"The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications."
Benjannet S. , Rhainds D. , Hamelin J. , Nassoury N. , Seidah N.G.
J. Biol. Chem.281:30561-30572(2006) [PubMed] [Europe PMC] [Abstract]

"The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR."
Nassoury N. , Blasiole D.A. , Tebon Oler A. , Benjannet S. , Hamelin J. , Poupon V. , McPherson P.S. , Attie A.D. , Prat A. , Seidah N.G.
Traffic8:718-732(2007) [PubMed] [Europe PMC] [Abstract]

"Self-association of human PCSK9 correlates with its LDLR-degrading activity."
Fan D. , Yancey P.G. , Qiu S. , Ding L. , Weeber E.J. , Linton M.F. , Fazio S.
Biochemistry47:1631-1639(2008) [PubMed] [Europe PMC] [Abstract]

"PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1."
Jonas M.C. , Costantini C. , Puglielli L.
EMBO Rep.9:916-922(2008) [PubMed] [Europe PMC] [Abstract]

"PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans."
Dewpura T. , Raymond A. , Hamelin J. , Seidah N.G. , Mbikay M. , Chretien M. , Mayne J.
FEBS J.275:3480-3493(2008) [PubMed] [Europe PMC] [Abstract]

"The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2."
Poirier S. , Mayer G. , Benjannet S. , Bergeron E. , Marcinkiewicz J. , Nassoury N. , Mayer H. , Nimpf J. , Prat A. , Seidah N.G.
J. Biol. Chem.283:2363-2372(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradation."
Chen Y. , Wang H. , Yu L. , Yu X. , Qian Y.W. , Cao G. , Wang J.
Biochem. Biophys. Res. Commun.415:515-518(2011) [PubMed] [Europe PMC] [Abstract]

"A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor."
Yamamoto T. , Lu C. , Ryan R.O.
J. Biol. Chem.286:5464-5470(2011) [PubMed] [Europe PMC] [Abstract]

"Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein."
Du F. , Hui Y. , Zhang M. , Linton M.F. , Fazio S. , Fan D.
J. Biol. Chem.286:43054-43061(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
Sun H. , Samarghandi A. , Zhang N. , Yao Z. , Xiong M. , Teng B.B.
Arterioscler. Thromb. Vasc. Biol.32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]

"PCSK9: an enigmatic protease."
Lopez D.
Biochim. Biophys. Acta1781:184-191(2008) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of PCSK9 function."
Lambert G. , Charlton F. , Rye K.A. , Piper D.E.
Atherosclerosis203:1-7(2009) [PubMed] [Europe PMC] [Abstract]

"The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis."
Mousavi S.A. , Berge K.E. , Leren T.P.
J. Intern. Med.266:507-519(2009) [PubMed] [Europe PMC] [Abstract]

"Nucleic acid molecules derived from rat brain and programmed cell death models."
Chiang L.W.

"Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species."
Ding K. , McDonough S.J. , Kullo I.J.
PLoS ONE2:E1098-E1098(2007) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , Yamamoto J. , Saito K. , Kawai Y. , Isono Y. , Nakamura Y. , Nagahari K. , Murakami K. , Yasuda T. , Iwayanagi T. , Wagatsuma M. , Shiratori A. , Sudo H. , Hosoiri T. , Kaku Y. , Kodaira H. , Kondo H. , Sugawara M. , Takahashi M. , Kanda K. , Yokoi T. , Furuya T. , Kikkawa E. , Omura Y. , Abe K. , Kamihara K. , Katsuta N. , Sato K. , Tanikawa M. , Yamazaki M. , Ninomiya K. , Ishibashi T. , Yamashita H. , Murakawa K. , Fujimori K. , Tanai H. , Kimata M. , Watanabe M. , Hiraoka S. , Chiba Y. , Ishida S. , Ono Y. , Takiguchi S. , Watanabe S. , Yosida M. , Hotuta T. , Kusano J. , Kanehori K. , Takahashi-Fujii A. , Hara H. , Tanase T.-O. , Nomura Y. , Togiya S. , Komai F. , Hara R. , Takeuchi K. , Arita M. , Imose N. , Musashino K. , Yuuki H. , Oshima A. , Sasaki N. , Aotsuka S. , Yoshikawa Y. , Matsunawa H. , Ichihara T. , Shiohata N. , Sano S. , Moriya S. , Momiyama H. , Satoh N. , Takami S. , Terashima Y. , Suzuki O. , Nakagawa S. , Senoh A. , Mizoguchi H. , Goto Y. , Shimizu F. , Wakebe H. , Hishigaki H. , Watanabe T. , Sugiyama A. , Takemoto M. , Kawakami B. , Yamazaki M. , Watanabe K. , Kumagai A. , Itakura S. , Fukuzumi Y. , Fujimori Y. , Komiyama M. , Tashiro H. , Tanigami A. , Fujiwara T. , Ono T. , Yamada K. , Fujii Y. , Ozaki K. , Hirao M. , Ohmori Y. , Kawabata A. , Hikiji T. , Kobatake N. , Inagaki H. , Ikema Y. , Okamoto S. , Okitani R. , Kawakami T. , Noguchi S. , Itoh T. , Shigeta K. , Senba T. , Matsumura K. , Nakajima Y. , Mizuno T. , Morinaga M. , Sasaki M. , Togashi T. , Oyama M. , Hata H. , Watanabe M. , Komatsu T. , Mizushima-Sugano J. , Satoh T. , Shirai Y. , Takahashi Y. , Nakagawa K. , Okumura K. , Nagase T. , Nomura N. , Kikuchi H. , Masuho Y. , Yamashita R. , Nakai K. , Yada T. , Nakamura Y. , Ohara O. , Isogai T. , Sugano S. more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

SeattleSNPs variation discovery resource
Submitted (2004-11) to the EMBL/GenBank/DDBJ databases

NHLBI resequencing and genotyping service (RS&G)
Submitted (2008-12) to the EMBL/GenBank/DDBJ databases

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , Atkinson A. , Cooper R. , Jones C. , Hall R.E. , Andrews T.D. , Lloyd C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Anderson F. , Andrew R.W. , Ashwell R.I.S. , Aubin K. , Babbage A.K. , Bagguley C.L. , Bailey J. , Beasley H. , Bethel G. , Bird C.P. , Bray-Allen S. , Brown J.Y. , Brown A.J. , Buckley D. , Burton J. , Bye J. , Carder C. , Chapman J.C. , Clark S.Y. , Clarke G. , Clee C. , Cobley V. , Collier R.E. , Corby N. , Coville G.J. , Davies J. , Deadman R. , Dunn M. , Earthrowl M. , Ellington A.G. , Errington H. , Frankish A. , Frankland J. , French L. , Garner P. , Garnett J. , Gay L. , Ghori M.R.J. , Gibson R. , Gilby L.M. , Gillett W. , Glithero R.J. , Grafham D.V. , Griffiths C. , Griffiths-Jones S. , Grocock R. , Hammond S. , Harrison E.S.I. , Hart E. , Haugen E. , Heath P.D. , Holmes S. , Holt K. , Howden P.J. , Hunt A.R. , Hunt S.E. , Hunter G. , Isherwood J. , James R. , Johnson C. , Johnson D. , Joy A. , Kay M. , Kershaw J.K. , Kibukawa M. , Kimberley A.M. , King A. , Knights A.J. , Lad H. , Laird G. , Lawlor S. , Leongamornlert D.A. , Lloyd D.M. , Loveland J. , Lovell J. , Lush M.J. , Lyne R. , Martin S. , Mashreghi-Mohammadi M. , Matthews L. , Matthews N.S.W. , McLaren S. , Milne S. , Mistry S. , Moore M.J.F. , Nickerson T. , O'Dell C.N. , Oliver K. , Palmeiri A. , Palmer S.A. , Parker A. , Patel D. , Pearce A.V. , Peck A.I. , Pelan S. , Phelps K. , Phillimore B.J. , Plumb R. , Rajan J. , Raymond C. , Rouse G. , Saenphimmachak C. , Sehra H.K. , Sheridan E. , Shownkeen R. , Sims S. , Skuce C.D. , Smith M. , Steward C. , Subramanian S. , Sycamore N. , Tracey A. , Tromans A. , Van Helmond Z. , Wall M. , Wallis J.M. , White S. , Whitehead S.L. , Wilkinson J.E. , Willey D.L. , Williams H. , Wilming L. , Wray P.W. , Wu Z. , Coulson A. , Vaudin M. , Sulston J.E. , Durbin R.M. , Hubbard T. , Wooster R. , Dunham I. , Carter N.P. , McVean G. , Ross M.T. , Harrow J. , Olson M.V. , Beck S. , Rogers J. , Bentley D.R. more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , Yooseph S. , Lu F. , Nusskern D.R. , Shue B.C. , Zheng X.H. , Zhong F. , Delcher A.L. , Huson D.H. , Kravitz S.A. , Mouchard L. , Reinert K. , Remington K.A. , Clark A.G. , Waterman M.S. , Eichler E.E. , Adams M.D. , Hunkapiller M.W. , Myers E.W. , Venter J.C. more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

"The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
Seidah N.G. , Benjannet S. , Wickham L. , Marcinkiewicz J. , Jasmin S.B. , Stifani S. , Basak A. , Prat A. , Chretien M.
Proc. Natl. Acad. Sci. U.S.A.100:928-933(2003) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of Narc 1, a novel proteinase related to proteinase K."
Naureckiene S. , Ma L. , Sreekumar K. , Purandare U. , Lo C.F. , Huang Y. , Chiang L.W. , Grenier J.M. , Ozenberger B.A. , Jacobsen J.S. , Kennedy J.D. , DiStefano P.S. , Wood A. , Bingham B.
Arch. Biochem. Biophys.420:55-67(2003) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"PCSK9: a convertase that coordinates LDL catabolism."
Horton J.D. , Cohen J.C. , Hobbs H.H.
J. Lipid Res.50:S172-S177(2009) [PubMed] [Europe PMC] [Abstract]

"Proprotein convertase subtilisin/kexin type 9 (PCSK9): from structure-function relation to therapeutic inhibition."
Tibolla G. , Norata G.D. , Artali R. , Meneghetti F. , Catapano A.L.
Nutr. Metab. Cardiovasc. Dis.21:835-843(2011) [PubMed] [Europe PMC] [Abstract]

"Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease."
Abifadel M. , Rabes J.P. , Devillers M. , Munnich A. , Erlich D. , Junien C. , Varret M. , Boileau C.
Hum. Mutat.30:520-529(2009) [PubMed] [Europe PMC] [Abstract]

"Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients."
Slimani A. , Jelassi A. , Jguirim I. , Najah M. , Rebhi L. , Omezzine A. , Maatouk F. , Hamda K.B. , Kacem M. , Rabes J.P. , Abifadel M. , Boileau C. , Rouis M. , Slimane M.N. , Varret M.
Atherosclerosis222:158-166(2012) [PubMed] [Europe PMC] [Abstract]

"Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)."
Sharotri V. , Collier D.M. , Olson D.R. , Zhou R. , Snyder P.M.
J. Biol. Chem.287:19266-19274(2012) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol."
Piper D.E. , Jackson S. , Liu Q. , Romanow W.G. , Shetterly S. , Thibault S.T. , Shan B. , Walker N.P.
Structure15:545-552(2007) [PubMed] [Europe PMC] [Abstract]

"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia."
Abifadel M. , Varret M. , Rabes J.-P. , Allard D. , Ouguerram K. , Devillers M. , Cruaud C. , Benjannet S. , Wickham L. , Erlich D. , Derre A. , Villeger L. , Farnier M. , Beucler I. , Bruckert E. , Chambaz J. , Chanu B. , Lecerf J.-M. , Luc G. , Moulin P. , Weissenbach J. , Prat A. , Krempf M. , Junien C. , Seidah N.G. , Boileau C. more...
Nat. Genet.34:154-156(2003) [PubMed] [Europe PMC] [Abstract]

"A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol."
Kotowski I.K. , Pertsemlidis A. , Luke A. , Cooper R.S. , Vega G.L. , Cohen J.C. , Hobbs H.H.
Am. J. Hum. Genet.78:410-422(2006) [PubMed] [Europe PMC] [Abstract]

"The molecular basis of familial hypercholesterolemia in Lebanon: spectrum of LDLR mutations and role of PCSK9 as a modifier gene."
Abifadel M. , Rabes J.-P. , Jambart S. , Halaby G. , Gannage-Yared M.-H. , Sarkis A. , Beaino G. , Varret M. , Salem N. , Corbani S. , Aydenian H. , Junien C. , Munnich A. , Boileau C.
Hum. Mutat.30:E682-E691(2009) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels."
Huijgen R. , Sjouke B. , Vis K. , de Randamie J.S. , Defesche J.C. , Kastelein J.J. , Hovingh G.K. , Fouchier S.W.
Hum. Mutat.33:448-455(2012) [PubMed] [Europe PMC] [Abstract]