Gene name:
HCRT (OX;PPORX;PPOX) ;
Protein name:
Orexin ;
Alternative:
Hypocretin (Hcrt) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Subcellular Location:
Rough endoplasmic reticulum
Cytoplasmic vesicle
Cell junction
synapse
Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Protein Attributes:
50:
MNLPSTKVSW | AAVTLLLLLL | LLPPALLSSG | AAAQPLPDCC | RQKTCSCRLY |
100:
ELLHGAGNHA | AGILTLGKRR | SGPPGLQGRL | QRLLQASGNH | AAGILTMGRR |
131:
AGAEPAPRPC | LGRRCSAPAA | ASVAPGGQSG | I
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Pig
Dog
ELISA Kit for Human Orexin
ELISA Kit for Human Orexin
ELISA Kit for Human Orexin
ELISA Kit for Human Orexin
ELISA Kit for Human Orexin
ELISA Kit for Human Orexin
CLIA Kit for Human Orexin
CLIA Kit for Human Orexin
CLIA Kit for Human Orexin
CLIA Kit for Human Orexin
CLIA Kit for Human Orexin
CLIA Kit for Human Orexin
Polyclonal Antibody for Human Orexin
Polyclonal Antibody for Human Orexin
Polyclonal Antibody for Human Orexin
Polyclonal Antibody for Human Orexin
Polyclonal Antibody for Human Orexin
Polyclonal Antibody for Human Orexin
Monoclonal Antibody for Human Orexin
Monoclonal Antibody for Human Orexin
Monoclonal Antibody for Human Orexin
Monoclonal Antibody for Human Orexin
Monoclonal Antibody for Human Orexin
Monoclonal Antibody for Human Orexin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
Sakurai T.
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Amemiya A.
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Ishii M.
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Matsuzaki I.
,
Chemelli R.M.
,
Tanaka H.
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Williams S.C.
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Richardson J.A.
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Kozlowski G.P.
,
Wilson S.
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Arch J.R.S.
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Buckingham R.E.
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Haynes A.C.
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Carr S.A.
,
Annan R.S.
,
McNulty D.E.
,
Liu W.-S.
,
Terrett J.A.
,
Elshourbagy N.A.
,
Bergsma D.J.
,
Yanagisawa M.
more...
Cell92:573-585(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 70-97
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 34-66;DISULFIDE BONDS
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-12 IN COMPLEX OF HLA-DQA1/HLA-DQB1 HETERODIMER (HLA-DQ0602)
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 35-66;DISULFIDE BONDS
9.
"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains."
Peyron C.
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Faraco J.
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Rogers W.
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Ripley B.
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Overeem S.
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Charnay Y.
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Nevsimalova S.
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Aldrich M.
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Reynolds D.
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Albin R.
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Li R.
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Hungs M.
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Pedrazzoli M.
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Padigaru M.
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Kucherlapati M.
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Fan J.
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Maki R.
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Kucherlapati R.
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Nishino S.
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Mignot E.
more...
Nat. Med.6:991-997(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF VARIANT NRCLP1 ARG-16