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Index > Protein center > DDOST(Gene name) > Human
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  • DDOST (Gene name),
  • Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (Protein name ),  OST48_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    DDOST(OK/SW-cl.45;KIAA0115;OST48);
    Protein name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit(DDOST 48 kDa subunit;Oligosaccharyl transferase 48 kDa subunit);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes even after release from the ribosome.
    Function:
    Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose oligosaccharide to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    456
    Sequence:
    50:
    MGYFRCARAG | SFGRRRKMEP | STAARAWALF | WLLLPLLGAV | CASGPRTLVL | 
    100:
    LDNLNVRETH | SLFFRSLKDR | GFELTFKTAD | DPSLSLIKYG | EFLYDNLIIF | 
    150:
    SPSVEDFGGN | INVETISAFI | DGGGSVLVAA | SSDIGDPLRE | LGSECGIEFD | 
    200:
    EEKTAVIDHH | NYDISDLGQH | TLIVADTENL | LKAPTIVGKS | SLNPILFRGV | 
    250:
    GMVADPDNPL | VLDILTGSST | SYSFFPDKPI | TQYPHAVGKN | TLLIAGLQAR | 
    300:
    NNARVIFSGS | LDFFSDSFFN | SAVQKAAPGS | QRYSQTGNYE | LAVALSRWVF | 
    350:
    KEEGVLRVGP | VSHHRVGETA | PPNAYTVTDL | VEYSIVIQQL | SNGKWVPFDG | 
    400:
    DDIQLEFVRI | DPFVRTFLKK | KGGKYSVQFK | LPDVYGVFQF | KVDYNRLGYT | 
    450:
    HLYSSTQVSV | RPLQHTQYER | FIPSAYPYYA | SAFSMMLGLF | IFSIVFLHMK | 
    456:
    EKEKSD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093h
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    Packing:
    96T
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    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093m
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    96T
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    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093c
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    96T
    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093r
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    96T
    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093d
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    96T
    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093p
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    96T
    ELISA Kit for Human DDOST 48 kDa subunit
    Cat.:
    E2093b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human DDOST 48 kDa subunit
    Cat.:
    U2093m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Cat.:
    P2093Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Cat.:
    P2093Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Polyclonal Antibody for Human DDOST 48 kDa subunit
    Cat.:
    P2093Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Monoclonal Antibody for Human DDOST 48 kDa subunit
    Protein for Human DDOST 48 kDa subunit
    Protein for Human DDOST 48 kDa subunit
    Protein for Human DDOST 48 kDa subunit
    Cat.:
    R2093h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human DDOST 48 kDa subunit
    Protein for Human DDOST 48 kDa subunit
    Protein for Human DDOST 48 kDa subunit
    Protein for Human DDOST 48 kDa subunit

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    References
    1. 1.
      "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)."
      Yamagata T. , Tsuru T. , Momoi M.Y. , Suwa K. , Nozaki Y. , Mukasa T. , Ohashi H. , Fukushima Y. , Momoi T.
      Genomics45:535-540(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-8
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
      DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-8
      tissue: Bone marrow.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT GLY-8
      tissue: Subthalamic nucleus.
      tissue: Synovium.
      tissue: Umbilical cord blood.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-8
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-8
      tissue: Brain.
    7. 7.
      "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S. , Itoh K.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-456 (ISOFORM 1)
      tissue: Colon adenocarcinoma.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis."
      Shchedrina V.A. , Everley R.A. , Zhang Y. , Gygi S.P. , Hatfield D.L. , Gladyshev V.N.
      J. Biol. Chem.286:42937-42948(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CANX; DERL1; DERL2; RPN1; RPN2; SELK; STT3A; VCP AND VIMP
    10. 10.
      "DDOST mutations identified by whole-exome sequencing are implicated in congenital disorders of glycosylation."
      Jones M.A. , Ng B.G. , Bhide S. , Chin E. , Rhodenizer D. , He P. , Losfeld M.E. , He M. , Raymond K. , Berry G. , Freeze H.H. , Hegde M.R.
      Am. J. Hum. Genet.90:363-368(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CDG1R ASP-217
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