Gene name:
Hcrt (Ox;Ppox) ;
Protein name:
Orexin ;
Alternative:
Hypocretin (Hcrt) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
Subcellular Location:
Rough endoplasmic reticulum
Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
Protein Attributes:
50:
MNLPSTKVPW | AAVTLLLLLL | LPPALLSLGV | DAQPLPDCCR | QKTCSCRLYE |
100:
LLHGAGNHAA | GILTLGKRRP | GPPGLQGRLQ | RLLQANGNHA | AGILTMGRRA |
130:
GAELEPYPCP | GRRCPTATAT | ALAPRGGSRV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Pig
Dog
Polyclonal Antibody for Rat Orexin
Polyclonal Antibody for Rat Orexin
Polyclonal Antibody for Rat Orexin
Polyclonal Antibody for Rat Orexin
Polyclonal Antibody for Rat Orexin
Polyclonal Antibody for Rat Orexin
Monoclonal Antibody for Rat Orexin
Monoclonal Antibody for Rat Orexin
Monoclonal Antibody for Rat Orexin
Monoclonal Antibody for Rat Orexin
Monoclonal Antibody for Rat Orexin
Monoclonal Antibody for Rat Orexin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
Sakurai T.
,
Amemiya A.
,
Ishii M.
,
Matsuzaki I.
,
Chemelli R.M.
,
Tanaka H.
,
Williams S.C.
,
Richardson J.A.
,
Kozlowski G.P.
,
Wilson S.
,
Arch J.R.S.
,
Buckingham R.E.
,
Haynes A.C.
,
Carr S.A.
,
Annan R.S.
,
McNulty D.E.
,
Liu W.-S.
,
Terrett J.A.
,
Elshourbagy N.A.
,
Bergsma D.J.
,
Yanagisawa M.
more...
Cell92:573-585(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 33-65 AND 69-96;PYROGLUTAMATE FORMATION AT GLN-33;MASS SPECTROMETRY
tissue :
Brain .
2.
"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity."
de Lecea L.
,
Kilduff T.S.
,
Peyron C.
,
Gao X.-B.
,
Foye P.E.
,
Danielson P.E.
,
Fukuhara C.
,
Battenberg E.L.F.
,
Gautvik V.T.
,
Bartlett F.S. II
,
Frankel W.N.
,
van den Pol A.N.
,
Bloom F.E.
,
Gautvik K.M.
,
Sutcliffe J.G.
Proc. Natl. Acad. Sci. U.S.A.95:322-327(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW