PCNA-associated factor (Protein name
), PAF15_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
KIAA0101(L5;NS5ATP9;PAF);
Protein name:
PCNA-associated factor;
Alternative:
Overexpressed in anaplastic thyroid carcinoma 1(OEATC-1);Hepatitis C virus NS5A-transactivated protein 9(HCV NS5A-transactivated protein 9);PCNA-associated factor of 15 kDa(PAF15);
Organism:
PAF (Homo sapiens).
General Annotation
Sub Unit:
Interacts (when monoubiquitinated at Lys-15 and Lys-24) with PCNA. Interacts with isoform 2/p33ING1b of ING1. Interacts with BRCA1.
Function:
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Subcellular Location:
Nucleus
Cytoplasm
Perinuclear region
Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region.
Polyclonal Antibody for Human PCNA-associated factor
Monoclonal Antibody for Human PCNA-associated factor
Monoclonal Antibody for Human PCNA-associated factor
Monoclonal Antibody for Human PCNA-associated factor
Monoclonal Antibody for Human PCNA-associated factor
Protein for Human PCNA-associated factor
Protein for Human PCNA-associated factor
Protein for Human PCNA-associated factor
Protein for Human PCNA-associated factor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Cloning and identification of human gene 9 transactivated by hepatitis C virus NS5A protein." Liu Y.
,
Cheng J.
,
Wang G.
,
Wang J.
,
Zhang L.
,
Chen J.
,
Li L.
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH PCNA;MUTAGENESIS OF ILE-65 AND PHE-68
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Cited for: SUBCELLULAR LOCATION;INTERACTION WITH ING1 AND PCNA;INDUCTION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1
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Cited for: UBIQUITINATION;INTERACTION WITH PCNA;MUTAGENESIS OF 93-LYS--LYS-97
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Cited for: SUBCELLULAR LOCATION;INTERACTION WITH PCNA;UBIQUITINATION;PHOSPHORYLATION AT SER-31 AND SER-72;MUTAGENESIS OF 68-PHE-PHE-69 AND LYS-78
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PCNA;UBIQUITINATION AT LYS-15 AND LYS-24;MUTAGENESIS OF LYS-15 AND LYS-24