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Index > Protein center > PECAM1(Gene name) > Human
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  • PECAM1 (Gene name),
  • Platelet endothelial cell adhesion molecule (Protein name ),  PECA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PECAM1;
    Protein name:
    Platelet endothelial cell adhesion molecule(PECAM-1);
    Alternative:
    PECA1;EndoCAM;GPIIA';
    CD:
    CD31;
    Organism:
    PECAM1 (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.
    Function:
    Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
    Subcellular Location:
    Isoform Delta15 Cell junction Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
    Protein Attributes:
    Sequence length:
    738
    Sequence:
    50:
    MQPRWAQGAT | MWLGVLLTLL | LCSSLEGQEN | SFTINSVDMK | SLPDWTVQNG | 
    100:
    KNLTLQCFAD | VSTTSHVKPQ | HQMLFYKDDV | LFYNISSMKS | TESYFIPEVR | 
    150:
    IYDSGTYKCT | VIVNNKEKTT | AEYQLLVEGV | PSPRVTLDKK | EAIQGGIVRV | 
    200:
    NCSVPEEKAP | IHFTIEKLEL | NEKMVKLKRE | KNSRDQNFVI | LEFPVEEQDR | 
    250:
    VLSFRCQARI | ISGIHMQTSE | STKSELVTVT | ESFSTPKFHI | SPTGMIMEGA | 
    300:
    QLHIKCTIQV | THLAQEFPEI | IIQKDKAIVA | HNRHGNKAVY | SVMAMVEHSG | 
    350:
    NYTCKVESSR | ISKVSSIVVN | ITELFSKPEL | ESSFTHLDQG | ERLNLSCSIP | 
    400:
    GAPPANFTIQ | KEDTIVSQTQ | DFTKIASKSD | SGTYICTAGI | DKVVKKSNTV | 
    450:
    QIVVCEMLSQ | PRISYDAQFE | VIKGQTIEVR | CESISGTLPI | SYQLLKTSKV | 
    500:
    LENSTKNSND | PAVFKDNPTE | DVEYQCVADN | CHSHAKMLSE | VLRVKVIAPV | 
    550:
    DEVQISILSS | KVVESGEDIV | LQCAVNEGSG | PITYKFYREK | EGKPFYQMTS | 
    600:
    NATQAFWTKQ | KASKEQEGEY | YCTAFNRANH | ASSVPRSKIL | TVRVILAPWK | 
    650:
    KGLIAVVIIG | VIIALLIIAA | KCYFLRKAKA | KQMPVEMSRP | AVPLLNSNNE | 
    700:
    KMSDPNMEAN | SHYGHNDDVR | NHAMKPINDN | KEPLNSDVQY | TEVQVSSAES | 
    738:
    HKDLGKKDTE | TVYSEVRKAV | PDAVESRYSR | TEGSLDGT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human PECAM-1
    Cat.:
    E0363h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PECAM-1
    Cat.:
    E0363r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PECAM-1
    Cat.:
    E0363p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PECAM-1
    Cat.:
    E0363b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PECAM-1
    Cat.:
    E0363m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PECAM-1
    Cat.:
    U0363m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PECAM-1
    Cat.:
    U0363r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PECAM-1
    Cat.:
    U0363h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PECAM-1
    Cat.:
    U0363p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PECAM-1
    Cat.:
    U0363b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PECAM-1
    Cat.:
    P0363Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PECAM-1
    Polyclonal Antibody for Human PECAM-1
    Cat.:
    P0363Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PECAM-1
    Polyclonal Antibody for Human PECAM-1
    Cat.:
    P0363Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PECAM-1
    Monoclonal Antibody for Human PECAM-1
    Monoclonal Antibody for Human PECAM-1
    Monoclonal Antibody for Human PECAM-1
    Monoclonal Antibody for Human PECAM-1
    Protein for Human PECAM-1
    Protein for Human PECAM-1
    Protein for Human PECAM-1
    Protein for Human PECAM-1
    Protein for Human PECAM-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen."
      Simmons D.L. , Walker C. , Power C. , Pigott R.
      J. Exp. Med.171:2147-2152(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    2. 2.
      "Molecular characterization and functional analysis of the leukocyte surface protein CD31."
      Stockinger H. , Gadd S.J. , Eher R. , Majdic O. , Kasinrek W. , Schreiber W. , Strass B. , Schnabl E. , Knapp W.
      J. Immunol.145:3889-3897(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANTS VAL-125; ASN-563 AND GLY-670
    3. 3.
      "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily."
      Newman P.J. , Berndt M.C. , Gorski J. , White J.C. II , Lyman S. , Paddock C. , Muller W.A.
      Science247:1219-1222(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    4. 4.
      "Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule."
      Albelda S.M. , Muller W.A. , Buck C.A. , Newman P.J.
      J. Cell Biol.114:1059-1068(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    5. 5.
      "Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain."
      Kirschbaum N.E. , Gumina R.J. , Newman P.J.
      Blood84:4028-4037(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG);VARIANT ASN-563
    6. 6.
      "Gene cloning and sequence analysis of human nasopharyngeal carcinoma resistance cells CNE1/R platelet/endothelial cell adhesion molecule."
      Wang R.-Y. , Lun Y.-Z. , Jiang Z.-X. , Li X.
      Submitted (2011-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANTS VAL-125; ASN-563 AND GLY-670
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANTS VAL-125; ASN-563 AND GLY-670
      tissue: Lung.
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS VAL-125; ASN-563 AND GLY-670
    9. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANTS VAL-125; ASN-563 AND GLY-670
      tissue: Brain.
    10. 11.
      Robbins F.-M.Y. , Yao H. , Hurley C.K. , Hartzman R.J.
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-734 (ISOFORM LONG);VARIANTS VAL-125; ASN-563 AND GLY-670
    11. 12.
      "Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium."
      Tang D.G. , Chen Y.Q. , Newman P.J. , Shi L. , Gao X. , Diglio C.A. , Honn K.V.
      J. Biol. Chem.268:22883-22894(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 507-584
    12. 13.
      "Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity."
      Famiglietti J. , Sun J. , DeLisser H.M. , Albelda S.M.
      J. Cell Biol.138:1425-1435(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-713
    13. 14.
      "Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment."
      Brown S. , Heinisch I. , Ross E. , Shaw K. , Buckley C.D. , Savill J.
      Nature418:200-203(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 15.
      "Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms."
      Wang Y. , Su X. , Sorenson C.M. , Sheibani N.
      Am. J. Physiol.284:H1008-H1017(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    15. 16.
      "Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection."
      Sardjono C.T. , Harbour S.N. , Yip J.C. , Paddock C. , Tridandapani S. , Newman P.J. , Jackson D.E.
      Thromb. Haemost.96:756-766(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-622;MUTAGENESIS OF CYS-622
    16. 17.
      "Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1."
      Yeh J.C. , Otte L.A. , Frangos J.A.
      Biochemistry47:9029-9039(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BDKRB2 AND GNAQ
    17. 18.
      "Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation."
      Chiu Y.J. , McBeath E. , Fujiwara K.
      J. Cell Biol.182:753-763(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    18. 19.
      "An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling."
      Bergom C. , Paddock C. , Gao C. , Holyst T. , Newman D.K. , Newman P.J.
      J. Cell Sci.121:1235-1242(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS DELTA14-15 AND DELTA15);FUNCTION (ISOFORM DELTA15);SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-690 AND TYR-713;INTERACTION WITH PTPN11
    19. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    20. 21.
      "A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration."
      Dasgupta B. , Dufour E. , Mamdouh Z. , Muller W.A.
      J. Immunol.182:5041-5051(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION AT TYR-690 AND TYR-713;MUTAGENESIS OF LYS-89; TYR-690 AND TYR-713;INTERACTION WITH PTPN11
    21. 22.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-151; ASN-320 AND ASN-453
      tissue: Liver.
    22. 23.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-320 AND ASN-551
      tissue: Leukemic T-cell.
    23. 24.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    24. 25.
      "Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases."
      Marin E.P. , Derakhshan B. , Lam T.T. , Davalos A. , Sessa W.C.
      Circ. Res.110:1336-1344(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION BY ZDHHC21;SUBCELLULAR LOCATION
    25. 26.
      "Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease."
      Behar E. , Chao N.J. , Hiraki D.D. , Krishnaswamy S. , Brown B.W. , Zehnder J.L. , Grumet F.C.
      N. Engl. J. Med.334:286-291(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-125
    26. 27.
      "Codon 125 polymorphism of CD31 and susceptibility to malaria."
      Casals-Pascual C. , Allen S. , Allen A. , Kai O. , Lowe B. , Pain A. , Roberts D.J.
      Am. J. Trop. Med. Hyg.65:736-737(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-125
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