Protein name:
cGMP-specific 3',5'-cyclic phosphodiesterase ;
Alternative:
cGMP-binding cGMP-specific phosphodiesterase (CGB-PDE) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
Subcellular Location:
N/A
Protein Attributes:
50:
MERAGPSFGQ | QRQQQQPQQQ | KQQQRDQDSV | EAWLDDHWDF | TFSYFVRKAT |
100:
REMVNAWFAE | RVHTIPVCKE | GIRGHTESCS | CPLQQSPRAD | NSAPGTPTRK |
150:
ISASEFDRPL | RPIVVKDSEG | TVSFLSDSEK | KEQMPLTPPR | FDHDEGDQCS |
200:
RLLELVKDIS | SHLDVTALCH | KIFLHIHGLI | SADRYSLFLV | CEDSSNDKFL |
250:
ISRLFDVAEG | STLEEVSNNC | IRLEWNKGIV | GHVAALGEPL | NIKDAYEDPR |
300:
FNAEVDQITG | YKTQSILCMP | IKNHREEVVG | VAQAINKKSG | NGGTFTEKDE |
350:
KDFAAYLAFC | GIVLHNAQLY | ETSLLENKRN | QVLLDLASLI | FEEQQSLEVI |
400:
LKKIAATIIS | FMQVQKCTIF | IVDEDCSDSF | SSVFHMECEE | LEKSSDTLTR |
450:
EHDANKINYM | YAQYVKNTME | PLNIPDVSKD | KRFPWTTENT | GNVNQQCIRS |
500:
LLCTPIKNGK | KNKVIGVCQL | VNKMEENTGK | VKPFNRNDEQ | FLEAFVIFCG |
550:
LGIQNTQMYE | AVERAMAKQM | VTLEVLSYHA | SAAEEETREL | QSLAAAVVPS |
600:
AQTLKITDFS | FSDFELSDLE | TALCTIRMFT | DLNLVQNFQM | KHEVLCRWIL |
650:
SVKKNYRKNV | AYHNWRHAFN | TAQCMFAALK | AGKIQNKLTD | LEILALLIAA |
700:
LSHDLDHRGV | NNSYIQRSEH | PLAQLYCHSI | MEHHHFDQCL | MILNSPGNQI |
750:
LSGLSIEEYK | TTLKIIKQAI | LATDLALYIK | RRGEFFELIR | KNQFNLEDPH |
800:
QKELFLAMLM | TACDLSAITK | PWPIQQRIAE | LVATEFFDQG | DRERKELNIE |
850:
PTDLMNREKK | NKIPSMQVGF | IDAICLQLYE | ALTHVSEDCF | PLLDGCRKNR |
875:
QKWQALAEQQ | EKMLINGESG | QAKRN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Dog
ELISA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
ELISA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
ELISA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
ELISA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
ELISA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
CLIA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
CLIA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
CLIA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
CLIA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
CLIA Kit for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Polyclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Polyclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Polyclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Polyclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Polyclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Monoclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Monoclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Monoclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Monoclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Monoclonal Antibody for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Protein for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Protein for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Protein for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Protein for Human cGMP-specific 3',5'-cyclic phosphodiesterase
Protein for Human cGMP-specific 3',5'-cyclic phosphodiesterase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase."
Loughney K.
,
Hill T.R.
,
Florio V.A.
,
Uher L.
,
Rosman G.J.
,
Wolda S.L.
,
Jones B.A.
,
Howard M.L.
,
McAllister-Lucas L.M.
,
Sonnenburg W.K.
,
Francis S.H.
,
Corbin J.D.
,
Beavo J.A.
,
Ferguson K.
Gene216:139-147(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE5A1 AND PDE5A2);VARIANT VAL-93
2.
"Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene."
Yanaka N.
,
Kotera J.
,
Ohtsuka A.
,
Akatsuka H.
,
Imai Y.
,
Michibata H.
,
Fujishige K.
,
Kawai E.
,
Takebayashi S.
,
Okumura K.
,
Omori K.
Eur. J. Biochem.255:391-399(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM PDE5A1);VARIANT VAL-93
tissue :
Lung .
tissue :
Placenta .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE5A1);VARIANT VAL-93
tissue :
Prostate .
tissue :
Skeletal muscle .
4.
"Molecular cloning and characterization of human cGMP-specific phosphodiesterase 5A2 cDNA."
Kotera J.
,
Imai Y.
,
Omori K.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE5A2);VARIANT VAL-93
tissue :
Lung .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE5A2)
tissue :
Colon carcinoma .
6.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE5A1);VARIANT VAL-93
tissue :
Thalamus .
7.
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W.
,
Graves T.A.
,
Fulton R.S.
,
Fulton L.A.
,
Pepin K.H.
,
Minx P.
,
Wagner-McPherson C.
,
Layman D.
,
Wylie K.
,
Sekhon M.
,
Becker M.C.
,
Fewell G.A.
,
Delehaunty K.D.
,
Miner T.L.
,
Nash W.E.
,
Kremitzki C.
,
Oddy L.
,
Du H.
,
Sun H.
,
Bradshaw-Cordum H.
,
Ali J.
,
Carter J.
,
Cordes M.
,
Harris A.
,
Isak A.
,
van Brunt A.
,
Nguyen C.
,
Du F.
,
Courtney L.
,
Kalicki J.
,
Ozersky P.
,
Abbott S.
,
Armstrong J.
,
Belter E.A.
,
Caruso L.
,
Cedroni M.
,
Cotton M.
,
Davidson T.
,
Desai A.
,
Elliott G.
,
Erb T.
,
Fronick C.
,
Gaige T.
,
Haakenson W.
,
Haglund K.
,
Holmes A.
,
Harkins R.
,
Kim K.
,
Kruchowski S.S.
,
Strong C.M.
,
Grewal N.
,
Goyea E.
,
Hou S.
,
Levy A.
,
Martinka S.
,
Mead K.
,
McLellan M.D.
,
Meyer R.
,
Randall-Maher J.
,
Tomlinson C.
,
Dauphin-Kohlberg S.
,
Kozlowicz-Reilly A.
,
Shah N.
,
Swearengen-Shahid S.
,
Snider J.
,
Strong J.T.
,
Thompson J.
,
Yoakum M.
,
Leonard S.
,
Pearman C.
,
Trani L.
,
Radionenko M.
,
Waligorski J.E.
,
Wang C.
,
Rock S.M.
,
Tin-Wollam A.-M.
,
Maupin R.
,
Latreille P.
,
Wendl M.C.
,
Yang S.-P.
,
Pohl C.
,
Wallis J.W.
,
Spieth J.
,
Bieri T.A.
,
Berkowicz N.
,
Nelson J.O.
,
Osborne J.
,
Ding L.
,
Meyer R.
,
Sabo A.
,
Shotland Y.
,
Sinha P.
,
Wohldmann P.E.
,
Cook L.L.
,
Hickenbotham M.T.
,
Eldred J.
,
Williams D.
,
Jones T.A.
,
She X.
,
Ciccarelli F.D.
,
Izaurralde E.
,
Taylor J.
,
Schmutz J.
,
Myers R.M.
,
Cox D.R.
,
Huang X.
,
McPherson J.D.
,
Mardis E.R.
,
Clifton S.W.
,
Warren W.C.
,
Chinwalla A.T.
,
Eddy S.R.
,
Marra M.A.
,
Ovcharenko I.
,
Furey T.S.
,
Miller W.
,
Eichler E.E.
,
Bork P.
,
Suyama M.
,
Torrents D.
,
Waterston R.H.
,
Wilson R.K.
more...
Nature434:724-731(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PDE5A1)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 157-411
tissue :
Trabecular meshwork .
10.
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Cited for : PHOSPHORYLATION BY PRKG1
11.
"Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules."
Sung B.-J.
,
Hwang K.Y.
,
Jeon Y.H.
,
Lee J.I.
,
Heo Y.-S.
,
Kim J.H.
,
Moon J.
,
Yoon J.M.
,
Hyun Y.-L.
,
Kim E.
,
Eum S.J.
,
Park S.-Y.
,
Lee J.-O.
,
Lee T.G.
,
Ro S.
,
Cho J.M.
Nature425:98-102(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 537-860 IN COMPLEX WITH THE INHIBITORS SILDENAFIL; TADALAFIL AND VARDENAFIL;METAL-BINDING