Oprm1 ELISA Kit for Mouse(Mus musculus) | EIAab.comOprm1 ELISA Kit for Mouse(Mus musculus)

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Oprm1 (Gene name),

Mu-type opioid receptor (Protein name ), OPRM_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Oprm1(Mor;Oprm);

Protein name:

Mu-type opioid receptor(M-OR-1;MOR-1);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20.

Function:

Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

398

Sequence:

50:

100:

150:

200:

250:

300:

350:

398:

CIPTSSTIEQ | QNSARIRQNT | REHPSTANTV | DRTNHQLENL | EAETAPLP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P42866

UniGene:

Mm.457998

KEGG:

mmu:18390

STRING:

10090.ENSMUSP00000101239

Pfam:

PF00001

UniGene:

Mm.439715

SMR:

P42866

Uniprot:

P42866

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ELISA Kit for Mouse M-OR-1

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E0714h

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ELISA Kit for Mouse M-OR-1

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E0714r

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ELISA Kit for Mouse M-OR-1

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E0714p

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ELISA Kit for Mouse M-OR-1

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E0714m

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ELISA Kit for Mouse M-OR-1

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E0714b

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CLIA Kit for Mouse M-OR-1

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U0714r

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96T

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CLIA Kit for Mouse M-OR-1

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U0714h

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CLIA Kit for Mouse M-OR-1

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U0714m

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96T

CLIA Kit for Mouse M-OR-1

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U0714p

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96T

CLIA Kit for Mouse M-OR-1

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U0714b

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Polyclonal Antibody for Mouse M-OR-1

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P0714Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse M-OR-1

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P0714Rb-h

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Polyclonal Antibody for Mouse M-OR-1

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P0714Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse M-OR-1

Protein for Mouse M-OR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Genomic structure analysis of promoter sequence of a mouse mu opioid receptor gene."
Min B.H. , Augustin L.B. , Felsheim R.F. , Fuchs J.A. , Loh H.H.
Proc. Natl. Acad. Sci. U.S.A.91:9081-9085(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: C57BL/6.
tissue: Liver.
2.

"Antisense mapping the MOR-1 opioid receptor: evidence for alternative splicing and a novel morphine-6 beta-glucuronide receptor."
Rossi G.C. , Pan Y.X. , Brown G.P. , Pasternak G.W.
FEBS Lett.369:192-196(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Characterization of the murine mu opioid receptor gene."
Kaufman D.L. , Keith D.E. , Anton B. , Tian J. , Magendzo K. , Newman D. , Tran T. , Lee D.S. , Wen C. , Xia Y. , Lusis A.J. , Evans C.J.
J. Biol. Chem.270:15877-15883(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
strain: BALB/c.
tissue: Brain.
4.

"Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms."
Pan Y.X. , Xu J. , Bolan E. , Abbadie C. , Chang A. , Zuckerman A. , Rossi G. , Pasternak G.W.
Mol. Pharmacol.56:396-403(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8; 9 AND 10)
strain: C57BL/6.
5.

"Identification and characterization of a mouse spliced mu-opioid receptor isoform (MOR-1A)."
Pan Y.-X. , Xu J. , Chang A. , Pasternak G.W.
Submitted (1999-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: CD-1.
6.

"Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F."
Pan Y.X. , Xu J. , Bolan E. , Chang A. , Mahurter L. , Rossi G. , Pasternak G.W.
FEBS Lett.466:337-340(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11)
strain: CD-1.
7.

"The untranslated region of (mu)-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice."
Ikeda K. , Kobayashi T. , Ichikawa T. , Kumanishi T. , Niki H. , Yano R.
J. Neurosci.21:1334-1339(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6By x BALB/cBy.
tissue: Brain.
8.

"Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene."
Pan Y.X. , Xu J. , Mahurter L. , Bolan E. , Xu M. , Pasternak G.W.
Proc. Natl. Acad. Sci. U.S.A.98:14084-14089(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 14; 15 AND 16)
strain: C57BL/6By x BALB/cBy.
9.

"Identification and characterization of a novel splice variant from mouse mu opioid receptor gene (Oprm)."
Pan Y. , Xu J. , Xu M. , Pasternak G.W.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 13)
10.

"Identification and characterization of a new isoform from mouse mu opioid receptor gene Oprm."
Xu J. , Pasternak G.W.
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12)
strain: CD-1.
11.

"Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing."
Pan Y.X. , Xu J. , Bolan E. , Moskowitz H.S. , Xu M. , Pasternak G.W.
Mol. Pharmacol.68:866-875(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5; 6 AND 7)
strain: CD-1.
12.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8)
13.

"Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon."
Doyle G.A. , Sheng X.R. , Lin S.S. , Press D.M. , Grice D.E. , Buono R.J. , Ferraro T.N. , Berrettini W.H.
Gene395:98-107(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 10; 17; 18 AND 19)
strain: C57BL/6.
tissue: Brain.
14.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
16.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8)
17.

"Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia."
Sora I. , Takahashi N. , Funada M. , Ujike H. , Revay R.S. , Donovan D.M. , Miner L.L. , Uhl G.R.
Proc. Natl. Acad. Sci. U.S.A.94:1544-1549(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors."
Garzon J. , Castro M. , Sanchez-Blazquez P.
Eur. J. Neurosci.10:2557-2564(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COUPLING TO GNAZ
19.

"Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties."
George S.R. , Fan T. , Xie Z. , Tse R. , Tam V. , Varghese G. , O'Dowd B.F.
J. Biol. Chem.275:26128-26135(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;FUNCTION;INTERACTION WITH OPRD1
20.

"Dimerization of morphine and orphanin FQ/nociceptin receptors: generation of a novel opioid receptor subtype."
Pan Y.X. , Bolan E. , Pasternak G.W.
Biochem. Biophys. Res. Commun.297:659-663(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH OPRL1
21.

"Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors."
Borgland S.L. , Connor M. , Osborne P.B. , Furness J.B. , Christie M.J.
J. Biol. Chem.278:18776-18784(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR DESENSITIZATION;SUBCELLULAR LOCATION;RECEPTOR INTERNALIZATION
22.

"A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors."
Tanowitz M. , von Zastrow M.
J. Biol. Chem.278:45978-45986(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR RECYCLING;MUTAGENESIS OF LEU-387 AND LEU-390
23.

"Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing."
Kvam T.M. , Baar C. , Rakvag T.T. , Kaasa S. , Krokan H.E. , Skorpen F.
J. Mol. Med.82:250-255(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
24.

"The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins."
Garzan J. , Rodriguez-Munoz M. , Lopez-Fando A. , Sanchez-Blazquez P.
Neuropsychopharmacology30:1632-1648(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RGS17 AND RGS20
25.

"mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis."
Rios C. , Gomes I. , Devi L.A.
Br. J. Pharmacol.148:387-395(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
26.

"RGS9-2 is a negative modulator of mu-opioid receptor function."
Psifogeorgou K. , Papakosta P. , Russo S.J. , Neve R.L. , Kardassis D. , Gold S.J. , Zachariou V.
J. Neurochem.103:617-625(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RGS9
27.

"Multiple actions of spinophilin regulate mu opioid receptor function."
Charlton J.J. , Allen P.B. , Psifogeorgou K. , Chakravarty S. , Gomes I. , Neve R.L. , Devi L.A. , Greengard P. , Nestler E.J. , Zachariou V.
Neuron58:238-247(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R9B
28.

"Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4."
Decaillot F.M. , Rozenfeld R. , Gupta A. , Devi L.A.
Proc. Natl. Acad. Sci. U.S.A.105:16045-16050(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;RECEPTOR HETEROOLIGOMERIZATION;INTERACTION WITH OPRD1 AND RTP4
29.

"Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids."
Liu X.Y. , Liu Z.C. , Sun Y.G. , Ross M. , Kim S. , Tsai F.F. , Li Q.F. , Jeffry J. , Kim J.Y. , Loh H.H. , Chen Z.F.
Cell147:447-458(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 9);INTERACTION WITH GRPR
30.

"The histidine triad nucleotide-binding protein 1 supports mu-opioid receptor-glutamate NMDA receptor cross-regulation."
Rodriguez-Munoz M. , Sanchez-Blazquez P. , Vicente-Sanchez A. , Bailon C. , Martin-Aznar B. , Garzon J.
Cell. Mol. Life Sci.68:2933-2949(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HINT1
31.

"Heteromerization of the mu- and delta-opioid receptors produces ligand-biased antagonism and alters mu-receptor trafficking."
Milan-Lobo L. , Whistler J.L.
J. Pharmacol. Exp. Ther.337:868-875(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR HETEROOLIGOMERIZATION;FUNCTION;INTERACTION WITH OPRD1
32.

"Crystal structure of the micro-opioid receptor bound to a morphinan antagonist."
Manglik A. , Kruse A.C. , Kobilka T.S. , Thian F.S. , Mathiesen J.M. , Sunahara R.K. , Pardo L. , Weis W.I. , Kobilka B.K. , Granier S.
Nature485:321-326(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 52-360 IN COMPLEX WITH MORPHINAN ANTAGONIST;FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;DISULFIDE BOND

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