F2R ELISA Kit for Human(Homo sapiens) | EIAab.comF2R ELISA Kit for Human(Homo sapiens) | EIAab.com

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F2R (Gene name),

Proteinase-activated receptor 1 (Protein name ), PAR1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Citations (2)

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Gene name:

F2R(CF2R;PAR1;TR);

Protein name:

Proteinase-activated receptor 1(PAR-1);

Alternative:

Thrombin receptor;Coagulation factor II receptor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

425

Sequence:

50:

MGPRRLLLVA | ACFSLCGPLL | SARTRARRPE | SKATNATLDP | RSFLLRNPND |

100:

KYEPFWEDEE | KNESGLTEYR | LVSINKSSPL | QKQLPAFISE | DASGYLTSSW |

150:

LTLFVPSVYT | GVFVVSLPLN | IMAIVVFILK | MKVKKPAVVY | MLHLATADVL |

200:

FVSVLPFKIS | YYFSGSDWQF | GSELCRFVTA | AFYCNMYASI | LLMTVISIDR |

250:

FLAVVYPMQS | LSWRTLGRAS | FTCLAIWALA | IAGVVPLLLK | EQTIQVPGLN |

300:

ITTCHDVLNE | TLLEGYYAYY | FSAFSAVFFF | VPLIISTVCY | VSIIRCLSSS |

350:

AVANRSKKSR | ALFLSAAVFC | IFIICFGPTN | VLLIAHYSFL | SHTSTTEAAY |

400:

FAYLLCVCVS | SISCCIDPLI | YYYASSECQR | YVYSILCCKE | SSDPSSYNSS |

425:

GQLMASKMDT | CSSNLNNSIY | KKLLT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

STRING:

9606.ENSP00000321326

Pfam:

SMR:

UniGene:

String:

KEGG:

Uniprot:

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ELISA Kit for Human PAR-1

Cat.:

E0826m

Price:

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MSDS:

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Packing:

96T

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ELISA Kit for Human PAR-1

Cat.:

E0826h

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Packing:

96T

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ELISA Kit for Human PAR-1

Cat.:

E0826r

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96T

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ELISA Kit for Human PAR-1

Cat.:

E0826b

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96T

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CLIA Kit for Human PAR-1

Cat.:

U0826r

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Looking for manual.

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96T

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CLIA Kit for Human PAR-1

Cat.:

U0826h

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Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Human PAR-1

Cat.:

U0826m

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human PAR-1

Cat.:

U0826b

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human PAR-1

Cat.:

P0826Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PAR-1

Polyclonal Antibody for Human PAR-1

Cat.:

P0826Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PAR-1

Cat.:

P0826Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PAR-1

Monoclonal Antibody for Human PAR-1

Monoclonal Antibody for Human PAR-1

Monoclonal Antibody for Human PAR-1

Protein for Human PAR-1

Protein for Human PAR-1

Protein for Human PAR-1

Protein for Human PAR-1

R&D Technical Data

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s

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s

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Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤7.5%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤12.1%

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

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Recovery

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Recovery was determined by spiking various levels of PAR1 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	96	93-100
Plasma	97	91-103

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of PAR1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	93-98%	93-100%	94-100%	92-101%
EDTA plasma(n=5)	91-100%	94-99%	90-102%	93-99%
heparin plasma(n=5)	92-99%	91-102%	91-101%	93-100%

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

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Citations

[1].

"Clinical significance of serum protease-activated receptor-1 levels in gastric cancer patients"

Tas F, Karabulut S, Tastekin D, et al.

From:Biomedical reports

[2].

"Clinical significance of serum Protease-Activated Receptor-1 (PAR-1) levels in patients with cutaneous melanoma"

Tas F, Bilgin E, Karabulut S, et al.

From:BBA clinical

References

1.

"Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation."
Vu T.-K.H. , Hung D.T. , Wheaton V.I. , Coughlin S.R.
Cell64:1057-1068(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

SeattleSNPs variation discovery resource
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-335
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-335
tissue: Eye.
5.

"Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization."
Shapiro M.J. , Trejo J. , Zeng D. , Coughlin S.R.
J. Biol. Chem.271:32874-32880(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
6.

"Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin."
Kahn M.L. , Nakanishi-Matsui M. , Shapiro M.J. , Ishihara H. , Coughlin S.R.
J. Clin. Invest.103:879-887(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis."
Zania P. , Gourni D. , Aplin A.C. , Nicosia R.F. , Flordellis C.S. , Maragoudakis M.E. , Tsopanoglou N.E.
J. Pharmacol. Exp. Ther.328:378-389(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ANGIOGENESIS INHIBITION PROPERTIES OF PARSTATIN
8.

"The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression."
Zampatis D.E. , Rutz C. , Furkert J. , Schmidt A. , Wustenhagen D. , Kubick S. , Tsopanoglou N.E. , Schulein R.
FEBS Lett.586:2351-2359(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIGNAL SEQUENCE CLEAVAGE SITE
9.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-166
10.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
11.

"Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes."
Mathews I.I. , Padmanabhan K.P. , Ganesh V. , Tulinsky A. , Ishii M. , Chen J. , Turck C.W. , Coughlin S.R. , Fenton J.W. II
Biochemistry33:3266-3279(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 38-64 IN COMPLEX WITH THROMBIN

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