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Index > Protein center > PCGF6(Gene name) > Human
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  • PCGF6 (Gene name),
  • Polycomb group RING finger protein 6 (Protein name ),  PCGF6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    PCGF6(MBLR;RNF134);
    Protein name:
    Polycomb group RING finger protein 6;
    Alternative:
    RING finger protein 134;Mel18 and Bmi1-like RING finger;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of a PRC1-like complex. Interacts with BMI1/PCGF4, RING1 and RNF2. Interacts with KDM5D. Interacts with CBX4, CBX6, CBX7 and CBX8.
    Function:
    Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    350
    Sequence:
    50:
    MEGVAVVTAG | SVGAAKTEGA | AALPPPPPVS | PPALTPAPAA | GEEGPAPLSE | 
    100:
    TGAPGCSGSR | PPELEPERSL | GRFRGRFEDE | DEELEEEEEL | EEEEEEEEED | 
    150:
    MSHFSLRLEG | GRQDSEDEEE | RLINLSELTP | YILCSICKGY | LIDATTITEC | 
    200:
    LHTFCKSCIV | RHFYYSNRCP | KCNIVVHQTQ | PLYNIRLDRQ | LQDIVYKLVI | 
    250:
    NLEEREKKQM | HDFYKERGLE | VPKPAVPQPV | PSSKGRSKKV | LESVFRIPPE | 
    300:
    LDMSLLLEFI | GANEGTGHFK | PLEKKFVRVS | GEATIGHVEK | FLRRKMGLDP | 
    350:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Polycomb group RING finger protein 6
    Cat.:
    E12055m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Polycomb group RING finger protein 6
    Cat.:
    E12055r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Polycomb group RING finger protein 6
    Cat.:
    E12055h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Polycomb group RING finger protein 6
    Cat.:
    U12055m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Polycomb group RING finger protein 6
    Cat.:
    U12055r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Polycomb group RING finger protein 6
    Cat.:
    U12055h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Polycomb group RING finger protein 6
    Cat.:
    P12055Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Polycomb group RING finger protein 6
    Polyclonal Antibody for Human Polycomb group RING finger protein 6
    Monoclonal Antibody for Human Polycomb group RING finger protein 6
    Monoclonal Antibody for Human Polycomb group RING finger protein 6
    Monoclonal Antibody for Human Polycomb group RING finger protein 6
    Protein for Human Polycomb group RING finger protein 6
    Protein for Human Polycomb group RING finger protein 6
    Protein for Human Polycomb group RING finger protein 6

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    Precision
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    Linearity
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    References
    1. 1.
      "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation."
      Akasaka T. , Takahashi N. , Suzuki M. , Koseki H. , Bodmer R. , Koga H.
      Genes Cells7:835-850(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION IN TRANSCRIPTIONAL REPRESSION;INTERACTION WITH BMI1; RING1 AND RNF2;PHOSPHORYLATION AT SER-30;MUTAGENESIS OF SER-30; SER-57; SER-59 AND SER-69;VARIANT PRO-PRO-23 INS;SUBCELLULAR LOCATION
      tissue: Testis.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANT PRO-PRO-23 INS
      tissue: Cervix.
      tissue: Eye.
    5. 5.
      "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein."
      Lee M.G. , Norman J. , Shilatifard A. , Shiekhattar R.
      Cell128:877-887(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH KDM5D;IDENTIFICATION BY MASS SPECTROMETRY
    6. 6.
      "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."
      Maertens G.N. , El Messaoudi-Aubert S. , Racek T. , Stock J.K. , Nicholls J. , Rodriguez-Niedenfuhr M. , Gil J. , Peters G.
      PLoS ONE4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX
    7. 7.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
      Vandamme J. , Volkel P. , Rosnoblet C. , Le Faou P. , Angrand P.O.
      Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX;INTERACTION WITH CBX4; CBX6; CBX7 AND CBX8;SUBCELLULAR LOCATION
    9. 9.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Solution structure of the RING domain of the human polycomb group RING finger protein 6."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-03) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 124-182
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