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Index > Protein center > PXN(Gene name) > Human
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  • PXN (Gene name),
  • Paxillin (Protein name ),  PAXI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PXN;
    Protein name:
    Paxillin;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Interacts with PTK2 (By similarity). Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5 and PDCD10. Interacts with NEK3 and this interaction is prolactin-dependent.
    Function:
    Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
    Subcellular Location:
    Cytoplasm cytoskeleton Cell junction focal adhesion
    Protein Attributes:
    Sequence length:
    591
    Sequence:
    50:
    MDDLDALLAD | LESTTSHISK | RPVFLSEETP | YSYPTGNHTY | QEIAVPPPVP | 
    100:
    PPPSSEALNG | TILDPLDQWQ | PSSSRFIHQQ | PQSSSPVYGS | SAKTSSVSNP | 
    150:
    QDSVGSPCSR | VGEEEHVYSF | PNKQKSAEPS | PTVMSTSLGS | NLSELDRLLL | 
    200:
    ELNAVQHNPP | GFPADEANSS | PPLPGALSPL | YGVPETNSPL | GGKAGPLTKE | 
    250:
    KPKRNGGRGL | EDVRPSVESL | LDELESSVPS | PVPAITVNQG | EMSSPQRVTS | 
    300:
    TQQQTRISAS | SATRELDELM | ASLSDFKIQG | LEQRADGERC | WAAGWPRDGG | 
    350:
    RSSPGGQDEG | GFMAQGKTGS | SSPPGGPPKP | GSQLDSMLGS | LQSDLNKLGV | 
    400:
    ATVAKGVCGA | CKKPIAGQVV | TAMGKTWHPE | HFVCTHCQEE | IGSRNFFERD | 
    450:
    GQPYCEKDYH | NLFSPRCYYC | NGPILDKVVT | ALDRTWHPEH | FFCAQCGAFF | 
    500:
    GPEGFHEKDG | KAYCRKDYFD | MFAPKCGGCA | RAILENYISA | LNTLWHPECF | 
    550:
    VCRECFTPFV | NGSFFEHDGQ | PYCEVHYHER | RGSLCSGCQK | PITGRCITAM | 
    591:
    AKKFHPEHFV | CAFCLKQLNK | GTFKEQNDKP | YCQNCFLKLF | C
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    MIM:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Paxillin
    Cat.:
    E1844c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Paxillin
    Cat.:
    E1844h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Paxillin
    Cat.:
    E1844m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Paxillin
    Cat.:
    E1844r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Paxillin
    Cat.:
    U1844c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Paxillin
    Cat.:
    U1844h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Paxillin
    Cat.:
    U1844r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Paxillin
    Cat.:
    U1844m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Paxillin
    Polyclonal Antibody for Human Paxillin
    Cat.:
    P1844Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Paxillin
    Cat.:
    P1844Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Paxillin
    Cat.:
    P1844Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Paxillin
    Monoclonal Antibody for Human Paxillin
    Monoclonal Antibody for Human Paxillin
    Monoclonal Antibody for Human Paxillin
    Protein for Human Paxillin
    Protein for Human Paxillin
    Protein for Human Paxillin
    Protein for Human Paxillin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL."
      Salgia R. , Li J.-L. , Lo S.H. , Brunkhorst B. , Kansas G.S. , Sobhany E.S. , Sun Y. , Pisick E. , Hallek M. , Ernst T. , Tantravahi R. , Chen L.B. , Griffin J.D.
      J. Biol. Chem.270:5039-5047(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA);VARIANT GLY-73
    2. 2.
      "Transcription map of the 5cM region surrounding the hepatocyte nuclear factor-1a/MODY3 gene on chromosome 12."
      Yamagata K. , Oda N. , Furuta H. , Vaxillaire M. , Southam L. , Boriraj V. , Chen X. , Oda Y. , Takeda J. , Yamada S. , Nishigori H. , Lebeau M.M. , Lathrop M. , Cox R.D. , Bell G.I.
      Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-73
    3. 3.
      "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins."
      Mazaki Y. , Hashimoto S. , Sabe H.
      J. Biol. Chem.272:7437-7444(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA AND GAMMA);VARIANT GLY-73
      tissue: Placenta.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT GLY-73
      tissue: Placenta.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Fetal kidney.
    6. 6.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT GLY-73
      tissue: Brain.
      tissue: Testis.
    8. 8.
      "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses."
      Liu S. , Thomas S.M. , Woodside D.G. , Rose D.M. , Kiosses W.B. , Pfaff M. , Ginsberg M.H.
      Nature402:676-681(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGA4
    9. 9.
      "Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly."
      Zhao Z.-S. , Manser E. , Loo T.-H. , Lim L.
      Mol. Cell. Biol.20:6354-6363(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GIT1
    10. 10.
      "A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration."
      Kondo A. , Hashimoto S. , Yano H. , Nagayama K. , Mazaki Y. , Sabe H.
      Mol. Biol. Cell11:1315-1327(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ASAP2
    11. 11.
      "Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration."
      Iwasaki T. , Nakata A. , Mukai M. , Shinkai K. , Yano H. , Sabe H. , Schaefer E. , Tatsuta M. , Tsujimura T. , Terada N. , Kakishita E. , Akedo H.
      Int. J. Cancer97:330-335(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-31; TYR-118 AND TYR-181
    12. 12.
      "RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization."
      Didier C. , Broday L. , Bhoumik A. , Israeli S. , Takahashi S. , Nakayama K. , Thomas S.M. , Turner C.E. , Henderson S. , Sabe H. , Ronai Z.
      Mol. Cell. Biol.23:5331-5345(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF5
    13. 13.
      "Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin."
      Chen H.Y. , Shen C.H. , Tsai Y.T. , Lin F.C. , Huang Y.P. , Chen R.H.
      Mol. Cell. Biol.24:10558-10572(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-31 AND TYR-118;INTERACTION WITH PTK6
    14. 14.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin."
      Miyamoto Y. , Yamauchi J. , Chan J.R. , Okada A. , Tomooka Y. , Hisanaga S. , Tanoue A.
      J. Cell Sci.120:4355-4366(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-244
    17. 17.
      "Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells."
      Miller S.L. , Antico G. , Raghunath P.N. , Tomaszewski J.E. , Clevenger C.V.
      Oncogene26:4668-4678(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEK3
    18. 18.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-106; SER-126; SER-130; SER-137 AND SER-322;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85 AND SER-126;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    24. 24.
      "Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity."
      Li X. , Zhang R. , Zhang H. , He Y. , Ji W. , Min W. , Boggon T.J.
      J. Biol. Chem.285:24099-24107(2010) [PubMed] [Europe PMC] [Abstract]
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      Nat. Immunol.11:155-161(2010) [PubMed] [Europe PMC] [Abstract]
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      Lorenz S. , Vakonakis I. , Lowe E.D. , Campbell I.D. , Noble M.E. , Hoellerer M.K.
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