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Index > Protein center > PDK1(Gene name) > Human
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  • PDK1 (Gene name),
  • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial (Protein name ),  PDK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PDK1(PDHK1);
    Protein name:
    [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial;
    Alternative:
    Pyruvate dehydrogenase kinase isoform 1(PDH kinase 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    436
    Sequence:
    50:
    MRLARLLRGA | ALAGPGPGLR | AAGFSRSFSS | DSGSSPASER | GVPGQVDFYA | 
    100:
    RFSPSPLSMK | QFLDFGSVNA | CEKTSFMFLR | QELPVRLANI | MKEISLLPDN | 
    150:
    LLRTPSVQLV | QSWYIQSLQE | LLDFKDKSAE | DAKAIYDFTD | TVIRIRNRHN | 
    200:
    DVIPTMAQGV | IEYKESFGVD | PVTSQNVQYF | LDRFYMSRIS | IRMLLNQHSL | 
    250:
    LFGGKGKGSP | SHRKHIGSIN | PNCNVLEVIK | DGYENARRLC | DLYYINSPEL | 
    300:
    ELEELNAKSP | GQPIQVVYVP | SHLYHMVFEL | FKNAMRATME | HHANRGVYPP | 
    350:
    IQVHVTLGNE | DLTVKMSDRG | GGVPLRKIDR | LFNYMYSTAP | RPRVETSRAV | 
    400:
    PLAGFGYGLP | ISRLYAQYFQ | GDLKLYSLEG | YGTDAVIYIK | ALSTDSIERL | 
    436:
    PVYNKAAWKH | YNTNHEADDW | CVPSREPKDM | TTFRSA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    E10511r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    E10511h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    E10511m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    U10511h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    U10511r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    U10511m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Cat.:
    P10511Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Polyclonal Antibody for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Monoclonal Antibody for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Monoclonal Antibody for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Monoclonal Antibody for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Protein for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Protein for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
    Protein for Human [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Diversity of the pyruvate dehydrogenase kinase gene family in humans."
      Gudi R. , Bowker-Kinley M.M. , Kedishvili N.Y. , Zhao Y. , Popov K.M.
      J. Biol. Chem.270:28989-28994(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      Li H. , Nong W. , Zhou G. , Ke R. , Shen C. , Zhong G. , Zheng Z. , Liang M. , Tang Z. , Huang B. , Lin L. , Yang S.
      Submitted (2005-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    7. 7.
      "Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells."
      McFate T. , Mohyeldin A. , Lu H. , Thakar J. , Henriques J. , Halim N.D. , Wu H. , Schell M.J. , Tsang T.M. , Teahan O. , Zhou S. , Califano J.A. , Jeoung N.H. , Harris R.A. , Verma A.
      J. Biol. Chem.283:22700-22708(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer."
      Lu C.W. , Lin S.C. , Chien C.W. , Lin S.C. , Lee C.T. , Lin B.W. , Lee J.C. , Tsai S.J.
      Am. J. Pathol.179:1405-1414(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY HYPOXIA
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism."
      Hitosugi T. , Fan J. , Chung T.W. , Lythgoe K. , Wang X. , Xie J. , Ge Q. , Gu T.L. , Polakiewicz R.D. , Roesel J.L. , Chen G.Z. , Boggon T.J. , Lonial S. , Fu H. , Khuri F.R. , Kang S. , Chen J.
      Mol. Cell44:864-877(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-136; TYR-243 AND TYR-244
    11. 11.
      "Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol."
      Kato M. , Li J. , Chuang J.L. , Chuang D.T.
      Structure15:992-1004(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 30-436 IN COMPLEX WITH THE INHIBITORS AZD7545 AND DICHLOROACETATE;FUNCTION;SUBUNIT;CATALYTIC ACTIVITY;ENZYME REGULATION
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