Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > F2RL1(Gene name) > Human
  • Add your favorite
  • F2RL1 (Gene name),
  • Proteinase-activated receptor 2 (Protein name ),  PAR2_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    F2RL1(GPR11;PAR2);
    Protein name:
    Proteinase-activated receptor 2(PAR-2);
    Alternative:
    G-protein coupled receptor 11;Coagulation factor II receptor-like 1;Thrombin receptor-like 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14.
    Function:
    Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilatation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    397
    Sequence:
    50:
    MRSPSAAWLL | GAAILLAASL | SCSGTIQGTN | RSSKGRSLIG | KVDGTSHVTG | 
    100:
    KGVTVETVFS | VDEFSASVLT | GKLTTVFLPI | VYTIVFVVGL | PSNGMALWVF | 
    150:
    LFRTKKKHPA | VIYMANLALA | DLLSVIWFPL | KIAYHIHGNN | WIYGEALCNV | 
    200:
    LIGFFYGNMY | CSILFMTCLS | VQRYWVIVNP | MGHSRKKANI | AIGISLAIWL | 
    250:
    LILLVTIPLY | VVKQTIFIPA | LNITTCHDVL | PEQLLVGDMF | NYFLSLAIGV | 
    300:
    FLFPAFLTAS | AYVLMIRMLR | SSAMDENSEK | KRKRAIKLIV | TVLAMYLICF | 
    350:
    TPSNLLLVVH | YFLIKSQGQS | HVYALYIVAL | CLSTLNSCID | PFVYYFVSHD | 
    397:
    FRDHAKNALL | CRSVRTVKQM | QVSLTSKKHS | RKSSSYSSSS | TTVKTSY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human PAR-2
    Cat.:
    E2022h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PAR-2
    Cat.:
    E2022b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PAR-2
    Cat.:
    E2022m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PAR-2
    Cat.:
    E2022r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PAR-2
    Cat.:
    U2022r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PAR-2
    Cat.:
    U2022m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PAR-2
    Cat.:
    U2022h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PAR-2
    Cat.:
    U2022b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PAR-2
    Cat.:
    P2022Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PAR-2
    Polyclonal Antibody for Human PAR-2
    Cat.:
    P2022Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PAR-2
    Cat.:
    P2022Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PAR-2
    Monoclonal Antibody for Human PAR-2
    Monoclonal Antibody for Human PAR-2
    Monoclonal Antibody for Human PAR-2
    Protein for Human PAR-2
    Protein for Human PAR-2
    Protein for Human PAR-2
    Protein for Human PAR-2

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2."
      Nystedt S. , Emilsson K. , Larsson A.-K. , Stroembeck B. , Sundelin J.
      Eur. J. Biochem.232:84-89(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2."
      Boehm S.K. , Kong W. , Broemme D. , Smeekens S.P. , Anderson D.C. , Connolly A.J. , Kahn M.L. , Nelken N.A. , Coughlin S.R. , Payan D.G. , Bunnett N.W.
      Biochem. J.314:1009-1016(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Kidney.
    3. 3.
      "Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1."
      Luo W. , Wang Y. , Hanck T. , Stricker R. , Reiser G.
      J. Biol. Chem.281:7927-7936(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH COPS5
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PHE-21; GLN-270 AND ALA-291
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
      tissue: Pancreas.
    8. 8.
      "Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster."
      Kahn M.L. , Ishii K. , Kuo W.L. , Piper M. , Connolly A.J. , Shi Y.P. , Wu R. , Lin C.C. , Coughlin S.R.
      Mol. Med.2:349-357(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-397
    9. 9.
      "Interactions of mast cell tryptase with thrombin receptors and PAR-2."
      Molino M. , Barnathan E.S. , Numerof R. , Clark J. , Dreyer M. , Cumashi A. , Hoxie J.A. , Schechter N. , Woolkalis M. , Brass L.F.
      J. Biol. Chem.272:4043-4049(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVATION BY MAST CELL TRYPTASE
    10. 10.
      "A protective role for protease-activated receptors in the airways."
      Cocks T.M. , Fong B. , Chow J.M. , Anderson G.P. , Frauman A.G. , Goldie R.G. , Henry P.J. , Carr M.J. , Hamilton J.R. , Moffatt J.D.
      Nature398:156-160(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN EPITHELIAL BARRIER PROTECTION
    11. 11.
      "Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1."
      O'Brien P.J. , Prevost N. , Molino M. , Hollinger M.K. , Woolkalis M.J. , Woulfe D.S. , Brass L.F.
      J. Biol. Chem.275:13502-13509(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSACTIVATION BY F2R
    12. 12.
      "beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2."
      DeFea K.A. , Zalevsky J. , Thoma M.S. , Dery O. , Mullins R.D. , Bunnett N.W.
      J. Cell Biol.148:1267-1281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-363 AND THR-366
    13. 13.
      "Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates."
      Takeuchi T. , Harris J.L. , Huang W. , Yan K.W. , Coughlin S.R. , Craik C.S.
      J. Biol. Chem.275:26333-26342(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVATION BY ST14
    14. 14.
      "Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa."
      Camerer E. , Huang W. , Coughlin S.R.
      Proc. Natl. Acad. Sci. U.S.A.97:5255-5260(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVATION BY COAGULATION FACTORS VII AND XA
    15. 15.
      "Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion."
      Lourbakos A. , Potempa J. , Travis J. , D'Andrea M.R. , Andrade-Gordon P. , Santulli R. , Mackie E.J. , Pike R.N.
      Infect. Immun.69:5121-5130(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVATION BY GINGIPAINS
    16. 16.
      "Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes."
      Kanke T. , Macfarlane S.R. , Seatter M.J. , Davenport E. , Paul A. , McKenzie R.C. , Plevin R.
      J. Biol. Chem.276:31657-31666(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN JNK AND NF-KAPPA-B PATHWAYS
    17. 17.
      "Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells."
      Sun G. , Stacey M.A. , Schmidt M. , Mori L. , Mattoli S.
      J. Immunol.167:1014-1021(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVATION BY DUST MITE ALLERGENS
    18. 18.
      "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2."
      Miike S. , McWilliam A.S. , Kita H.
      J. Immunol.167:6615-6622(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INFLAMMATORY RESPONSE
    19. 19.
      "Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling."
      Compton S.J. , Sandhu S. , Wijesuriya S.J. , Hollenberg M.D.
      Biochem. J.368:495-505(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-30 AND ASN-222;MUTAGENESIS OF ASN-30 AND ASN-222
    20. 20.
      "Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear."
      Kawagoe J. , Takizawa T. , Matsumoto J. , Tamiya M. , Meek S.E. , Smith A.J. , Hunter G.D. , Plevin R. , Saito N. , Kanke T. , Fujii M. , Wada Y.
      Jpn. J. Pharmacol.88:77-84(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN ALLERGIC DERMATITIS
    21. 21.
      "Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases."
      Dulon S. , Cande C. , Bunnett N.W. , Hollenberg M.D. , Chignard M. , Pidard D.
      Am. J. Respir. Cell Mol. Biol.28:339-346(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEACTIVATION BY NEUTROPHIL ELASTASE AND CATHEPSIN G
    22. 22.
      "Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo."
      Seeliger S. , Derian C.K. , Vergnolle N. , Bunnett N.W. , Nawroth R. , Schmelz M. , Von Der Weid P.Y. , Buddenkotte J. , Sunderkotter C. , Metze D. , Andrade-Gordon P. , Harms E. , Vestweber D. , Luger T.A. , Steinhoff M.
      FASEB J.17:1871-1885(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN SKIN DISEASES
    23. 23.
      "Expression of and functional responses to protease-activated receptors on human eosinophils."
      Bolton S.J. , McNulty C.A. , Thomas R.J. , Hewitt C.R. , Wardlaw A.J.
      J. Leukoc. Biol.74:60-68(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    24. 24.
      "The role of the C-terminal tail in protease-activated receptor-2-mediated Ca2+ signalling, proline-rich tyrosine kinase-2 activation, and mitogen-activated protein kinase activity."
      Seatter M.J. , Drummond R. , Kanke T. , Macfarlane S.R. , Hollenberg M.D. , Plevin R.
      Cell. Signal.16:21-29(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 355-ALA--SER-363
    25. 25.
      "Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices."
      Shpacovitch V.M. , Varga G. , Strey A. , Gunzer M. , Mooren F. , Buddenkotte J. , Vergnolle N. , Sommerhoff C.P. , Grabbe S. , Gerke V. , Homey B. , Hollenberg M. , Luger T.A. , Steinhoff M.
      J. Leukoc. Biol.76:388-398(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    26. 26.
      "c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2."
      Jacob C. , Cottrell G.S. , Gehringer D. , Schmidlin F. , Grady E.F. , Bunnett N.W.
      J. Biol. Chem.280:16076-16087(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY CBL
    27. 27.
      "Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling."
      Feistritzer C. , Lenta R. , Riewald M.
      J. Thromb. Haemost.3:2798-2805(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOTHELIAL BARRIER PROTECTION
    28. 28.
      "A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis."
      Hansen K.K. , Sherman P.M. , Cellars L. , Andrade-Gordon P. , Pan Z. , Baruch A. , Wallace J.L. , Hollenberg M.D. , Vergnolle N.
      Proc. Natl. Acad. Sci. U.S.A.102:8363-8368(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN COLITIS
    29. 29.
      "Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice."
      Takizawa T. , Tamiya M. , Hara T. , Matsumoto J. , Saito N. , Kanke T. , Kawagoe J. , Hattori Y.
      J. Pharmacol. Sci.98:99-102(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN BRONCHIAL EOSINOPHILIC INFLAMMATION
    30. 30.
      "PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of beta-agonists."
      Winter M.C. , Shasby S.S. , Ries D.R. , Shasby D.M.
      Am. J. Physiol.291:L628-L635(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN EPITHELIAL BARRIER DISRUPTION
    31. 31.
      "Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway."
      Csernok E. , Ai M. , Gross W.L. , Wicklein D. , Petersen A. , Lindner B. , Lamprecht P. , Holle J.U. , Hellmich B.
      Blood107:4440-4448(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVATION BY PRTN3
    32. 32.
      "Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis."
      Noorbakhsh F. , Tsutsui S. , Vergnolle N. , Boven L.A. , Shariat N. , Vodjgani M. , Warren K.G. , Andrade-Gordon P. , Hollenberg M.D. , Power C.
      J. Exp. Med.203:425-435(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN ENCEPHALOMYELITIS AND MULTIPLE SCLEROSIS
    33. 33.
      "Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2."
      Zoudilova M. , Kumar P. , Ge L. , Wang P. , Bokoch G.M. , DeFea K.A.
      J. Biol. Chem.282:20634-20646(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIN FILAMENT SEVERING
    34. 34.
      "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking."
      Luo W. , Wang Y. , Reiser G.
      J. Biol. Chem.282:30246-30255(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMED2
    35. 35.
      "Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2."
      Chiu L.L. , Perng D.W. , Yu C.H. , Su S.N. , Chow L.P.
      J. Immunol.178:5237-5244(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVATION BY MOLD ALLERGENS
    36. 36.
      "Chitinase activates protease-activated receptor-2 in human airway epithelial cells."
      Hong J.H. , Hong J.Y. , Park B. , Lee S.I. , Seo J.T. , Kim K.E. , Sohn M.H. , Shin D.M.
      Am. J. Respir. Cell Mol. Biol.39:530-535(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVATION BY BACTERIAL CHITINASE
    37. 37.
      "G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFkappaB serine 536 phosphorylation in human keratinocytes."
      Goon Goh F. , Sloss C.M. , Cunningham M.R. , Nilsson M. , Cadalbert L. , Plevin R.
      Cell. Signal.20:1267-1274(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    38. 38.
      "Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity."
      Rallabhandi P. , Nhu Q.M. , Toshchakov V.Y. , Piao W. , Medvedev A.E. , Hollenberg M.D. , Fasano A. , Vogel S.N.
      J. Biol. Chem.283:24314-24325(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TLR4
    39. 39.
      "Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection."
      Feld M. , Shpacovitch V.M. , Ehrhardt C. , Kerkhoff C. , Hollenberg M.D. , Vergnolle N. , Ludwig S. , Steinhoff M.
      J. Immunol.180:6903-6910(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANTIVIRAL RESPONSE
    40. 40.
      "Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2."
      Hasdemir B. , Murphy J.E. , Cottrell G.S. , Bunnett N.W.
      J. Biol. Chem.284:28453-28466(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEUBIQUITINATION
    41. 41.
      "Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization."
      Ricks T.K. , Trejo J.
      J. Biol. Chem.284:34444-34457(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    42. 42.
      "Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway."
      Khoufache K. , LeBouder F. , Morello E. , Laurent F. , Riffault S. , Andrade-Gordon P. , Boullier S. , Rousset P. , Vergnolle N. , Riteau B.
      J. Immunol.182:7795-7802(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANTIVIRAL RESPONSE
    43. 43.
      "Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils."
      Matsuwaki Y. , Wada K. , White T.A. , Benson L.M. , Charlesworth M.C. , Checkel J.L. , Inoue Y. , Hotta K. , Ponikau J.U. , Lawrence C.B. , Kita H.
      J. Immunol.183:6708-6716(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIVATION BY TRYPSIN AND FUNGAL ASPARTATE PROTEASE
    44. 44.
      "Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis."
      Ferrell W.R. , Kelso E.B. , Lockhart J.C. , Plevin R. , McInnes I.B.
      Ann. Rheum. Dis.69:2051-2054(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN ARTHRITIS
    45. 45.
      "Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - a novel paradigm for G(q/11) linked GPCRs."
      McIntosh K. , Cunningham M.R. , Cadalbert L. , Lockhart J. , Boyd G. , Ferrell W.R. , Plevin R.
      Cell. Signal.22:265-273(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN JNK PATHWAY
    46. 46.
      "Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1."
      Bae J.S. , Yang L. , Rezaie A.R.
      J. Biol. Chem.285:34803-34812(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOTHELIAL BARRIER PROTECTION
    47. 47.
      "Protease-activated receptor-2 (PAR(2)) in human periodontitis."
      Holzhausen M. , Cortelli J.R. , da Silva V.A. , Franco G.C. , Cortelli S.C. , Vergnolle N.
      J. Dent. Res.89:948-953(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN PERIODONTITIS
    48. 48.
      "Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo."
      Nhu Q.M. , Shirey K. , Teijaro J.R. , Farber D.L. , Netzel-Arnett S. , Antalis T.M. , Fasano A. , Vogel S.N.
      Mucosal Immunol.3:29-39(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    49. 49.
      "Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-gamma on human neutrophils and monocytes."
      Shpacovitch V.M. , Feld M. , Holzinger D. , Kido M. , Hollenberg M.D. , Levi-Schaffer F. , Vergnolle N. , Ludwig S. , Roth J. , Luger T. , Steinhoff M.
      Immunology133:329-339(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANTIMICROBIAL RESPONSE
    50. 50.
      "Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor triggered ERK1/2 activation, calcium signalling, and endocytosis."
      Botham A. , Guo X. , Xiao Y.P. , Morice A.H. , Compton S.J. , Sadofsky L.R.
      Biochem. J.438:359-367(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-361
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter