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Index > Protein center > PLA2G7(Gene name) > Human
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  • PLA2G7 (Gene name),
  • Platelet-activating factor acetylhydrolase (Protein name ),  PAFA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    PLA2G7(PAFAH);
    Protein name:
    Platelet-activating factor acetylhydrolase(PAF acetylhydrolase);
    Alternative:
    2-acetyl-1-alkylglycerophosphocholine esterase;1-alkyl-2-acetylglycerophosphocholine esterase;LDL-associated phospholipase A2(LDL-PLA(2));Group-VIIA phospholipase A2(gVIIA-PLA2);PAF 2-acylhydrolase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    441
    Sequence:
    50:
    MVPPKLHVLF | CLCGCLAVVY | PFDWQYINPV | AHMKSSAWVN | KIQVLMAAAS | 
    100:
    FGQTKIPRGN | GPYSVGCTDL | MFDHTNKGTF | LRLYYPSQDN | DRLDTLWIPN | 
    150:
    KEYFWGLSKF | LGTHWLMGNI | LRLLFGSMTT | PANWNSPLRP | GEKYPLVVFS | 
    200:
    HGLGAFRTLY | SAIGIDLASH | GFIVAAVEHR | DRSASATYYF | KDQSAAEIGD | 
    250:
    KSWLYLRTLK | QEEETHIRNE | QVRQRAKECS | QALSLILDID | HGKPVKNALD | 
    300:
    LKFDMEQLKD | SIDREKIAVI | GHSFGGATVI | QTLSEDQRFR | CGIALDAWMF | 
    350:
    PLGDEVYSRI | PQPLFFINSE | YFQYPANIIK | MKKCYSPDKE | RKMITIRGSV | 
    400:
    HQNFADFTFA | TGKIIGHMLK | LKGDIDSNVA | IDLSNKASLA | FLQKHLGLHK | 
    441:
    DFDQWDCLIE | GDDENLIPGT | NINTTNQHIM | LQNSSGIEKY | N
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    MIM:
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human PAF acetylhydrolase
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    ELISA Kit for Human PAF acetylhydrolase
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    ELISA Kit for Human PAF acetylhydrolase
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    ELISA Kit for Human PAF acetylhydrolase
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    E0867d
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    ELISA Kit for Human PAF acetylhydrolase
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    E0867c
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    CLIA Kit for Human PAF acetylhydrolase
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    U0867c
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    MSDS:
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    96T
    CLIA Kit for Human PAF acetylhydrolase
    Cat.:
    U0867m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PAF acetylhydrolase
    Cat.:
    U0867h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PAF acetylhydrolase
    Cat.:
    U0867b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PAF acetylhydrolase
    Cat.:
    U0867d
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PAF acetylhydrolase
    Polyclonal Antibody for Human PAF acetylhydrolase
    Cat.:
    P0867Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PAF acetylhydrolase
    Polyclonal Antibody for Human PAF acetylhydrolase
    Cat.:
    P0867Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PAF acetylhydrolase
    Monoclonal Antibody for Human PAF acetylhydrolase
    Monoclonal Antibody for Human PAF acetylhydrolase
    Monoclonal Antibody for Human PAF acetylhydrolase
    Monoclonal Antibody for Human PAF acetylhydrolase
    Monoclonal Antibody for Human PAF acetylhydrolase
    Protein for Human PAF acetylhydrolase
    Protein for Human PAF acetylhydrolase
    Protein for Human PAF acetylhydrolase
    Protein for Human PAF acetylhydrolase
    Protein for Human PAF acetylhydrolase

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 42-57
      tissue: Myeloid.
    2. 2.
      "Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins."
      Tew D.G. , Southan C. , Rice S.Q.J. , Lawrence M.P. , Li H. , Boyd H.F. , Moores K. , Gloger I.S. , Macphee C.H.
      Arterioscler. Thromb. Vasc. Biol.16:591-599(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Lymphoma.
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2007-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-45; HIS-92; ASN-191; THR-198 AND ALA-379
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-379
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-379
      tissue: Blood.
    7. 7.
      "Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad."
      Tjoelker L.W. , Eberhardt C. , Unger J. , le Trong H. , Zimmerman G.A. , McIntyre T.M. , Stafforini D.M. , Prescott S.M. , Gray P.W.
      J. Biol. Chem.270:25481-25487(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    8. 8.
      "Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis."
      Samanta U. , Bahnson B.J.
      J. Biol. Chem.283:31617-31624(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 47-429 ALONE AND IN COMPLEX WITH PARAOXON;ACTIVE SITE
    9. 9.
      "Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes."
      Samanta U. , Kirby S.D. , Srinivasan P. , Cerasoli D.M. , Bahnson B.J.
      Biochem. Pharmacol.78:420-429(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 47-429 IN COMPLEX WITH ORGANOPHOSPHORUS NERVE AGENTS
    10. 10.
      "Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase."
      Stafforini D.M. , Satoh K. , Atkinson D.L. , Tjoelker L.W. , Eberhardt C. , Yoshida H. , Imaizumi T. , Takamatsu S. , Zimmerman G.A. , McIntyre T.M. , Gray P.W. , Prescott S.M.
      J. Clin. Invest.97:2784-2791(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
    11. 11.
      "Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation."
      Yamada Y. , Yokota M.
      Biochem. Biophys. Res. Commun.236:772-775(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD ARG-281
    12. 12.
      "A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke."
      Hiramoto M. , Yoshida H. , Imaizumi T. , Yoshimizu N. , Satoh K.
      Stroke28:2417-2420(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
    13. 13.
      "Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men."
      Yamada Y. , Ichihara S. , Fujimura T. , Yokota M.
      Metabolism47:177-181(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
    14. 14.
      "A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension."
      Yoshida H. , Imaizumi T. , Fujimoto K. , Itaya H. , Hiramoto M. , Yoshimizu N. , Fukushi K. , Satoh K.
      Thromb. Haemost.80:372-375(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
    15. 15.
      "The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma."
      Kruse S. , Mao X.-Q. , Heinzmann A. , Blattmann S. , Roberts M.H. , Braun S. , Gao P.-S. , Forster J. , Kuehr J. , Hopkin J.M. , Shirakawa T. , Deichmann K.A.
      Am. J. Hum. Genet.66:1522-1530(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-92; THR-198 AND ALA-379;INVOLVEMENT IN ASTHMA AND ATOPY
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