SERPINF1 ELISA Kit for Human(Homo sapiens) | EIAab.comSERPINF1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SERPINF1(Gene name) > Human

SERPINF1 (Gene name),

Pigment epithelium-derived factor (Protein name ), PEDF_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SERPINF1(PIG35;PEDF);

Protein name:

Pigment epithelium-derived factor(PEDF);

Alternative:

EPC-1;Cell proliferation-inducing gene 35 protein;Serpin F1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Subcellular Location:

Secreted Melanosome Enriched in stage I melanosomes.

Protein Attributes:

Sequence length:

418

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

418:

TDTGALLFIG | KILDPRGP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.532768

MIM:

172860

KEGG:

hsa:5176

String:

P36955

Pfam:

PF00079

SMR:

P36955

STRING:

9606.ENSP00000254722

Uniprot:

P36955

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ELISA Kit for Human PEDF

Cat.:

E0784h

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Manual:

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Packing:

96T

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ELISA Kit for Human PEDF

Cat.:

E0784m

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Packing:

96T

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ELISA Kit for Human PEDF

Cat.:

E0784b

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96T

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ELISA Kit for Human PEDF

Cat.:

E0784r

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MSDS:

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Packing:

96T

CLIA Kit for Human PEDF

Cat.:

U0784m

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Manual:

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96T

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CLIA Kit for Human PEDF

Cat.:

U0784r

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MSDS:

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Packing:

96T

CLIA Kit for Human PEDF

Cat.:

U0784h

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MSDS:

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Packing:

96T

CLIA Kit for Human PEDF

Cat.:

U0784b

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Packing:

96T

Polyclonal Antibody for Human PEDF

Cat.:

P0784Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PEDF

Cat.:

P0784Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PEDF

Cat.:

P0784Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PEDF

Protein for Human PEDF

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family."
Steele F.R. , Chader G.J. , Johnson L.V. , Tombran-Tink J.
Proc. Natl. Acad. Sci. U.S.A.90:1526-1530(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT MET-72
tissue: Fetal eye.
2.

"Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin."
Tombran-Tink J. , Mazuruk K. , Rodriguez I.R. , Chung D. , Linker T. , Englander E. , Chader G.J.
Mol. Vis.2:11-11(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-72
3.

Yin B. , Peng X. , Yuan J. , Qiang B.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT MET-72
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Identification of a human cell proliferation inducing gene."
Kim J.W.
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-72
tissue: Liver cancer.
6.

"Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
Oshikawa M. , Tsutsui C. , Ikegami T. , Fuchida Y. , Matsubara M. , Toyama S. , Usami R. , Ohtoko K. , Kato S.
Invest. Ophthalmol. Vis. Sci.52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT MET-72
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS MET-72 AND ARG-132
tissue: Muscle.
10.

Coljee V.W.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-332;VARIANT MET-72
tissue: Fetal lung fibroblast.
11.

"Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization."
Petersen S.V. , Valnickova Z. , Enghild J.J.
Biochem. J.374:199-206(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-29; 253-262 AND 282-303;TISSUE SPECIFICITY;PYROGLUTAMATE FORMATION AT GLN-20
tissue: Plasma.
12.

"Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."
Pignolo R.J. , Cristofalo V.J. , Rotenberg M.O.
J. Biol. Chem.268:8949-8957(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-418;VARIANT MET-72
tissue: Fetal lung fibroblast.
13.

"Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor."
Becerra S.P. , Palmer I. , Kumar A. , Steele F.R. , Shiloach J. , Notario V. , Chader G.J.
J. Biol. Chem.268:23148-23156(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop."
Becerra S.P. , Sagasti A. , Spinella P. , Notario V.
J. Biol. Chem.270:25992-25999(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor."
Maik-Rachline G. , Shaltiel S. , Seger R.
Blood105:670-678(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-24; SER-114 AND SER-227
16.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285
tissue: Plasma.
17.

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Melanoma.
18.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285
tissue: Liver.
19.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-285
20.

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS];STRUCTURE OF CARBOHYDRATES
tissue: Cerebrospinal fluid.
21.

"Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta."
Becker J. , Semler O. , Gilissen C. , Li Y. , Bolz H.J. , Giunta C. , Bergmann C. , Rohrbach M. , Koerber F. , Zimmermann K. , de Vries P. , Wirth B. , Schoenau E. , Wollnik B. , Veltman J.A. , Hoischen A. , Netzer C.
Am. J. Hum. Genet.88:362-371(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN OI6
22.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor."
Simonovic M. , Gettins P.G.W. , Volz K.
Proc. Natl. Acad. Sci. U.S.A.98:11131-11135(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 21-418;GLYCOSYLATION AT ASN-285
24.

"Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis."
Koenekoop R. , Pina A.L. , Loyer M. , Davidson J. , Robitaille J. , Maumenee I. , Tombran-Tink J.
Mol. Vis.5:10-10(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-72
25.

"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-72;IDENTIFICATION BY MASS SPECTROMETRY

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