PAPPA ELISA Kit for Human(Homo sapiens) | EIAab.comPAPPA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PAPPA(Gene name) > Human

PAPPA (Gene name),

Pappalysin-1 (Protein name ), PAPP1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

PAPPA;

Protein name:

Pappalysin-1;

Alternative:

Pregnancy-associated plasma protein A(PAPP-A);Insulin-like growth factor-dependent IGF-binding protein 4 protease(IGF-dependent IGFBP-4 protease;IGFBP-4ase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.

Function:

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

1627

Sequence:

50:

100:

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1627:

DLQGDCACRD | PQAQEHSRKD | LRGYSHG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q13219

STRING:

9606.ENSP00000330658

SMR:

Q13219

Pfam:

PF00066

UniGene:

Hs.643599

KEGG:

hsa:5069

MIM:

176385

Uniprot:

Q13219

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ELISA Kit for Human Pappalysin-1

Cat.:

E0800m

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Manual:

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Packing:

96T

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ELISA Kit for Human Pappalysin-1

Cat.:

E0800h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Pappalysin-1

Cat.:

U0800h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Pappalysin-1

Cat.:

U0800m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Pappalysin-1

Cat.:

P0800Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Pappalysin-1

Cat.:

P0800Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Pappalysin-1

Protein for Human Pappalysin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Genetic relationship between serum pregnancy-associated plasma protein-A gene polymorphism and ischemic cerebrovascular disease in a Northern Han..."

H Wang, Y Song, C Zhang, et al.

From:中国神经再生研究 (英文版)

References

1.

"Complete cDNA sequence of the preproform of human pregnancy-associated plasma protein-A. Evidence for expression in the brain and induction by cAMP."
Haaning J. , Oxvig C. , Overgaard M.T. , Ebbesen P. , Kristensen T. , Sottrup-Jensen L.
Eur. J. Biochem.237:159-163(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;VARIANT ARG-944
tissue: Placenta.
2.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT TYR-1224
tissue: Placenta.
4.

"Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA."
Kristensen T. , Oxvig C. , Sand O. , Moller N.P.H. , Sottrup-Jensen L.
Biochemistry33:1592-1598(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-1627;PROTEIN SEQUENCE OF 81-98; 117-126; 210-224; 466-485; 507-519; 576-593; 609-621; 718-736; 742-754; 1006-1017; 1259-1273; 1369-1374; 1389-1398; 1490-1509; 1524-1533 AND 1537-1544;VARIANT ARG-944;TISSUE SPECIFICITY
tissue: Placenta.
tissue: Serum.
5.

"Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein."
Oxvig C. , Sand O. , Kristensen T. , Gleich G.J. , Sottrup-Jensen L.
J. Biol. Chem.268:12243-12246(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 81-89; 117-126; 210-224; 460-485; 507-519; 576-593; 718-736; 742-754; 1259-1273; 1369-1374; 1490-1509; 1524-1533 AND 1537-1544;SUBUNIT;INTERCHAIN DISULFIDE BOND
tissue: Serum.
6.

"Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."
Overgaard M.T. , Sorensen E.S. , Stachowiak D. , Boldt H.B. , Kristensen L. , Sottrup-Jensen L. , Oxvig C.
J. Biol. Chem.278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-402; ASN-429; ASN-480; ASN-601; ASN-619; ASN-725; ASN-1026; ASN-1226; ASN-1323 AND ASN-1519;DISULFIDE BONDS
7.

"The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A."
Lawrence J.B. , Oxvig C. , Overgaard M.T. , Sottrup-Jensen L. , Gleich G.J. , Hays L.G. , Yates J.R. III , Conover C.A.
Proc. Natl. Acad. Sci. U.S.A.96:3149-3153(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Fibroblast.
8.

"Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."
Overgaard M.T. , Haaning J. , Boldt H.B. , Olsen I.M. , Laursen L.S. , Christiansen M. , Gleich G.J. , Sottrup-Jensen L. , Conover C.A. , Oxvig C.
J. Biol. Chem.275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;ENZYME REGULATION
9.

"Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta."
Bonno M. , Oxvig C. , Kephart G.M. , Wagner J.M. , Kristensen T. , Sottrup-Jensen L. , Gleich G.J.
Lab. Invest.71:560-566(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues."
Overgaard M.T. , Oxvig C. , Christiansen M. , Lawrence J.B. , Conover C.A. , Gleich G.J. , Sottrup-Jensen L. , Haaning J.
Biol. Reprod.61:1083-1089(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
11.

"Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
Oxvig C. , Haaning J. , Kristensen L. , Wagner J.M. , Rubin I. , Stigbrand T. , Gleich G.J. , Sottrup-Jensen L.
J. Biol. Chem.270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
12.

"Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A."
Laursen L.S. , Overgaard M.T. , Soe R. , Boldt H.B. , Sottrup-Jensen L. , Giudice L.C. , Conover C.A. , Oxvig C.
FEBS Lett.504:36-40(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene."
Frosk P. , Weiler T. , Nylen E. , Sudha T. , Greenberg C.R. , Morgan K. , Fujiwara T.M. , Wrogemann K.
Am. J. Hum. Genet.70:663-672(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-1224

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