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Index > Protein center > MTPAP(Gene name) > Human
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  • MTPAP (Gene name),
  • Poly(A) RNA polymerase, mitochondrial (Protein name ),  PAPD1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MTPAP(PAPD1);
    Protein name:
    Poly(A) RNA polymerase, mitochondrial(PAP);
    Alternative:
    Polynucleotide adenylyltransferase;PAP-associated domain-containing protein 1;mtPAP;Terminal uridylyltransferase 1(TUTase 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
    Subcellular Location:
    Cytoplasm Mitochondrion
    Protein Attributes:
    Sequence length:
    582
    Sequence:
    50:
    MAVPGVGLLT | RLNLCARRRT | RVQRPIVRLL | SCPGTVAKDL | RRDEQPSGSV | 
    100:
    ETGFEDKIPK | RRFSEMQNER | REQAQRTVLI | HCPEKISENK | FLKYLSQFGP | 
    150:
    INNHFFYESF | GLYAVVEFCQ | KESIGSLQNG | THTPSTAMET | AIPFRSRFFN | 
    200:
    LKLKNQTSER | SRVRSSNQLP | RSNKQLFELL | CYAESIDDQL | NTLLKEFQLT | 
    250:
    EENTKLRYLT | CSLIEDMAAA | YFPDCIVRPF | GSSVNTFGKL | GCDLDMFLDL | 
    300:
    DETRNLSAHK | ISGNFLMEFQ | VKNVPSERIA | TQKILSVLGE | CLDHFGPGCV | 
    350:
    GVQKILNARC | PLVRFSHQAS | GFQCDLTTNN | RIALTSSELL | YIYGALDSRV | 
    400:
    RALVFSVRCW | ARAHSLTSSI | PGAWITNFSL | TMMVIFFLQR | RSPPILPTLD | 
    450:
    SLKTLADAED | KCVIEGNNCT | FVRDLSRIKP | SQNTETLELL | LKEFFEYFGN | 
    500:
    FAFDKNSINI | RQGREQNKPD | SSPLYIQNPF | ETSLNISKNV | SQSQLQKFVD | 
    550:
    LARESAWILQ | QEDTDRPSIS | SNRPWGLVSL | LLPSAPNRKS | FTKKKSNKFA | 
    582:
    IETVKNLLES | LKGNRTENFT | KTSGKRTIST | QT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PAP
    Cat.:
    E7107h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PAP
    Cat.:
    E7107m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PAP
    Cat.:
    U7107h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PAP
    Cat.:
    U7107m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PAP
    Cat.:
    P7107Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PAP
    Cat.:
    P7107Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PAP
    Monoclonal Antibody for Human PAP
    Protein for Human PAP
    Protein for Human PAP

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase."
      Tomecki R. , Dmochowska A. , Gewartowski K. , Dziembowski A. , Stepien P.P.
      Nucleic Acids Res.32:6001-6014(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Cervix carcinoma.
    2. 2.
      "Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase."
      Nagaike T. , Suzuki T. , Katoh T. , Ueda T.
      J. Biol. Chem.280:19721-19727(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
    3. 3.
      "NovelFam3000 -- uncharacterized human protein domains conserved across model organisms."
      Kemmer D. , Podowski R.M. , Arenillas D. , Lim J. , Hodges E. , Roth P. , Sonnhammer E.L.L. , Hoeoeg C. , Wasserman W.W.
      BMC Genomics7:48-48(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Mammary gland.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS HIS-221; ARG-419 AND ASN-546
    9. 9.
      "Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'."
      Mullen T.E. , Marzluff W.F.
      Genes Dev.22:50-65(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HISTONE MRNA DEGRADATION ACTIVITY;SUBCELLULAR LOCATION
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-90;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase."
      Bai Y. , Srivastava S.K. , Chang J.H. , Manley J.L. , Tong L.
      Mol. Cell41:311-320(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 44-538;FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;COFACTOR;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF 221-TYR-PHE-222; PHE-230; 259-HIS--ILE-261; 294-HIS--PRO-297; LEU-312; ASP-325 AND PHE-378
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SPAX4 ASP-478;CATALYTIC ACTIVITY;FUNCTION
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