Pdgfa ELISA Kit for Mouse(Mus musculus) | EIAab.comPdgfa ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Pdgfa (Gene name),

Platelet-derived growth factor subunit A (Protein name ), PDGFA_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Pdgfa;

Protein name:

Platelet-derived growth factor subunit A(PDGF subunit A);

Alternative:

Platelet-derived growth factor A chain;PDGF-1;Platelet-derived growth factor alpha polypeptide;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.

Function:

Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

211

Sequence:

50:

MRTWACLLLL | GCGYLAHALA | EEAEIPRELI | ERLARSQIHS | IRDLQRLLEI |

100:

DSVGAEDALE | TSLRAHGSHA | INHVPEKRPV | PIRRKRSIEE | AVPAVCKTRT |

150:

VIYEIPRSQV | DPTSANFLIW | PPCVEVKRCT | GCCNTSSVKC | QPSRVHHRSV |

200:

KVAKVEYVRK | KPKLKEVQVR | LEEHLECACA | TSNLNPDHRE | EETGRRRESG |

211:

KNRKRKRLKP | T

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

SMR:

UniGene:

Pfam:

String:

Uniprot:

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ELISA Kit for Mouse PDGF subunit A

MSDS:

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ELISA Kit for Mouse PDGF subunit A

Cat.:

E0112h

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96T

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ELISA Kit for Mouse PDGF subunit A

Cat.:

E0112m

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MSDS:

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96T

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ELISA Kit for Mouse PDGF subunit A

Cat.:

E0112b

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MSDS:

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96T

ELISA Kit for Mouse PDGF subunit A

Cat.:

E0112r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PDGF subunit A

Cat.:

U0112r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PDGF subunit A

Cat.:

U0112m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PDGF subunit A

Cat.:

U0112b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PDGF subunit A

Cat.:

U0112h

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MSDS:

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96T

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CLIA Kit for Mouse PDGF subunit A

MSDS:

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Polyclonal Antibody for Mouse PDGF subunit A

Polyclonal Antibody for Mouse PDGF subunit A

Cat.:

P0112Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PDGF subunit A

Cat.:

P0112Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse PDGF subunit A

Polyclonal Antibody for Mouse PDGF subunit A

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P0112Rb-h

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Monoclonal Antibody for Mouse PDGF subunit A

Monoclonal Antibody for Mouse PDGF subunit A

Monoclonal Antibody for Mouse PDGF subunit A

Monoclonal Antibody for Mouse PDGF subunit A

Monoclonal Antibody for Mouse PDGF subunit A

Protein for Mouse PDGF subunit A

Protein for Mouse PDGF subunit A

Protein for Mouse PDGF subunit A

Protein for Mouse PDGF subunit A

Protein for Mouse PDGF subunit A

R&D Technical Data

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s

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Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤6.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤11%

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Recovery

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Recovery was determined by spiking various levels of PDGFA into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	102	99-108
Plasma	101	96-103

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of PDGFA and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	98-105%	97-107%	95-108%	99-107%
EDTA plasma(n=5)	97-106%	98-105%	98-105%	96-106%
heparin plasma(n=5)	99-105%	100-104%	96-107%	95-107%

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References

1.

"Characterization of the mouse PDGF A-chain gene. Evolutionary conservation of gene structure, nucleotide sequence and alternative splicing."
Rorsman F. , Betsholtz C.
Growth Factors6:303-313(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LONG AND SHORT)
strain: BALB/c.
2.

"Selective expression of PDGF A and its receptor during early mouse embryogenesis."
Mercola M. , Wang C. , Kelly J. , Brownlee C. , Jackson-Grusby L. , Stiles C. , Bowen-Pope D.F.
Dev. Biol.138:114-122(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
strain: F9.
3.

"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis."
Bostrom H. , Willetts K. , Pekny M. , Leveen P. , Lindahl P. , Hedstrand H. , Pekna M. , Hellstrom M. , Gebre-Medhin S. , Schalling M. , Nilsson M. , Kurland S. , Tornell J. , Heath J.K. , Betsholtz C.
Cell85:863-873(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
4.

"Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development."
Lindahl P. , Karlsson L. , Hellstrom M. , Gebre-Medhin S. , Willetts K. , Heath J.K. , Betsholtz C.
Development124:3943-3953(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
5.

"Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice."
Fruttiger M. , Karlsson L. , Hall A.C. , Abramsson A. , Calver A.R. , Bostrom H. , Willetts K. , Bertold C.H. , Heath J.K. , Betsholtz C. , Richardson W.D.
Development126:457-467(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
6.

"Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis."
Karlsson L. , Lindahl P. , Heath J.K. , Betsholtz C.
Development127:3457-3466(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
7.

"Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice."
Gnessi L. , Basciani S. , Mariani S. , Arizzi M. , Spera G. , Wang C. , Bondjers C. , Karlsson L. , Betsholtz C.
J. Cell Biol.149:1019-1026(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
8.

"PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis."
Bostrom H. , Gritli-Linde A. , Betsholtz C.
Dev. Dyn.223:155-162(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
9.

"Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury."
Taneda S. , Hudkins K.L. , Topouzis S. , Gilbertson D.G. , Ophascharoensuk V. , Truong L. , Johnson R.J. , Alpers C.E.
J. Am. Soc. Nephrol.14:2544-2555(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"PDGF signaling in cells and mice."
Tallquist M. , Kazlauskas A.
Cytokine Growth Factor Rev.15:205-213(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"Insight into the physiological functions of PDGF through genetic studies in mice."
Betsholtz C.
Cytokine Growth Factor Rev.15:215-228(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;DISRUPTION PHENOTYPE
12.

"Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells."
Wu E. , Palmer N. , Tian Z. , Moseman A.P. , Galdzicki M. , Wang X. , Berger B. , Zhang H. , Kohane I.S.
PLoS ONE3:E3794-E3794(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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