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Index > Protein center > OSM(Gene name) > Human
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  • OSM (Gene name),
  • Oncostatin-M (Protein name ),  ONCM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    OSM;
    Protein name:
    Oncostatin-M(OSM);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    252
    Sequence:
    50:
    MGVLLTQRTL | LSLVLALLFP | SMASMAAIGS | CSKEYRVLLG | QLQKQTDLMQ | 
    100:
    DTSRLLDPYI | RIQGLDVPKL | REHCRERPGA | FPSEETLRGL | GRRGFLQTLN | 
    150:
    ATLGCVLHRL | ADLEQRLPKA | QDLERSGLNI | EDLEKLQMAR | PNILGLRNNI | 
    200:
    YCMAQLLDNS | DTAEPTKAGR | GASQPPTPTP | ASDAFQRKLE | GCRFLHGYHR | 
    250:
    FMHSVGRVFS | KWGESPNRSR | RHSPHQALRK | GVRRTRPSRK | GKRLMTRGQL | 
    252:
    PR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human OSM
    Cat.:
    E0110m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human OSM
    Cat.:
    E0110h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human OSM
    Cat.:
    E0110r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human OSM
    Cat.:
    E0110b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human OSM
    Cat.:
    U0110h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human OSM
    Cat.:
    U0110m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human OSM
    Cat.:
    U0110r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human OSM
    Cat.:
    U0110b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human OSM
    Cat.:
    P0110Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human OSM
    Cat.:
    P0110Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human OSM
    Cat.:
    P0110Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human OSM
    Monoclonal Antibody for Human OSM
    Monoclonal Antibody for Human OSM
    Monoclonal Antibody for Human OSM
    Monoclonal Antibody for Human OSM
    Protein for Human OSM
    Protein for Human OSM
    Protein for Human OSM
    Protein for Human OSM

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    Linearity
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    References
    1. 1.
      "Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M."
      Malik N. , Kallestad J.C. , Gunderson N.L. , Austin S.D. , Neubauer M.G. , Ochs V. , Marquardt H. , Zarling J.M. , Shoyab M. , Wei C.M. , Linsley P.S. , Rose T.M.
      Mol. Cell. Biol.9:2847-2853(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    7. 7.
      "Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells."
      Zarling J.M. , Shoyab M. , Marquardt H. , Hanson M.B. , Lioubin M.N. , Todaro G.J.
      Proc. Natl. Acad. Sci. U.S.A.83:9739-9743(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-51
    8. 8.
      "Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M."
      Nair B.C. , DeVico A.L. , Nakamura S. , Copeland T.D. , Chen Y. , Patel A. , O'Neil T. , Oroszlan S. , Gallo R.C. , Sarngadharan M.G.
      Science255:1430-1432(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-45;FUNCTION
      tissue: T-cell.
    9. 9.
      "Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M."
      Linsley P.S. , Kallestad J. , Ochs V. , Neubauer M.
      Mol. Cell. Biol.10:1882-1890(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;MUTAGENESIS OF ARG-220 AND ARG-221
    10. 10.
      "Disulfide bond assignment and identification of regions required for functional activity of oncostatin M."
      Kallestad J.C. , Shoyab M. , Linsley P.S.
      J. Biol. Chem.266:8940-8945(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    11. 11.
      "Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6."
      Rose T.M. , Bruce A.G.
      Proc. Natl. Acad. Sci. U.S.A.88:8641-8645(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION OF M1 MYELOID LEUKEMIC CELLS
    12. 12.
      "Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells."
      Miles S.A. , Martinez-Maza O. , Rezai A. , Magpantay L. , Kishimoto T. , Nakamura S. , Radka S.F. , Linsley P.S.
      Science255:1432-1434(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
      Mosley B. , De Imus C. , Friend D. , Boiani N. , Thoma B. , Park L.S. , Cosman D.
      J. Biol. Chem.271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH OSMR AND IL6ST
    14. 14.
      "Crystal structure and functional dissection of the cytostatic cytokine oncostatin M."
      Deller M.C. , Hudson K.R. , Ikemizu S. , Bravo J. , Jones E.Y. , Heath J.K.
      Structure8:863-874(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 26-212
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