Gene name:
Hcrt (Ox;Ppox) ;
Protein name:
Orexin ;
Alternative:
Hypocretin (Hcrt) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Subcellular Location:
Rough endoplasmic reticulum
Cytoplasmic vesicle
Cell junction
synapse
Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Protein Attributes:
50:
MNFPSTKVPW | AAVTLLLLLL | LPPALLSLGV | DAQPLPDCCR | QKTCSCRLYE |
100:
LLHGAGNHAA | GILTLGKRRP | GPPGLQGRLQ | RLLQANGNHA | AGILTMGRRA |
130:
GAELEPHPCS | GRGCPTVTTT | ALAPRGGSGV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Pig
Dog
ELISA Kit for Mouse Orexin
ELISA Kit for Mouse Orexin
ELISA Kit for Mouse Orexin
ELISA Kit for Mouse Orexin
ELISA Kit for Mouse Orexin
ELISA Kit for Mouse Orexin
CLIA Kit for Mouse Orexin
CLIA Kit for Mouse Orexin
CLIA Kit for Mouse Orexin
CLIA Kit for Mouse Orexin
CLIA Kit for Mouse Orexin
CLIA Kit for Mouse Orexin
Polyclonal Antibody for Mouse Orexin
Polyclonal Antibody for Mouse Orexin
Polyclonal Antibody for Mouse Orexin
Polyclonal Antibody for Mouse Orexin
Polyclonal Antibody for Mouse Orexin
Polyclonal Antibody for Mouse Orexin
Monoclonal Antibody for Mouse Orexin
Monoclonal Antibody for Mouse Orexin
Monoclonal Antibody for Mouse Orexin
Monoclonal Antibody for Mouse Orexin
Monoclonal Antibody for Mouse Orexin
Monoclonal Antibody for Mouse Orexin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
Sakurai T.
,
Amemiya A.
,
Ishii M.
,
Matsuzaki I.
,
Chemelli R.M.
,
Tanaka H.
,
Williams S.C.
,
Richardson J.A.
,
Kozlowski G.P.
,
Wilson S.
,
Arch J.R.S.
,
Buckingham R.E.
,
Haynes A.C.
,
Carr S.A.
,
Annan R.S.
,
McNulty D.E.
,
Liu W.-S.
,
Terrett J.A.
,
Elshourbagy N.A.
,
Bergsma D.J.
,
Yanagisawa M.
more...
Cell92:573-585(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity."
de Lecea L.
,
Kilduff T.S.
,
Peyron C.
,
Gao X.-B.
,
Foye P.E.
,
Danielson P.E.
,
Fukuhara C.
,
Battenberg E.L.F.
,
Gautvik V.T.
,
Bartlett F.S. II
,
Frankel W.N.
,
van den Pol A.N.
,
Bloom F.E.
,
Gautvik K.M.
,
Sutcliffe J.G.
Proc. Natl. Acad. Sci. U.S.A.95:322-327(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW