Pcna ELISA Kit for Rat(Rattus norvegicus) | EIAab.comPcna ELISA Kit for Rat(Rattus norvegicus)

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Pcna (Gene name),

Proliferating cell nuclear antigen (Protein name ), PCNA_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pcna;

Protein name:

Proliferating cell nuclear antigen(PCNA);

Alternative:

Cyclin;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotrimer (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Forms a ternary complex with DNTTIP2 and core histone. Interacts with PPP1R15A. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH (By similarity). Interacts with KCTD10. Interacts with NUDT15 (By similarity). Interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Interacts with DDX11.

Function:

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities (By similarity). Has to be loaded onto DNA in order to be able to stimulate APEX2.

Subcellular Location:

Nucleus Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.

Protein Attributes:

Sequence length:

261

Sequence:

50:

100:

150:

200:

250:

261:

LAPKIEDEEG | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:25737

Pfam:

PF02747

STRING:

10116.ENSRNOP00000028887

SMR:

P04961

String:

P04961

UniGene:

Rn.223

Uniprot:

P04961

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ELISA Kit for Rat PCNA

Cat.:

E0591m

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Packing:

96T

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ELISA Kit for Rat PCNA

Cat.:

E0591h

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96T

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ELISA Kit for Rat PCNA

Cat.:

E0591r

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96T

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ELISA Kit for Rat PCNA

Cat.:

E0591b

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96T

ELISA Kit for Rat PCNA

Cat.:

E0591c

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96T

CLIA Kit for Rat PCNA

Cat.:

U0591c

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96T

CLIA Kit for Rat PCNA

Cat.:

U0591h

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96T

CLIA Kit for Rat PCNA

Cat.:

U0591b

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Packing:

96T

CLIA Kit for Rat PCNA

Cat.:

U0591m

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Packing:

96T

CLIA Kit for Rat PCNA

Cat.:

U0591r

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Packing:

96T

Polyclonal Antibody for Rat PCNA

Cat.:

P0591Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat PCNA

Cat.:

P0591Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat PCNA

Cat.:

P0591Rb-r

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40ug/0.2ml

Monoclonal Antibody for Rat PCNA

Protein for Rat PCNA

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclin."
Matsumoto K. , Moriuchi T. , Koji T. , Nakan P.K.
EMBO J.6:637-642(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Wistar Furth.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pituitary.
3.

"A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta."
Zhou J. , Ren K. , Liu X. , Xiong X. , Hu X. , Zhang J.
Biochim. Biophys. Acta1729:200-203(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCTD10
strain: Wistar.

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