PLA2G7 ELISA Kit for Human(Homo sapiens) | EIAab.comPLA2G7 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PLA2G7(Gene name) > Human

PLA2G7 (Gene name),

Platelet-activating factor acetylhydrolase (Protein name ), PAFA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

PLA2G7(PAFAH);

Protein name:

Platelet-activating factor acetylhydrolase(PAF acetylhydrolase);

Alternative:

2-acetyl-1-alkylglycerophosphocholine esterase;1-alkyl-2-acetylglycerophosphocholine esterase;LDL-associated phospholipase A2(LDL-PLA(2));Group-VIIA phospholipase A2(gVIIA-PLA2);PAF 2-acylhydrolase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

Subcellular Location:

Secreted extracellular space

Protein Attributes:

Sequence length:

441

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

441:

DFDQWDCLIE | GDDENLIPGT | NINTTNQHIM | LQNSSGIEKY | N

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

601690

MIM:

147050

String:

Q13093

UniGene:

Hs.584823

Pfam:

PF03403

SMR:

Q13093

STRING:

9606.ENSP00000274793

KEGG:

hsa:7941

Uniprot:

Q13093

FOR

ELISA Kit for Human PAF acetylhydrolase

Cat.:

E0867h

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Manual:

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Packing:

96T

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ELISA Kit for Human PAF acetylhydrolase

Cat.:

E0867m

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Manual:

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Packing:

96T

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ELISA Kit for Human PAF acetylhydrolase

Cat.:

E0867b

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96T

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ELISA Kit for Human PAF acetylhydrolase

Cat.:

E0867d

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Packing:

96T

ELISA Kit for Human PAF acetylhydrolase

Cat.:

E0867c

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Packing:

96T

CLIA Kit for Human PAF acetylhydrolase

Cat.:

U0867c

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MSDS:

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Packing:

96T

CLIA Kit for Human PAF acetylhydrolase

Cat.:

U0867m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human PAF acetylhydrolase

Cat.:

U0867h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human PAF acetylhydrolase

Cat.:

U0867b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human PAF acetylhydrolase

Cat.:

U0867d

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Packing:

96T

Polyclonal Antibody for Human PAF acetylhydrolase

Cat.:

P0867Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PAF acetylhydrolase

Cat.:

P0867Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PAF acetylhydrolase

Monoclonal Antibody for Human PAF acetylhydrolase

Protein for Human PAF acetylhydrolase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Brain microangiopathy and macroangiopathy share common risk factors and biomarkers"

Bang O Y, Chung J W, Ryoo S, et al.

From:Atherosclerosis

References

1.

"Anti-inflammatory properties of a platelet-activating factor acetylhydrolase."
Tjoelker L.W. , Wilder C. , Eberhardt C. , Stafforini D.M. , Dietsch G. , Schimpf B. , Hooper S. , le Trong H. , Cousens L.S. , Zimmerman G.A. , Yamada Y. , McIntyre T.M. , Prescott S.M. , Gray P.W.
Nature374:549-553(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 42-57
tissue: Myeloid.
2.

"Purification, properties, sequencing, and cloning of a lipoprotein-associated, serine-dependent phospholipase involved in the oxidative modification of low-density lipoproteins."
Tew D.G. , Southan C. , Rice S.Q.J. , Lawrence M.P. , Li H. , Boyd H.F. , Moores K. , Gloger I.S. , Macphee C.H.
Arterioscler. Thromb. Vasc. Biol.16:591-599(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Lymphoma.
3.

SeattleSNPs variation discovery resource
Submitted (2007-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-45; HIS-92; ASN-191; THR-198 AND ALA-379
4.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-379
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-379
tissue: Blood.
7.

"Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad."
Tjoelker L.W. , Eberhardt C. , Unger J. , le Trong H. , Zimmerman G.A. , McIntyre T.M. , Stafforini D.M. , Prescott S.M. , Gray P.W.
J. Biol. Chem.270:25481-25487(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
8.

"Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis."
Samanta U. , Bahnson B.J.
J. Biol. Chem.283:31617-31624(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 47-429 ALONE AND IN COMPLEX WITH PARAOXON;ACTIVE SITE
9.

"Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes."
Samanta U. , Kirby S.D. , Srinivasan P. , Cerasoli D.M. , Bahnson B.J.
Biochem. Pharmacol.78:420-429(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 47-429 IN COMPLEX WITH ORGANOPHOSPHORUS NERVE AGENTS
10.

"Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase."
Stafforini D.M. , Satoh K. , Atkinson D.L. , Tjoelker L.W. , Eberhardt C. , Yoshida H. , Imaizumi T. , Takamatsu S. , Zimmerman G.A. , McIntyre T.M. , Gray P.W. , Prescott S.M.
J. Clin. Invest.97:2784-2791(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
11.

"Loss of activity of plasma platelet-activating factor acetylhydrolase due to a novel Gln281-->Arg mutation."
Yamada Y. , Yokota M.
Biochem. Biophys. Res. Commun.236:772-775(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD ARG-281
12.

"A mutation in plasma platelet-activating factor acetylhydrolase (Val279-->Phe) is a genetic risk factor for stroke."
Hiramoto M. , Yoshida H. , Imaizumi T. , Yoshimizu N. , Satoh K.
Stroke28:2417-2420(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
13.

"Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men."
Yamada Y. , Ichihara S. , Fujimura T. , Yokota M.
Metabolism47:177-181(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
14.

"A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage but not for hypertension."
Yoshida H. , Imaizumi T. , Fujimoto K. , Itaya H. , Hiramoto M. , Yoshimizu N. , Fukushi K. , Satoh K.
Thromb. Haemost.80:372-375(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PAFAD PHE-279
15.

"The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma."
Kruse S. , Mao X.-Q. , Heinzmann A. , Blattmann S. , Roberts M.H. , Braun S. , Gao P.-S. , Forster J. , Kuehr J. , Hopkin J.M. , Shirakawa T. , Deichmann K.A.
Am. J. Hum. Genet.66:1522-1530(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-92; THR-198 AND ALA-379;INVOLVEMENT IN ASTHMA AND ATOPY

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