Protein name:
Platelet-derived growth factor C (PDGF-C) ;
Alternative:
Spinal cord-derived growth factor (rScdfg) ;Fallotein ;VEGF-E ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked (By similarity). Interacts (via CUB domain) with PLAT (via kringle domain).
Function:
Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.
Subcellular Location:
Cytoplasm
Secreted
Nucleus
Cytoplasmic granule
Sumoylated form is predominant in the nucleus (By similarity). Stored in alpha granules in platelets (By similarity). Membrane associated when bound to receptors.
Protein Attributes:
50:
MLLLGLLLLT | SALAGQRTGT | RAESNLSSKL | QLSSDKEQNG | VQDPRHERVV |
100:
TISGNGSIHS | PKFPHTYPRN | TVLVWRLVAV | DENVRIQLTF | DERFGLEDPE |
150:
DDLCKYDFVE | VEEPSDGSVL | GRWCGSGTVP | GKQTSKGNHI | RIRFVSDEYF |
200:
PSEPGFCIHY | SIIMPQVTET | TSPSVLPPSA | LSLDLLNNAV | TAFSTVEELI |
250:
RFLEPDRWQI | DLDSLYKPTW | PLLGKAFLYG | KKSKAVNLNL | LKEEVKLYSC |
300:
TPRNFSVSIR | EELKRTDTIF | WPGCLLVKRC | GGNCACCLHN | CNECQCVPRK |
345:
VTKKYHEVLQ | LRPKIGVKGL | HKSLTDVALE | HHEECDCVCR | GNTEG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Chicken
Polyclonal Antibody for Rat PDGF-C
Polyclonal Antibody for Rat PDGF-C
Polyclonal Antibody for Rat PDGF-C
Polyclonal Antibody for Rat PDGF-C
Monoclonal Antibody for Rat PDGF-C
Monoclonal Antibody for Rat PDGF-C
Monoclonal Antibody for Rat PDGF-C
Monoclonal Antibody for Rat PDGF-C
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Wistar .
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 42-299
strain :
Sprague-Dawley .
tissue :
Skin .
3.
"Expression of a novel PDGF isoform, PDGF-C, in normal and diseased rat kidney."
Eitner F.
,
Ostendorf T.
,
Van Roeyen C.
,
Kitahara M.
,
Li X.
,
Aase K.
,
Grone H.J.
,
Eriksson U.
,
Floege J.
J. Am. Soc. Nephrol.13:910-917(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION BY FIBROGENESIS
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION BY INDOXYL SULFATE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE