Tp53 ELISA Kit for Mouse(Mus musculus) | EIAab.comTp53 ELISA Kit for Mouse(Mus musculus)

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Tp53 (Gene name),

Cellular tumor antigen p53 (Protein name ), P53_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Tp53(P53;Trp53);

Protein name:

Cellular tumor antigen p53;

Alternative:

Tumor suppressor p53;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds DNA as a homotetramer. Found in a complex with CABLES1 and TP73. Interacts with histone acetyltransferases EP300 and methyltransferases HRMT1L2 and CARM1, and recruits them to promoters. The C-terminus interacts with TAF1, when TAF1 is part of the TFIID complex. Interacts with HIPK1, HIPK2, AXIN1, and P53DINP1. Part of a complex consisting of TP53, HIPK2 and AXIN1. Interacts with WWOX. Interacts with USP7 and SYVN1. Interacts with HSP90AB1. Interacts with YWHAZ; the interaction enhances TP53 transcriptional activity. Phosphorylation of YWHAZ on 'Ser-58' inhibits this interaction (By similarity). Interacts with PML (via C-terminus). Interacts with MDM2; leading to ubiquitination and proteasomal degradation of TP53. Directly interacts with FBXO42; leading to ubiquination and degradation of TP53. Interacts with DAXX. Interacts (when monomethylated at Lys-376) with L3MBTL1 (By similarity). Interacts with BANP, CDKN2AIP, NUAK1, STK11/LKB1 and E4F1. Interacts with CHD8, leading to recruit histone H1 and prevent transactivation activity. Interacts with AURKA, TRIM24 and BRD7. Interacts with GRK5. Binds to the CAK complex (CDK7, cyclin H and MAT1) in response to DNA damage. Interacts with CDK5 in neurons. Phosphorylated at Ser-309 and Ser-386 by CDK2 in response to DNA-damage.

Function:

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.

Subcellular Location:

Cytoplasm Nucleus Endoplasmic reticulum Nucleus PML body Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2.

Protein Attributes:

Sequence length:

387

Sequence:

50:

100:

150:

200:

250:

300:

350:

387:

EESGDSRAHS | SYLKTKKGQS | TSRHKKTMVK | KVGPDSD

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

UniGene:

Mm.222

SMR:

P02340

Pfam:

PF00870

STRING:

10090.ENSMUSP00000104298

String:

P02340

KEGG:

mmu:22059

Uniprot:

P02340

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ELISA Kit for Mouse Cellular tumor antigen p53

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E0928r

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ELISA Kit for Mouse Cellular tumor antigen p53

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E0928h

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ELISA Kit for Mouse Cellular tumor antigen p53

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E0928b

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ELISA Kit for Mouse Cellular tumor antigen p53

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E0928m

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ELISA Kit for Mouse Cellular tumor antigen p53

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E0928p

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ELISA Kit for Mouse Cellular tumor antigen p53

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ELISA Kit for Mouse Cellular tumor antigen p53

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E0928c

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96T

ELISA Kit for Mouse Cellular tumor antigen p53

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E0928d

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96T

CLIA Kit for Mouse Cellular tumor antigen p53

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U0928b

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96T

CLIA Kit for Mouse Cellular tumor antigen p53

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U0928m

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96T

CLIA Kit for Mouse Cellular tumor antigen p53

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U0928d

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96T

CLIA Kit for Mouse Cellular tumor antigen p53

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U0928h

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96T

CLIA Kit for Mouse Cellular tumor antigen p53

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U0928p

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96T

CLIA Kit for Mouse Cellular tumor antigen p53

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CLIA Kit for Mouse Cellular tumor antigen p53

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U0928r

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CLIA Kit for Mouse Cellular tumor antigen p53

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U0928c

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Polyclonal Antibody for Mouse Cellular tumor antigen p53

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P0928Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Cellular tumor antigen p53

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P0928Rb-h

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Polyclonal Antibody for Mouse Cellular tumor antigen p53

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P0928Rb-m

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Polyclonal Antibody for Mouse Cellular tumor antigen p53

Monoclonal Antibody for Mouse Cellular tumor antigen p53

Protein for Mouse Cellular tumor antigen p53

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Analysis of the gene coding for the murine cellular tumour antigen p53."
Bienz B. , Zakut-Houri R. , Givol D. , Oren M.
EMBO J.3:2179-2183(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"A single gene and a pseudogene for the cellular tumour antigen p53."
Zakut-Houri R. , Oren M. , Bienz B. , Lavie V. , Hazum S. , Givol D.
Nature306:594-597(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53."
Jenkins J.R. , Rudge K. , Redmond S. , Wade-Evans A.
Nucleic Acids Res.12:5609-5626(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Immunologically distinct p53 molecules generated by alternative splicing."
Arai N. , Nomura D. , Yokota K. , Wolf D. , Brill E. , Shohat O. , Rotter V.
Mol. Cell. Biol.6:3232-3239(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CLONES PCD53; P53-M11 AND P53-M8)
5.

"Primary structure of DNA complementary to mRNA of murine oncoprotein p53."
Chumakov P.M.
Bioorg. Khim.13:1691-1694(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT VAL-132
6.

"Cell cycle in DNA-PKcs knock-out mice."
Araki R. , Fukumura R. , Fujimori A. , Tatsumi K. , Abe M.
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: SCID.
7.

"DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage."
Jimenez G.S. , Bryntesson F. , Torres-Arzayus M.I. , Priestley A. , Beeche M. , Saito S. , Sakaguchi K. , Appella E. , Jeggo P.A. , Taccioli G.E. , Wahl G.M. , Hubank M.
Nature400:81-83(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
8.

"Characterization of DNA-PKcs null mutant SX9."
Araki R. , Fukumura R. , Fujimori A. , Tatsumi K. , Abe M.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Mammary carcinoma.
9.

"p53 in 129-SVJ mice."
Fujimori A. , Abe M.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: 129/SvJ.
tissue: Lung fibroblast.
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary gland.
11.

"Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice."
Burns P.A. , Kemp C.J. , Gannon J.V. , Lane D.P. , Bremner R. , Balmain A.
Oncogene6:2363-2369(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-255
12.

"Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse."
DeLeo A.B. , Jay G. , Appella E. , Dubois G.C. , Law L.W. , Old L.J.
Proc. Natl. Acad. Sci. U.S.A.76:2420-2424(1979) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISCOVERY OF P53
13.

"p53 is involved in the p120E4F-mediated growth arrest."
Sandy P. , Gostissa M. , Fogal V. , Cecco L.D. , Szalay K. , Rooney R.J. , Schneider C. , Del Sal G.
Oncogene19:188-199(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH E4F1
14.

"Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)."
Kondo S. , Lu Y. , Debbas M. , Lin A.W. , Sarosi I. , Itie A. , Wakeham A. , Tuan J. , Saris C. , Elliott G. , Ma W. , Benchimol S. , Lowe S.W. , Mak T.W. , Thukral S.K.
Proc. Natl. Acad. Sci. U.S.A.100:5431-5436(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIPK1;PHOSPHORYLATION
15.

"Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation."
Rui Y. , Xu Z. , Lin S. , Li Q. , Rui H. , Luo W. , Zhou H.-M. , Cheung P.-Y. , Wu Z. , Ye Z. , Li P. , Han J. , Lin S.-C.
EMBO J.23:4583-4594(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1;IDENTIFICATION IN A COMPLEX WITH HIPK2 AND AXIN1
16.

"Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells."
Samad A. , Anderson C.W. , Carroll R.B.
Proc. Natl. Acad. Sci. U.S.A.83:897-901(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-309 AND SER-386;RNA-BINDING
17.

"The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II."
Meek D.W. , Simon S. , Kikkawa U. , Eckhart W.
EMBO J.9:3253-3260(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-386
18.

"p53 is covalently linked to 5.8S rRNA."
Fontoura B.M. , Sorokina E.A. , David E. , Carroll R.B.
Mol. Cell. Biol.12:5145-5151(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PUTATIVE RNA-BINDING
19.

"Negative control of p53 by Sir2alpha promotes cell survival under stress."
Luo J. , Nikolaev A.Y. , Imai S. , Chen D. , Su F. , Shiloh A. , Guarente L. , Gu W.
Cell107:137-148(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEACETYLATION BY SIRT1
20.

"Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination."
Lim S.-K. , Shin J.-M. , Kim Y.-S. , Baek K.-H.
Int. J. Oncol.24:357-364(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP7
21.

"Differential effect of ik3-1/cables on p53- and p73-induced cell death."
Tsuji K. , Mizumoto K. , Yamochi T. , Nishimoto I. , Matsuoka M.
J. Biol. Chem.277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CABLES1 AND TP73
22.

"Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice."
Kaul R. , Mukherjee S. , Ahmed F. , Bhat M.K. , Chhipa R. , Galande S. , Chattopadhyay S.
Int. J. Cancer103:606-615(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BANP
23.

"PML regulates p53 stability by sequestering Mdm2 to the nucleolus."
Bernardi R. , Scaglioni P.P. , Bergmann S. , Horn H.F. , Vousden K.H. , Pandolfi P.P.
Nat. Cell Biol.6:665-672(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-15;LYSINE ACETYLATION;UBIQUITINATION;SUBCELLULAR LOCATION
24.

"PRAK is essential for ras-induced senescence and tumor suppression."
Sun P. , Yoshizuka N. , New L. , Moser B.A. , Li Y. , Liao R. , Xie C. , Chen J. , Deng Q. , Yamout M. , Dong M.Q. , Frangou C.G. , Yates J.R. III , Wright P.E. , Han J.
Cell128:295-308(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-34
25.

"Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation."
Das S. , Raj L. , Zhao B. , Kimura Y. , Bernstein A. , Aaronson S.A. , Lee S.W.
Cell130:624-637(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF385A
26.

"Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9."
Arai S. , Matsushita A. , Du K. , Yagi K. , Okazaki Y. , Kurokawa R.
FEBS Lett.581:5649-5657(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-9
27.

"CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis."
Nishiyama M. , Oshikawa K. , Tsukada Y.I. , Nakagawa T. , Iemura S. , Natsume T. , Fan Y. , Kikuchi A. , Skoultchi A.I. , Nakayama K.I.
Nat. Cell Biol.11:172-182(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHD8
28.

"Trim24 targets endogenous p53 for degradation."
Allton K. , Jain A.K. , Herz H.M. , Tsai W.W. , Jung S.Y. , Qin J. , Bergmann A. , Johnson R.L. , Barton M.C.
Proc. Natl. Acad. Sci. U.S.A.106:11612-11616(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION;INTERACTION WITH TRIM24
29.

"A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response."
Huarte M. , Guttman M. , Feldser D. , Garber M. , Koziol M.J. , Kenzelmann-Broz D. , Khalil A.M. , Zuk O. , Amit I. , Rabani M. , Attardi L.D. , Regev A. , Lander E.S. , Jacks T. , Rinn J.L.
Cell142:409-419(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"p53 opens the mitochondrial permeability transition pore to trigger necrosis."
Vaseva A.V. , Marchenko N.D. , Ji K. , Tsirka S.E. , Holzmann S. , Moll U.M.
Cell149:1536-1548(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
31.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-315;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
32.

"Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution."
Zhao K. , Chai X. , Johnston K. , Clements A. , Marmorstein R.
J. Biol. Chem.276:12120-12127(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 96-281
33.

"High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds."
Ho W.C. , Luo C. , Zhao K. , Chai X. , Fitzgerald M.X. , Marmorstein R.
Acta Crystallogr. D62:1484-1493(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 92-289
34.

"Structure of the p53 core domain dimer bound to DNA."
Ho W.C. , Fitzgerald M.X. , Marmorstein R.
J. Biol. Chem.281:20494-20502(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 92-289 IN COMPLEX WITH DNA AND ZINC IONS;SUBUNIT
35.

"Crystal structure of the mouse p53 core domain in zinc-free state."
Kwon E. , Kim D.Y. , Suh S.W. , Kim K.K.
Proteins70:280-283(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 92-284
36.

"Crystal structure of a p53 core tetramer bound to DNA."
Malecka K.A. , Ho W.C. , Marmorstein R.
Oncogene28:325-333(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 93-289 IN COMPLEX WITH DNA;SUBUNIT

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