Pcna ELISA Kit for Mouse(Mus musculus) | EIAab.comPcna ELISA Kit for Mouse(Mus musculus)

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Pcna (Gene name),

Proliferating cell nuclear antigen (Protein name ), PCNA_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pcna;

Protein name:

Proliferating cell nuclear antigen(PCNA);

Alternative:

Cyclin;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5, FEN1, CDC6, POLD1, POLD3, POLD4 and POLDIP2. Interacts with EXO1, KCTD10 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH (By similarity). Interacts with PPP1R15A. Interacts with HHV-1 ICP34.5. Interacts with NUDT15 (By similarity). Interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Interacts with DDX11.

Function:

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities (By similarity). Has to be loaded onto DNA in order to be able to stimulate APEX2.

Subcellular Location:

Nucleus Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Protein Attributes:

Sequence length:

261

Sequence:

50:

100:

150:

200:

250:

261:

LAPKIEDEEA | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF02747

KEGG:

mmu:18538

UniGene:

Mm.7141

SMR:

P17918

String:

P17918

Uniprot:

P17918

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ELISA Kit for Mouse PCNA

Cat.:

E0591m

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96T

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ELISA Kit for Mouse PCNA

Cat.:

E0591h

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96T

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ELISA Kit for Mouse PCNA

Cat.:

E0591r

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ELISA Kit for Mouse PCNA

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E0591b

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96T

ELISA Kit for Mouse PCNA

Cat.:

E0591c

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96T

CLIA Kit for Mouse PCNA

Cat.:

U0591c

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96T

CLIA Kit for Mouse PCNA

Cat.:

U0591h

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96T

CLIA Kit for Mouse PCNA

Cat.:

U0591b

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96T

CLIA Kit for Mouse PCNA

Cat.:

U0591m

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Packing:

96T

CLIA Kit for Mouse PCNA

Cat.:

U0591r

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96T

Polyclonal Antibody for Mouse PCNA

Cat.:

P0591Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse PCNA

Cat.:

P0591Rb-m

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Polyclonal Antibody for Mouse PCNA

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P0591Rb-r

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Monoclonal Antibody for Mouse PCNA

Protein for Mouse PCNA

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Nucleotide sequence of murine PCNA: interspecies comparison of the cDNA and the 5' flanking region of the gene."
Shipman-Appasamy P.M. , Cohen K.S. , Prystowsky M.B.
DNA Seq.2:181-191(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Lymphoid tissue.
2.

"Molecular cloning and structural analysis of mouse gene and pseudogenes for proliferating cell nuclear antigen."
Yamaguchi M. , Hayashi Y. , Hirose F. , Matsuoka S. , Moriuchi T. , Shiroishi T. , Moriwaki K. , Matsukage A.
Nucleic Acids Res.19:2403-2410(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: C57BL/6.
tissue: Spleen.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: FVB/N.
tissue: Mammary gland.
4.

"Cyclin mRNA and protein expression in recombinant interleukin 2-stimulated cloned murine T lymphocytes."
Shipman P.M. , Sabath D.E. , Fischer A.H. , Comber P.G. , Sullivan K. , Tan E.M. , Prystowsky M.B.
J. Cell. Biochem.38:189-198(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-42
tissue: T-cell.
5.

"The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34."
Brown S.M. , MacLean A.R. , McKie E.A. , Harland J.
J. Virol.71:9442-9449(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP1R15A AND HHV-1 ICP34.5
6.

"Characterization of the genomic structure and expression of the mouse Apex2 gene."
Ide Y. , Tsuchimoto D. , Tominaga Y. , Iwamoto Y. , Nakabeppu Y.
Genomics81:47-57(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APEX2
7.

"Tyrosine phosphorylation controls PCNA function through protein stability."
Wang S.C. , Nakajima Y. , Yu Y.L. , Xia W. , Chen C.T. , Yang C.C. , McIntush E.W. , Li L.Y. , Hawke D.H. , Kobayashi R. , Hung M.C.
Nat. Cell Biol.8:1359-1368(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-211
8.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-80;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
9.

"RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication."
Vannier J.B. , Sandhu S. , Petalcorin M.I. , Wu X. , Nabi Z. , Ding H. , Boulton S.J.
Science342:239-242(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RTEL1;SUBCELLULAR LOCATION

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