P2RY12 ELISA Kit for Human(Homo sapiens) | EIAab.comP2RY12 ELISA Kit for Human(Homo sapiens)

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P2RY12 (Gene name),

P2Y purinoceptor 12 (Protein name ), P2Y12_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

P2RY12(HORK3);

Protein name:

P2Y purinoceptor 12(P2Y12);

Alternative:

P2T(AC);ADP-glucose receptor(ADPG-R);P2Y(cyc);P2Y(AC);SP1999;P2Y12 platelet ADP receptor(P2Y(ADP));

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

342

Sequence:

50:

100:

150:

200:

250:

300:

342:

LCKSFRNSLI | SMLKCPNSAT | SLSQDNRKKE | QDGGDPNEET | PM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:64805

STRING:

9606.ENSP00000307259

UniGene:

Hs.591281

MIM:

600515

Pfam:

PF00001

SMR:

Q9H244

String:

Q9H244

Uniprot:

Q9H244

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ELISA Kit for Human P2Y12

Cat.:

E12345h

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96T

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ELISA Kit for Human P2Y12

Cat.:

E12345r

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96T

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ELISA Kit for Human P2Y12

Cat.:

E12345m

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96T

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CLIA Kit for Human P2Y12

Cat.:

U12345r

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96T

CLIA Kit for Human P2Y12

Cat.:

U12345h

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96T

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CLIA Kit for Human P2Y12

Cat.:

U12345m

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Packing:

96T

Polyclonal Antibody for Human P2Y12

Cat.:

P12345Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human P2Y12

Monoclonal Antibody for Human P2Y12

Protein for Human P2Y12

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Identification of the platelet ADP receptor targeted by antithrombotic drugs."
Hollopeter G. , Jantzen H.-M. , Vincent D. , Li G. , England L. , Ramakrishnan V. , Yang R.-B. , Nurden P. , Nurden A. , Julius D.J. , Conley P.B.
Nature409:202-207(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INVOLVEMENT IN BDPLT8
2.

"ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999."
Zhang F.L. , Luo L. , Gustafson E. , Lachowicz J. , Smith M. , Qiao X. , Liu Y.-H. , Chen G. , Pramanik B. , Laz T.M. , Palmer K. , Bayne M. , Monsma F.J. Jr.
J. Biol. Chem.276:8608-8615(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
tissue: Hypothalamus.
3.

"Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y1 receptor."
Takasaki J. , Kamohara M. , Saito T. , Matsumoto M. , Matsumoto S. , Ohishi T. , Soga T. , Matsushime H. , Furuichi K.
Mol. Pharmacol.60:432-439(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
tissue: Brain.
4.

"ADP-glucose activates a G-protein coupled receptor and inhibits smooth muscle contractions."
Reinscheid R.K. , Nothacker H.-P. , Wang Z. , Zeng J. , Ehlert F.J. , Civelli O.
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Cloning and characterization of a human platelet ADP-receptor."
Bruess M. , von Kugelgen I. , Bonisch H.
Submitted (2002-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Blood.
6.

"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S. , Kadowaki S. , Haga T. , Takaesu H. , Mitaku S.
FEBS Lett.520:97-101(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Prostate.
10.

"Structure of the human P2Y12 receptor in complex with an antithrombotic drug."
Zhang K. , Zhang J. , Gao Z.G. , Zhang D. , Zhu L. , Han G.W. , Moss S.M. , Paoletta S. , Kiselev E. , Lu W. , Fenalti G. , Zhang W. , Mueller C.E. , Yang H. , Jiang H. , Cherezov V. , Katritch V. , Jacobson K.A. , more...
Nature509:115-118(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) IN COMPLEX WITH THE AGONIST AZD1283;FUNCTION;DISULFIDE BOND;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-80; SER-156; ASN-159; LYS-280 AND GLU-281
11.

"Agonist-bound structure of the human P2Y12 receptor."
Zhang J. , Zhang K. , Gao Z.G. , Paoletta S. , Zhang D. , Han G.W. , Li T. , Ma L. , Zhang W. , Mueller C.E. , Yang H. , Jiang H. , Cherezov V. , Katritch V. , Jacobson K.A. , Stevens R.C. , Wu B. , Zhao Q.
Nature509:119-122(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-342 IN COMPLEX WITH THE ADP ANALOG 2-(METHYLSULFANYL)ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE);FUNCTION;SUBCELLULAR LOCATION;DISULFIDE BOND;MUTAGENESIS OF SER-83; CYS-97; CYS-175; ARG-256 AND LYS-280
12.

"Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding."
Cattaneo M. , Zighetti M.L. , Lombardi R. , Martinez C. , Lecchi A. , Conley P.B. , Ware J. , Ruggeri Z.M.
Proc. Natl. Acad. Sci. U.S.A.100:1978-1983(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BDPLT8 GLN-256 AND TRP-265;FUNCTION;SUBCELLULAR LOCATION

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