Gene name:
O3FAR1 (GPR120;GPR129;PGR4) ;
Protein name:
Omega-3 fatty acid receptor 1 ;
Alternative:
G-protein coupled receptor 129 ;G-protein coupled receptor 120 ;G-protein coupled receptor PGR4 ;G-protein coupled receptor GT01 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with ARRB2 following docosahexaenoic acid (DHA) stimulation.
Function:
Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particulary in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Colocalized with ARRB2 following DHA treatment.
Protein Attributes:
50:
MSPECARAAG | DAPLRSLEQA | NRTRFPFFSD | VKGDHRLVLA | AVETTVLVLI |
100:
FAVSLLGNVC | ALVLVARRRR | RGATACLVLN | LFCADLLFIS | AIPLVLAVRW |
150:
TEAWLLGPVA | CHLLFYVMTL | SGSVTILTLA | AVSLERMVCI | VHLQRGVRGP |
200:
GRRARAVLLA | LIWGYSAVAA | LPLCVFFRVV | PQRLPGADQE | ISICTLIWPT |
250:
IPGEISWDVS | FVTLNFLVPG | LVIVISYSKI | LQTSEHLLDA | RAVVTHSEIT |
300:
KASRKRLTVS | LAYSESHQIR | VSQQDFRLFR | TLFLLMVSFF | IMWSPIIITI |
350:
LLILIQNFKQ | DLVIWPSLFF | WVVAFTFANS | ALNPILYNMT | LCRNEWKKIF |
377:
CCFWFPEKGA | ILTDTSVKRN | DLSIISG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Omega-3 fatty acid receptor 1
ELISA Kit for Human Omega-3 fatty acid receptor 1
ELISA Kit for Human Omega-3 fatty acid receptor 1
CLIA Kit for Human Omega-3 fatty acid receptor 1
CLIA Kit for Human Omega-3 fatty acid receptor 1
CLIA Kit for Human Omega-3 fatty acid receptor 1
Polyclonal Antibody for Human Omega-3 fatty acid receptor 1
Polyclonal Antibody for Human Omega-3 fatty acid receptor 1
Polyclonal Antibody for Human Omega-3 fatty acid receptor 1
Monoclonal Antibody for Human Omega-3 fatty acid receptor 1
Monoclonal Antibody for Human Omega-3 fatty acid receptor 1
Monoclonal Antibody for Human Omega-3 fatty acid receptor 1
Protein for Human Omega-3 fatty acid receptor 1
Protein for Human Omega-3 fatty acid receptor 1
Protein for Human Omega-3 fatty acid receptor 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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