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Index > Protein center > NUSAP1(Gene name) > Human
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  • NUSAP1 (Gene name),
  • Nucleolar and spindle-associated protein 1 (Protein name ),  NUSAP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NUSAP1(BM-037;PRO0310;ANKT);
    Protein name:
    Nucleolar and spindle-associated protein 1(NuSAP);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2.
    Function:
    Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.
    Subcellular Location:
    Cytoplasm Nucleus nucleolus Cytoplasm cytoskeleton spindle Chromosome Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis.
    Protein Attributes:
    Sequence length:
    441
    Sequence:
    50:
    MIIPSLEELD | SLKYSDLQNL | AKSLGLRANL | RATKLLKALK | GYIKHEARKG | 
    100:
    NENQDESQTS | ASSCDETEIQ | ISNQEEAERQ | PLGHVTKTRR | RCKTVRVDPD | 
    150:
    SQQNHSEIKI | SNPTEFQNHE | KQESQDLRAT | AKVPSPPDEH | QEAENAVSSG | 
    200:
    NRDSKVPSEG | KKSLYTDESS | KPGKNKRTAI | TTPNFKKLHE | AHFKEMESID | 
    250:
    QYIERKKKHF | EEHNSMNELK | QQPINKGGVR | TPVPPRGRLS | VASTPISQRR | 
    300:
    SQGRSCGPAS | QSTLGLKGSL | KRSAISAAKT | GVRFSAATKD | NEHKRSLTKT | 
    350:
    PARKSAHVTV | SGGTPKGEAV | LGTHKLKTIT | GNSAAVITPF | KLTTEATQTP | 
    400:
    VSNKKPVFDL | KASLSRPLNY | EPHKGKLKPW | GQSKENNYLN | QHVNRINFYK | 
    441:
    KTYKQPHLQT | KEEQRKKREQ | ERKEKKAKVL | GMRRGLILAE | D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human NuSAP
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    E0523h
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    96T
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    ELISA Kit for Human NuSAP
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    E0523b
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    Packing:
    96T
    ELISA Kit for Human NuSAP
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    E0523c
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    ELISA Kit for Human NuSAP
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    E0523m
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    CLIA Kit for Human NuSAP
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    U0523m
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    Packing:
    96T
    CLIA Kit for Human NuSAP
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    U0523h
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    MSDS:
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    96T
    CLIA Kit for Human NuSAP
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    U0523c
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    MSDS:
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    96T
    CLIA Kit for Human NuSAP
    Cat.:
    U0523b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NuSAP
    Polyclonal Antibody for Human NuSAP
    Cat.:
    P0523Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NuSAP
    Cat.:
    P0523Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NuSAP
    Monoclonal Antibody for Human NuSAP
    Monoclonal Antibody for Human NuSAP
    Monoclonal Antibody for Human NuSAP
    Monoclonal Antibody for Human NuSAP
    Protein for Human NuSAP
    Protein for Human NuSAP
    Protein for Human NuSAP
    Protein for Human NuSAP

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    References
    1. 1.
      "Homo sapiens liver nuclear protein mRNA."
      Qu X. , Zhang C. , Yu Y. , Wu S. , Wei H. , Xing G. , Zhai Y. , Lu C. , Wang M. , He F.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal liver.
    2. 2.
      "A novel nucleolar protein expressed in proliferating cells."
      Sato H. , Tanaka Y. , Taniguchi M.
      Submitted (2000-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Peripheral blood.
    3. 3.
      "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
      Yu Y. , Zhang C. , Zhou G. , Wu S. , Qu X. , Wei H. , Xing G. , Dong C. , Zhai Y. , Wan J. , Ouyang S. , Li L. , Zhang S. , Zhou K. , Zhang Y. , Wu C. , He F.
      Genome Res.11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Fetal liver.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 7)
      tissue: Neuroblastoma.
      tissue: Placenta.
    5. 5.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Liver.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-441 (ISOFORM 4)
      tissue: Cervix.
      tissue: Lung.
      tissue: Lymph.
      tissue: Placenta.
    9. 10.
      "A novel gene expressed in human bone marrow."
      Zhao M. , Gu J. , Li N. , Peng Y. , Han Z. , Chen Z.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-207 (ISOFORMS 1/2)
      tissue: Bone marrow.
    10. 11.
      "NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization."
      Raemaekers T. , Ribbeck K. , Beaudouin J. , Annaert W. , Van Camp M. , Stockmans I. , Smets N. , Bouillon R. , Ellenberg J. , Carmeliet G.
      J. Cell Biol.162:1017-1029(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 12.
      "NuSAP is degraded by APC/C-Cdh1 and its overexpression results in mitotic arrest dependent of its microtubules' affinity."
      Li L. , Zhou Y. , Sun L. , Xing G. , Tian C. , Sun J. , Zhang L. , He F.
      Cell. Signal.19:2046-2055(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;UBIQUITINATION
    12. 13.
      "A role for NuSAP in linking microtubules to mitotic chromosomes."
      Ribbeck K. , Raemaekers T. , Carmeliet G. , Mattaj I.W.
      Curr. Biol.17:230-236(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ASSOCIATION WITH CHROMATIN
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; THR-182; SER-240; THR-244; SER-247; THR-314 AND SER-352;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-338;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 17.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-411;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-135; SER-240; SER-276; SER-311; THR-314 AND SER-352;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 20.
      "ATM-mediated NuSAP phosphorylation induces mitotic arrest."
      Xie P. , Li L. , Xing G. , Tian C. , Yin Y. , He F. , Zhang L.
      Biochem. Biophys. Res. Commun.404:413-418(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-124 BY ATM
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