Gene name:
PLA2G7 (PAFAH) ;
Protein name:
Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) ;
Alternative:
2-acetyl-1-alkylglycerophosphocholine esterase ;1-alkyl-2-acetylglycerophosphocholine esterase ;LDL-associated phospholipase A2 (LDL-PLA(2)) ;Group-VIIA phospholipase A2 (gVIIA-PLA2) ;PAF 2-acylhydrolase ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Subcellular Location:
Secreted
extracellular space
Protein Attributes:
50:
MVPPKLHVLF | CLCGCLAVVY | PFDWQYINPV | AHMKSSAWVN | KIQVLMAAAS |
100:
FGQTKIPRGN | GPYSVGCTDL | MFDHTNKGTF | LRLYYPSQDN | DRLDTLWIPN |
150:
KEYFWGLSKF | LGTHWLMGNI | LRLLFGSMTT | PANWNSPLRP | GEKYPLVVFS |
200:
HGLGAFRTLY | SAIGIDLASH | GFIVAAVEHR | DRSASATYYF | KDQSAAEIGD |
250:
KSWLYLRTLK | QEEETHIRNE | QVRQRAKECS | QALSLILDID | HGKPVKNALD |
300:
LKFDMEQLKD | SIDREKIAVI | GHSFGGATVI | QTLSEDQRFR | CGIALDAWMF |
350:
PLGDEVYSRI | PQPLFFINSE | YFQYPANIIK | MKKCYSPDKE | RKMITIRGSV |
400:
HQNFADFTFA | TGKIIGHMLK | LKGDIDSNVA | IDLSNKASLA | FLQKHLGLHK |
441:
DFDQWDCLIE | GDDENLIPGT | NINTTNQHIM | LQNSSGIEKY | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Dog
Chicken
ELISA Kit for Human PAF acetylhydrolase
ELISA Kit for Human PAF acetylhydrolase
ELISA Kit for Human PAF acetylhydrolase
ELISA Kit for Human PAF acetylhydrolase
ELISA Kit for Human PAF acetylhydrolase
CLIA Kit for Human PAF acetylhydrolase
CLIA Kit for Human PAF acetylhydrolase
CLIA Kit for Human PAF acetylhydrolase
CLIA Kit for Human PAF acetylhydrolase
CLIA Kit for Human PAF acetylhydrolase
Polyclonal Antibody for Human PAF acetylhydrolase
Polyclonal Antibody for Human PAF acetylhydrolase
Polyclonal Antibody for Human PAF acetylhydrolase
Polyclonal Antibody for Human PAF acetylhydrolase
Polyclonal Antibody for Human PAF acetylhydrolase
Monoclonal Antibody for Human PAF acetylhydrolase
Monoclonal Antibody for Human PAF acetylhydrolase
Monoclonal Antibody for Human PAF acetylhydrolase
Monoclonal Antibody for Human PAF acetylhydrolase
Monoclonal Antibody for Human PAF acetylhydrolase
Protein for Human PAF acetylhydrolase
Protein for Human PAF acetylhydrolase
Protein for Human PAF acetylhydrolase
Protein for Human PAF acetylhydrolase
Protein for Human PAF acetylhydrolase
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Bang O Y, Chung J W, Ryoo S, et al.
References
1.
"Anti-inflammatory properties of a platelet-activating factor acetylhydrolase."
Tjoelker L.W.
,
Wilder C.
,
Eberhardt C.
,
Stafforini D.M.
,
Dietsch G.
,
Schimpf B.
,
Hooper S.
,
le Trong H.
,
Cousens L.S.
,
Zimmerman G.A.
,
Yamada Y.
,
McIntyre T.M.
,
Prescott S.M.
,
Gray P.W.
Nature374:549-553(1995)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 42-57
tissue :
Myeloid .
2.
"Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins."
Tew D.G.
,
Southan C.
,
Rice S.Q.J.
,
Lawrence M.P.
,
Li H.
,
Boyd H.F.
,
Moores K.
,
Gloger I.S.
,
Macphee C.H.
Arterioscler. Thromb. Vasc. Biol.16:591-599(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue :
Lymphoma .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-45; HIS-92; ASN-191; THR-198 AND ALA-379
4.
"The DNA sequence and analysis of human chromosome 6."
Mungall A.J.
,
Palmer S.A.
,
Sims S.K.
,
Edwards C.A.
,
Ashurst J.L.
,
Wilming L.
,
Jones M.C.
,
Horton R.
,
Hunt S.E.
,
Scott C.E.
,
Gilbert J.G.R.
,
Clamp M.E.
,
Bethel G.
,
Milne S.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews T.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Blakey S.E.
,
Bray-Allen S.
,
Brook J.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clark G.
,
Clee C.M.
,
Clegg S.
,
Cobley V.
,
Collier R.E.
,
Collins J.E.
,
Colman L.K.
,
Corby N.R.
,
Coville G.J.
,
Culley K.M.
,
Dhami P.
,
Davies J.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.E.
,
Evans K.A.
,
Faulkner L.
,
Francis M.D.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Ghori M.J.
,
Gilby L.M.
,
Gillson C.J.
,
Glithero R.J.
,
Grafham D.V.
,
Grant M.
,
Gribble S.
,
Griffiths C.
,
Griffiths M.N.D.
,
Hall R.
,
Halls K.S.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Heathcott R.
,
Holmes S.J.
,
Howden P.J.
,
Howe K.L.
,
Howell G.R.
,
Huckle E.
,
Humphray S.J.
,
Humphries M.D.
,
Hunt A.R.
,
Johnson C.M.
,
Joy A.A.
,
Kay M.
,
Keenan S.J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.R.
,
Lloyd D.M.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Maslen G.L.
,
Matthews L.
,
McCann O.T.
,
McLaren S.J.
,
McLay K.
,
McMurray A.
,
Moore M.J.F.
,
Mullikin J.C.
,
Niblett D.
,
Nickerson T.
,
Novik K.L.
,
Oliver K.
,
Overton-Larty E.K.
,
Parker A.
,
Patel R.
,
Pearce A.V.
,
Peck A.I.
,
Phillimore B.J.C.T.
,
Phillips S.
,
Plumb R.W.
,
Porter K.M.
,
Ramsey Y.
,
Ranby S.A.
,
Rice C.M.
,
Ross M.T.
,
Searle S.M.
,
Sehra H.K.
,
Sheridan E.
,
Skuce C.D.
,
Smith S.
,
Smith M.
,
Spraggon L.
,
Squares S.L.
,
Steward C.A.
,
Sycamore N.
,
Tamlyn-Hall G.
,
Tester J.
,
Theaker A.J.
,
Thomas D.W.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
White S.S.
,
Whitehead S.L.
,
Whittaker H.
,
Wild A.
,
Willey D.J.
,
Wilmer T.E.
,
Wood J.M.
,
Wray P.W.
,
Wyatt J.C.
,
Young L.
,
Younger R.M.
,
Bentley D.R.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Dunham I.
,
Rogers J.
,
Beck S.
more...
Nature425:805-811(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-379
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-379
tissue :
Blood .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 47-429 ALONE AND IN COMPLEX WITH PARAOXON;ACTIVE SITE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 47-429 IN COMPLEX WITH ORGANOPHOSPHORUS NERVE AGENTS
10.
"Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase."
Stafforini D.M.
,
Satoh K.
,
Atkinson D.L.
,
Tjoelker L.W.
,
Eberhardt C.
,
Yoshida H.
,
Imaizumi T.
,
Takamatsu S.
,
Zimmerman G.A.
,
McIntyre T.M.
,
Gray P.W.
,
Prescott S.M.
J. Clin. Invest.97:2784-2791(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PAFAD PHE-279
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PAFAD ARG-281
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PAFAD PHE-279
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PAFAD PHE-279
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PAFAD PHE-279
15.
"The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma."
Kruse S.
,
Mao X.-Q.
,
Heinzmann A.
,
Blattmann S.
,
Roberts M.H.
,
Braun S.
,
Gao P.-S.
,
Forster J.
,
Kuehr J.
,
Hopkin J.M.
,
Shirakawa T.
,
Deichmann K.A.
Am. J. Hum. Genet.66:1522-1530(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HIS-92; THR-198 AND ALA-379;INVOLVEMENT IN ASTHMA AND ATOPY