PA2G4 ELISA Kit for Human(Homo sapiens) | EIAab.comPA2G4 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > PA2G4(Gene name) > Human

PA2G4 (Gene name),

Proliferation-associated protein 2G4 (Protein name ), PA2G4_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

PA2G4(EBP1);

Protein name:

Proliferation-associated protein 2G4;

Alternative:

ErbB3-binding protein 1;Cell cycle protein p38-2G4 homolog(hG4-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation.

Function:

May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

Subcellular Location:

Cytoplasm Nucleus nucleolus Tranlocates to the nucleus upon treatment with HRG.

Protein Attributes:

Sequence length:

394

Sequence:

50:

100:

150:

200:

250:

300:

350:

394:

DAELKALLQS | SASRKTQKKK | KKKASKTAEN | ATSGETLEEN | EAGD

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

Q9UQ80

UniGene:

Hs.524498

Pfam:

PF00557

STRING:

9606.ENSP00000302886

KEGG:

hsa:5036

MIM:

602145

String:

Q9UQ80

Uniprot:

Q9UQ80

FOR

ELISA Kit for Human Proliferation-associated protein 2G4

Cat.:

E1733h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Proliferation-associated protein 2G4

Cat.:

E1733m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Proliferation-associated protein 2G4

Cat.:

U1733h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Proliferation-associated protein 2G4

Cat.:

U1733m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Proliferation-associated protein 2G4

Cat.:

P1733Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Proliferation-associated protein 2G4

Cat.:

P1733Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Proliferation-associated protein 2G4

Protein for Human Proliferation-associated protein 2G4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4."
Lamartine J. , Seri M. , Cinti R. , Heitzmann F. , Creaven M. , Radomski N. , Jost E. , Lenoir G.M. , Romeo G. , Sylla B.S.
Cytogenet. Cell Genet.78:31-35(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin."
Yoo J.Y. , Wang X.W. , Rishi A.K. , Lessor T. , Xia X.M. , Gustafson T.A. , Hamburger A.W.
Br. J. Cancer82:683-690(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH ERBB3;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Brain.
3.

"Genomic structure of the human PA2G4 gene."
Caroli F. , Lamartine J. , Sylla B.S. , Romeo G. , Seri M.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
tissue: Skin.
5.

Bienvenut W.V. , Matallanas D. , Cooper W.N. , Boldt K. , von Kriegsheim A.F. , Kolch W.
Submitted (2010-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-20; 23-30; 34-62; 73-101; 156-172; 200-211; 216-236; 264-281 AND 299-364;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: B-cell lymphoma.
tissue: Mammary carcinoma.
tissue: Ovarian carcinoma.
6.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-51; 216-236; 264-271; 299-311; 333-344 AND 377-394;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
7.

"Regulation of the ErbB3 binding protein Ebp1 by protein kinase C."
Lessor T.J. , Hamburger A.W.
Mol. Cell. Endocrinol.175:185-191(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB3;PHOSPHORYLATION;PHOSPHORYLATION BY PKC;PHOSPHORYLATION AT THR-366;MUTAGENESIS OF SER-363 AND THR-366
8.

"Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation."
Xia X. , Cheng A. , Lessor T. , Zhang Y. , Hamburger A.W.
J. Cell. Physiol.187:209-217(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION REPRESSION;INTERACTION WITH RB1
9.

"Functional proteomic analysis of human nucleolus."
Scherl A. , Coute Y. , Deon C. , Calle A. , Kindbeiter K. , Sanchez J.-C. , Greco A. , Hochstrasser D.F. , Diaz J.-J.
Mol. Biol. Cell13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases."
Zhang Y. , Woodford N. , Xia X. , Hamburger A.W.
Nucleic Acids Res.31:2168-2177(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN E2F1-MEDIATED TRANSCRIPTION REPRESSION;INTERACTION WITH HDAC2
11.

"EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes."
Squatrito M. , Mancino M. , Donzelli M. , Areces L.B. , Draetta G.F.
Oncogene23:4454-4465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RRNA PROCESSING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;RNA-BINDING;IDENTIFICATION IN A RIBONUCLEOPROTEIN COMPLEX;ASSOCIATION WITH RRNA;ASSOCIATION WITH U3 SNORNA;MUTAGENESIS OF 20-LYS--LYS-22 AND 364-ARG-LYS-365
12.

"Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling."
Zhang Y. , Hamburger A.W.
Br. J. Cancer92:140-146(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION REPRESSION;INTERACTION WITH ERBB3 AND AR
13.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND THR-386;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-386;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Ebp1 isoforms distinctively regulate cell survival and differentiation."
Liu Z. , Ahn J.Y. , Liu X. , Ye K.
Proc. Natl. Acad. Sci. U.S.A.103:10917-10922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;INTERACTION WITH ERBB3;PHOSPHORYLATION AT SER-361;MUTAGENESIS OF SER-361
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361 AND THR-386;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor."
Liu Z. , Oh S.M. , Okada M. , Liu X. , Cheng D. , Peng J. , Brat D.J. , Sun S.Y. , Zhou W. , Gu W. , Ye K.
Mol. Biol. Cell20:757-768(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYUBIQUITINATION;SUBCELLULAR LOCATION;INTERACTION WITH RNF20 AND HUWE1;TISSUE SPECIFICITY;MUTAGENESIS OF SER-361
19.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-386;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
20.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-361 AND THR-386;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND THR-386;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions."
Kowalinski E. , Bange G. , Bradatsch B. , Hurt E. , Wild K. , Sinning I.
FEBS Lett.581:4450-4454(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS);INTERACTION WITH 5S RIBOSOMAL RNA;LACK OF METAL COFACTOR;LACK OF AMINOPEPTIDASE ACTIVITY

Product Feedback Wall

* Email:
*Comments: