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Index > Protein center > OPLAH(Gene name) > Human
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  • OPLAH (Gene name),
  • 5-oxoprolinase (Protein name ),  OPLA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    OPLAH;
    Protein name:
    5-oxoprolinase;
    Alternative:
    Pyroglutamase;5-oxo-L-prolinase(5-OPase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1288
    Sequence:
    50:
    MGSPEGRFHF | AIDRGGTFTD | VFAQCPGGHV | RVLKLLSEDP | ANYADAPTEG | 
    100:
    IRRILEQEAG | MLLPRDQPLD | SSHIASIRMG | TTVATNALLE | RKGERVALLV | 
    150:
    TRGFRDLLHI | GTQARGDLFD | LAVPMPEVLY | EEVLEVDERV | VLHRGEAGTG | 
    200:
    TPVKGRTGDL | LEVQQPVDLG | ALRGKLEGLL | SRGIRSLAVV | LMHSYTWAQH | 
    250:
    EQQVGVLARE | LGFTHVSLSS | EAMPMVRIVP | RGHTACADAY | LTPAIQRYVQ | 
    300:
    GFCRGFQGQL | KDVQVLFMRS | DGGLAPMDTF | SGSSAVLSGP | AGGVVGYSAT | 
    350:
    TYQQEGGQPV | IGFDMGGTST | DVSRYAGEFE | HVFEASTAGV | TLQAPQLDIN | 
    400:
    TVAAGGGSRL | FFRSGLFVVG | PESAGAHPGP | ACYRKGGPVT | VTDANLVLGR | 
    450:
    LLPASFPCIF | GPGENQPLSP | EASRKALEAV | ATEVNSFLTN | GPCPASPLSL | 
    500:
    EEVAMGFVRV | ANEAMCRPIR | ALTQARGHDP | SAHVLACFGG | AGGQHACAIA | 
    550:
    RALGMDTVHI | HRHSGLLSAL | GLALADVVHE | AQEPCSLLYA | PETFVQLDQR | 
    600:
    LSRLEEQCVD | ALQAQGFPRS | QISTESFLHL | RYQGTDCALM | VSAHQHPATA | 
    650:
    RSPRAGDFGA | AFVERYMREF | GFVIPERPVV | VDDVRVRGTG | RSGLRLEDAP | 
    700:
    KAQTGPPRVD | KMTQCYFEGG | YQETPVYLLA | ELGYGHKLHG | PCLIIDSNST | 
    750:
    ILVEPGCQAE | VTKTGDICIS | VGAEVPGTVG | PQLDPIQLSI | FSHRFMSIAE | 
    800:
    QMGRILQRTA | ISTNIKERLD | FSCALFGPDG | GLVSNAPHIP | VHLGAMQETV | 
    850:
    QFQIQHLGAD | LHPGDVLLSN | HPSAGGSHLP | DLTVITPVFW | PGQTRPVFYV | 
    900:
    ASRGHHADIG | GITPGSMPPH | STMLQQEGAV | FLSFKLVQGG | VFQEEAVTEA | 
    950:
    LRAPGKVPNC | SGTRNLHDNL | SDLRAQVAAN | QKGIQLVGEL | IGQYGLDVVQ | 
    1000:
    AYMGHIQANA | ELAVRDMLRA | FGTSRQARGL | PLEVSSEDHM | DDGSPIRLRV | 
    1050:
    QISLSQGSAV | FDFSGTGPEV | FGNLNAPRAV | TLSALIYCLR | CLVGRDIPLN | 
    1100:
    QGCLAPVRVV | IPRGSILDPS | PEAAVVGGNV | LTSQRVVDVI | LGAFGACAAS | 
    1150:
    QGCMNNVTLG | NAHMGYYETV | AGGAGAGPSW | HGRSGVHSHM | TNTRITDPEI | 
    1200:
    LESRYPVILR | RFELRRGSGG | RGRFRGGDGV | TRELLFREEA | LLSVLTERRA | 
    1250:
    FRPYGLHGGE | PGARGLNLLI | RKNGRTVNLG | GKTSVTVYPG | DVFCLHTPGG | 
    1288:
    GGYGDPEDPA | PPPGSPPQAL | AFPEHGSVYE | YRRAQEAV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human 5-oxoprolinase
    Cat.:
    E6081m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human 5-oxoprolinase
    Cat.:
    E6081r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human 5-oxoprolinase
    Cat.:
    E6081h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human 5-oxoprolinase
    Cat.:
    E6081b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 5-oxoprolinase
    Cat.:
    U6081m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 5-oxoprolinase
    Cat.:
    U6081r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 5-oxoprolinase
    Cat.:
    U6081h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 5-oxoprolinase
    Cat.:
    U6081b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human 5-oxoprolinase
    Cat.:
    P6081Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 5-oxoprolinase
    Polyclonal Antibody for Human 5-oxoprolinase
    Polyclonal Antibody for Human 5-oxoprolinase
    Cat.:
    P6081Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 5-oxoprolinase
    Monoclonal Antibody for Human 5-oxoprolinase
    Monoclonal Antibody for Human 5-oxoprolinase
    Monoclonal Antibody for Human 5-oxoprolinase
    Protein for Human 5-oxoprolinase
    Protein for Human 5-oxoprolinase
    Protein for Human 5-oxoprolinase
    Protein for Human 5-oxoprolinase

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    s

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤5.7%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.6%

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Recovery was determined by spiking various levels of OPLA into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    94

    91-100

    Plasma

    96

    93-103

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of OPLA and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    90-100%

    88-101%

    91-97%

    92-98%

    EDTA plasma(n=5)

    89-105%

    90-102%

    88-103%

    90-104%

    heparin plasma(n=5)

    93-101%

     

    94-99%

    92-100%

    91-101%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA cloning, and detection of mRNA in the coronary artery."
      Watanabe T. , Abe K. , Ishikawa H. , Iijima Y.
      Biol. Pharm. Bull.27:288-294(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 229-1288
      tissue: Testis.
    4. 4.
      "Human 5-oxo-L-prolinase partial sequence."
      Debella L.R. , Wood S.
      Submitted (1997-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 901-1096
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "5-Oxoprolinase deficiency: report of the first human OPLAH mutation."
      Almaghlouth I. , Mohamed J. , Al-Amoudi M. , Al-Ahaidib L. , Al-Odaib A. , Alkuraya F.
      Clin. Genet.82:193-196(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN OPLAHD
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