NRP1 ELISA Kit for Human(Homo sapiens) | EIAab.comNRP1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NRP1(Gene name) > Human

NRP1 (Gene name),

Neuropilin-1 (Protein name ), NRP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

NRP1(NRP;VEGF165R);

Protein name:

Neuropilin-1;

Alternative:

Vascular endothelial cell growth factor 165 receptor;

CD:

CD304;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer, and heterodimer with NRP2. Binds PLXNB1.

Function:

The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subcellular Location:

Isoform 2 Secreted

Protein Attributes:

Sequence length:

923

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

923:

FELVDGVKLK | KDKLNTQSTY | SEA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000265371

SMR:

O14786

KEGG:

hsa:8829

String:

O14786

Pfam:

PF00431

UniGene:

Hs.131704

MIM:

602069

Uniprot:

O14786

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ELISA Kit for Human Neuropilin-1

Cat.:

E1843h

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Packing:

96T

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ELISA Kit for Human Neuropilin-1

Cat.:

E1843m

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96T

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ELISA Kit for Human Neuropilin-1

Cat.:

E1843r

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MSDS:

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Packing:

96T

ELISA Kit for Human Neuropilin-1

Cat.:

E1843c

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Packing:

96T

CLIA Kit for Human Neuropilin-1

Cat.:

U1843r

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Packing:

96T

CLIA Kit for Human Neuropilin-1

Cat.:

U1843c

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Packing:

96T

CLIA Kit for Human Neuropilin-1

Cat.:

U1843m

Price:

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Neuropilin-1

Cat.:

U1843h

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Manual:

Looking for manual.

MSDS:

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96T

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Polyclonal Antibody for Human Neuropilin-1

Cat.:

P1843Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Neuropilin-1

Cat.:

P1843Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Neuropilin-1

Cat.:

P1843Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Neuropilin-1

Protein for Human Neuropilin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Plasma vascular endothelial growth factor 165 in advanced nonsmall cell lung cancer"

E Bastawisy

From:Oncology Letters

References

1.

"Neuropilin is a receptor for the axonal chemorepellent semaphorin III."
He Z. , Tessier-Lavigne M.
Cell90:739-751(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-179
2.

"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
Soker S. , Takashima S. , Miao H.-Q. , Neufeld G. , Klagsbrun M.
Cell92:735-745(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 22-39;VARIANT ALA-179
tissue: Mammary gland.
3.

"Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: in vivo expression and antitumor activity."
Gagnon M.L. , Bielenberg D.R. , Gechtman Z. , Miao H.-Q. , Takashima S. , Soker S. , Klagsbrun M.
Proc. Natl. Acad. Sci. U.S.A.97:2573-2578(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF 22-31;VARIANT ALA-179
tissue: Prostatic adenocarcinoma.
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-179
5.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-179
tissue: Skeletal muscle.
6.

SeattleSNPs variation discovery resource
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-179
7.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-179
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANT ALA-179
tissue: Kidney.
tissue: Muscle.
10.

"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
Tamagnone L. , Artigiani S. , Chen H. , He Z. , Ming G.-L. , Song H.-L. , Chedotal A. , Winberg M.L. , Goodman C.S. , Poo M.-M. , Tessier-Lavigne M. , Comoglio P.M.
Cell99:71-80(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLXNB1
11.

"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
Gluzman-Poltorak Z. , Cohen T. , Herzog Y. , Neufeld G.
J. Biol. Chem.275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
12.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150
tissue: Plasma.
13.

"Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling."
Shintani Y. , Takashima S. , Asano Y. , Kato H. , Liao Y. , Yamazaki S. , Tsukamoto O. , Seguchi O. , Yamamoto H. , Fukushima T. , Sugahara K. , Kitakaze M. , Hori M.
EMBO J.25:3045-3055(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-612
14.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-150; ASN-261 AND ASN-522
tissue: Liver.
15.

"Crystal structure of the human neuropilin-1 b1 domain."
Lee C.C. , Kreusch A. , McMullan D. , Ng K. , Spraggon G.
Structure11:99-108(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 273-427
16.

"Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding."
Appleton B.A. , Wu P. , Maloney J. , Yin J. , Liang W.C. , Stawicki S. , Mortara K. , Bowman K.K. , Elliott J.M. , Desmarais W. , Bazan J.F. , Bagri A. , Tessier-Lavigne M. , Koch A.W. , Wu Y. , Watts R.J. , Wiesmann C.
EMBO J.26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 141-586 ALONE AND IN COMPLEX WITH ANTIBODY;GLYCOSYLATION AT ASN-150 AND ASN-261;SUBUNIT;CALCIUM-BINDING SITES;HEPARIN-BINDING;DISULFIDE BONDS

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