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Index > Protein center > Hcrt(Gene name) > Rat
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  • Hcrt (Gene name),
  • Orexin (Protein name ),  OREX_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Hcrt(Ox;Ppox);
    Protein name:
    Orexin;
    Alternative:
    Hypocretin(Hcrt);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
    Subcellular Location:
    Rough endoplasmic reticulum Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
    Protein Attributes:
    Sequence length:
    130
    Sequence:
    50:
    MNLPSTKVPW | AAVTLLLLLL | LPPALLSLGV | DAQPLPDCCR | QKTCSCRLYE | 
    100:
    LLHGAGNHAA | GILTLGKRRP | GPPGLQGRLQ | RLLQANGNHA | AGILTMGRRA | 
    130:
    GAELEPYPCP | GRRCPTATAT | ALAPRGGSRV | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Orexin
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    E0777h
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    Packing:
    96T
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    ELISA Kit for Rat Orexin
    Cat.:
    E0777r
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    Packing:
    96T
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    ELISA Kit for Rat Orexin
    Cat.:
    E0777m
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    96T
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    ELISA Kit for Rat Orexin
    MSDS:
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    ELISA Kit for Rat Orexin
    Cat.:
    E0777p
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    Packing:
    96T
    ELISA Kit for Rat Orexin
    Cat.:
    E0777d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Orexin
    Cat.:
    U0777p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Orexin
    Cat.:
    U0777r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Orexin
    Cat.:
    U0777h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Orexin
    Cat.:
    U0777d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Orexin
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Orexin
    Cat.:
    U0777m
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    Packing:
    96T
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    Polyclonal Antibody for Rat Orexin
    Cat.:
    P0777Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Orexin
    Polyclonal Antibody for Rat Orexin
    Polyclonal Antibody for Rat Orexin
    Polyclonal Antibody for Rat Orexin
    Cat.:
    P0777Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Orexin
    Cat.:
    P0777Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Orexin
    Monoclonal Antibody for Rat Orexin
    Monoclonal Antibody for Rat Orexin
    Monoclonal Antibody for Rat Orexin
    Monoclonal Antibody for Rat Orexin
    Monoclonal Antibody for Rat Orexin
    Protein for Rat Orexin
    Protein for Rat Orexin
    Protein for Rat Orexin
    Protein for Rat Orexin
    Protein for Rat Orexin
    Protein for Rat Orexin

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    References
    1. 1.
      "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
      Sakurai T. , Amemiya A. , Ishii M. , Matsuzaki I. , Chemelli R.M. , Tanaka H. , Williams S.C. , Richardson J.A. , Kozlowski G.P. , Wilson S. , Arch J.R.S. , Buckingham R.E. , Haynes A.C. , Carr S.A. , Annan R.S. , McNulty D.E. , Liu W.-S. , Terrett J.A. , more...
      Cell92:573-585(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 33-65 AND 69-96;PYROGLUTAMATE FORMATION AT GLN-33;MASS SPECTROMETRY
      tissue: Brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
    3. 3.
      "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M. , Mignot E.
      Bioessays23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    4. 4.
      "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T. , Chemelli R.M. , Sinton C.M. , Yanagisawa M.
      Annu. Rev. Neurosci.24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
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