL | GLLRFVTAVG | TQGAISKETK | 
    400:
    KKYYVKTYKI | DVSSNGEDWI | TIKEGNKPVL | FQGNTNPTDV | VVAVFPKPLI | 
    450:
    TRFVRIKPAT | WETGISMRFE | VYGCKITDYP | CSGMLGMVSG | LISDSQITSS | 
    500:
    NQGDRNWMPE | NIRLVTSRSG | WALPPAPHSY | INEWLQIDLG | EEKIVRGIII | 
    550:
    QGGKHRENKV | FMRKFKIGYS | NNGSDWKMIM | DDSKRKAKSF | EGNNNYDTPE | 
    600:
    LRTFPALSTR | FIRIYPERAT | HGGLGLRMEL | LGCEVEAPTA | GPTTPNGNLV | 
    650:
    DECDDDQANC | HSGTGDDFQL | TGGTTVLATE | KPTVIDSTIQ | SEFPTYGFNC | 
    700:
    EFGWGSHKTF | CHWEHDNHVQ | LKWSVLTSKT | GPIQDHTGDG | NFIYSQADEN | 
    750:
    QKGKVARLVS | PVVYSQNSAH | CMTFWYHMSG | SHVGTLRVKL | RYQKPEEYDQ | 
    800:
    LVWMAIGHQG | DHWKEGRVLL | HKSLKLYQVI | FEGEIGKGNL | GGIAVDDISI | 
    850:
    NNHISQEDCA | KPADLDKKNP | EIKIDETGST | PGYEGEGEGD | KNISRKPGNV | 
    900:
    LKTLDPILIT | IIAMSALGVL | LGAVCGVVLY | CACWHNGMSE | RNLSALENYN | 
    923:
    FELVDGVKLK | KDKLNTQSTY | SEA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    String:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Neuropilin-1
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    ELISA Kit for Human Neuropilin-1
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    E1843m
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    ELISA Kit for Human Neuropilin-1
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    E1843r
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    ELISA Kit for Human Neuropilin-1
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    E1843c
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    96T
    CLIA Kit for Human Neuropilin-1
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    U1843r
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    96T
    CLIA Kit for Human Neuropilin-1
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    U1843c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Neuropilin-1
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    U1843m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Neuropilin-1
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    U1843h
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    Polyclonal Antibody for Human Neuropilin-1
    Cat.:
    P1843Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Neuropilin-1
    Cat.:
    P1843Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Neuropilin-1
    Polyclonal Antibody for Human Neuropilin-1
    Cat.:
    P1843Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Neuropilin-1
    Monoclonal Antibody for Human Neuropilin-1
    Monoclonal Antibody for Human Neuropilin-1
    Monoclonal Antibody for Human Neuropilin-1
    Protein for Human Neuropilin-1
    Protein for Human Neuropilin-1
    Protein for Human Neuropilin-1
    Protein for Human Neuropilin-1

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    References
    1. 1.
      "Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
      He Z. , Tessier-Lavigne M.
      Cell90:739-751(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-179
    2. 2.
      "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
      Soker S. , Takashima S. , Miao H.-Q. , Neufeld G. , Klagsbrun M.
      Cell92:735-745(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 22-39;VARIANT ALA-179
      tissue: Mammary gland.
    3. 3.
      "Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity."
      Gagnon M.L. , Bielenberg D.R. , Gechtman Z. , Miao H.-Q. , Takashima S. , Soker S. , Klagsbrun M.
      Proc. Natl. Acad. Sci. U.S.A.97:2573-2578(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 22-31;VARIANT ALA-179
      tissue: Prostatic adenocarcinoma.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-179
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-179
      tissue: Skeletal muscle.
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-179
    7. 7.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-179
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANT ALA-179
      tissue: Kidney.
      tissue: Muscle.
    10. 10.
      "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
      Tamagnone L. , Artigiani S. , Chen H. , He Z. , Ming G.-L. , Song H.-L. , Chedotal A. , Winberg M.L. , Goodman C.S. , Poo M.-M. , Tessier-Lavigne M. , Comoglio P.M.
      Cell99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLXNB1
    11. 11.
      "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
      Gluzman-Poltorak Z. , Cohen T. , Herzog Y. , Neufeld G.
      J. Biol. Chem.275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    12. 12.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150
      tissue: Plasma.
    13. 13.
      "Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling."
      Shintani Y. , Takashima S. , Asano Y. , Kato H. , Liao Y. , Yamazaki S. , Tsukamoto O. , Seguchi O. , Yamamoto H. , Fukushima T. , Sugahara K. , Kitakaze M. , Hori M.
      EMBO J.25:3045-3055(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-612
    14. 14.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150; ASN-261 AND ASN-522
      tissue: Liver.
    15. 15.
      "Crystal structure of the human neuropilin-1 b1 domain."
      Lee C.C. , Kreusch A. , McMullan D. , Ng K. , Spraggon G.
      Structure11:99-108(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 273-427
    16. 16.
      "Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding."
      Appleton B.A. , Wu P. , Maloney J. , Yin J. , Liang W.C. , Stawicki S. , Mortara K. , Bowman K.K. , Elliott J.M. , Desmarais W. , Bazan J.F. , Bagri A. , Tessier-Lavigne M. , Koch A.W. , Wu Y. , Watts R.J. , Wiesmann C.
      EMBO J.26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 141-586 ALONE AND IN COMPLEX WITH ANTIBODY;GLYCOSYLATION AT ASN-150 AND ASN-261;SUBUNIT;CALCIUM-BINDING SITES;HEPARIN-BINDING;DISULFIDE BONDS
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