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Index > Protein center > PDCD4(Gene name) > Human
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  • PDCD4 (Gene name),
  • Programmed cell death protein 4 (Protein name ),  PDCD4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PDCD4(H731);
    Protein name:
    Programmed cell death protein 4;
    Alternative:
    Nuclear antigen H731-like;Neoplastic transformation inhibitor protein;Protein 197/15a;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
    Function:
    Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
    Subcellular Location:
    Nucleus Cytoplasm Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
    Protein Attributes:
    Sequence length:
    469
    Sequence:
    50:
    MDVENEQILN | VNPADPDNLS | DSLFSGDEEN | AGTEEIKNEI | NGNWISASSI | 
    100:
    NEARINAKAK | RRLRKNSSRD | SGRGDSVSDS | GSDALRSGLT | VPTSPKGRLL | 
    150:
    DRRSRSGKGR | GLPKKGGAGG | KGVWGTPGQV | YDVEEVDVKD | PNYDDDQENC | 
    200:
    VYETVVLPLD | ERAFEKTLTP | IIQEYFEHGD | TNEVAEMLRD | LNLGEMKSGV | 
    250:
    PVLAVSLALE | GKASHREMTS | KLLSDLCGTV | MSTTDVEKSF | DKLLKDLPEL | 
    300:
    ALDTPRAPQL | VGQFIARAVG | DGILCNTYID | SYKGTVDCVQ | ARAALDKATV | 
    350:
    LLSMSKGGKR | KDSVWGSGGG | QQSVNHLVKE | IDMLLKEYLL | SGDISEAEHC | 
    400:
    LKELEVPHFH | HELVYEAIIM | VLESTGESTF | KMILDLLKSL | WKSSTITVDQ | 
    450:
    MKRGYERIYN | EIPDINLDVP | HSYSVLERFV | EECFQAGIIS | KQLRDLCPSR | 
    469:
    GRKRFVSEGD | GGRLKPESY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Programmed cell death protein 4
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    E2393h
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    ELISA Kit for Human Programmed cell death protein 4
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    E2393c
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    ELISA Kit for Human Programmed cell death protein 4
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    ELISA Kit for Human Programmed cell death protein 4
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    E2393r
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    96T
    CLIA Kit for Human Programmed cell death protein 4
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    U2393r
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    CLIA Kit for Human Programmed cell death protein 4
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    U2393c
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    CLIA Kit for Human Programmed cell death protein 4
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    U2393h
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    CLIA Kit for Human Programmed cell death protein 4
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    U2393m
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    Polyclonal Antibody for Human Programmed cell death protein 4
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    P2393Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Programmed cell death protein 4
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    P2393Rb-h
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    Polyclonal Antibody for Human Programmed cell death protein 4
    Cat.:
    P2393Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Programmed cell death protein 4
    Monoclonal Antibody for Human Programmed cell death protein 4
    Monoclonal Antibody for Human Programmed cell death protein 4
    Monoclonal Antibody for Human Programmed cell death protein 4
    Monoclonal Antibody for Human Programmed cell death protein 4
    Protein for Human Programmed cell death protein 4
    Protein for Human Programmed cell death protein 4
    Protein for Human Programmed cell death protein 4
    Protein for Human Programmed cell death protein 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
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      "Isolation of a novel gene from a human cell line with Pr-28 MAb which recognizes a nuclear antigen involved in the cell cycle."
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      tissue: Glial tumor.
    2. 2.
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      Azzoni L. , Zatsepina O. , Abebe B. , Bennett I.M. , Kanakaraj P. , Perussia B.
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      tissue: Blood.
    3. 3.
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    4. 4.
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      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-36
      tissue: Spleen.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS VAL-36 AND TYR-48
      tissue: Brain.
      tissue: Skin.
    7. 7.
      "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody."
      Yoshinaga H. , Matsuhashi S. , Fujiyama C. , Masaki Z.
      Pathol. Int.49:1067-1077(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis."
      Chen Y. , Knosel T. , Kristiansen G. , Pietas A. , Garber M.E. , Matsuhashi S. , Ozaki I. , Petersen I.
      J. Pathol.200:640-646(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 9.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
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      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "Akt phosphorylates and regulates Pdcd4 tumor suppressor protein."
      Palamarchuk A. , Efanov A. , Maximov V. , Aqeilan R.I. , Croce C.M. , Pekarsky Y.
      Cancer Res.65:11282-11286(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-67 AND SER-457 BY PKB;FUNCTION;MUTAGENESIS OF SER-67 AND SER-457;SUBCELLULAR LOCATION
    11. 11.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-152;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion."
      Yang H.-S. , Matthews C.P. , Clair T. , Wang Q. , Baker A.R. , Li C.-C. , Tan T.-H. , Colburn N.H.
      Mol. Cell. Biol.26:1297-1306(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    14. 14.
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      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth."
      Dorrello N.V. , Peschiaroli A. , Guardavaccaro D. , Colburn N.H. , Sherman N.E. , Pagano M.
      Science314:467-471(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-67 BY RPS6KB1;PHOSPHODEGRON MOTIF;INTERACTION WITH BTRC AND FBXW11;UBIQUITINATION;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF SER-67; SER-71 AND SER-76
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-78; SER-80 AND SER-94;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76; SER-78; SER-94 AND SER-457;VARIANT [LARGE SCALE ANALYSIS] VAL-36;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Solution structure of the MA3 domain of human programmed cell death 4."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-04) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 320-450
    22. 22.
      "PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains."
      Suzuki C. , Garces R.G. , Edmonds K.A. , Hiller S. , Hyberts S.G. , Marintchev A. , Wagner G.
      Proc. Natl. Acad. Sci. U.S.A.105:3274-3279(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 157-320;FUNCTION;DOMAIN;INTERACTION WITH EIF4A;SUBUNIT
    23. 23.
      "Structural basis for translational inhibition by the tumour suppressor Pdcd4."
      Loh P.G. , Yang H.S. , Walsh M.A. , Wang Q. , Wang X. , Cheng Z. , Liu D. , Song H.
      EMBO J.28:274-285(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 157-469;FUNCTION;INTERACTION WITH EIF4A1 AND EIF4G;SUBUNIT;MUTAGENESIS OF GLU-174; GLU-210; GLU-249; LEU-252; ASP-253; PRO-255; HIS-358; ASP-414; ASP-418 AND PRO-420
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 163-469 IN COMPLEX WITH EIF4A1;FUNCTION;SUBUNIT;DOMAIN;MUTAGENESIS OF ASP-253; MET-333; GLU-337; LEU-340; PHE-359 AND HIS-361
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-120
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