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Index > Protein center > SERPINF1(Gene name) > Human
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  • SERPINF1 (Gene name),
  • Pigment epithelium-derived factor (Protein name ),  PEDF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    SERPINF1(PIG35;PEDF);
    Protein name:
    Pigment epithelium-derived factor(PEDF);
    Alternative:
    EPC-1;Cell proliferation-inducing gene 35 protein;Serpin F1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
    Subcellular Location:
    Secreted Melanosome Enriched in stage I melanosomes.
    Protein Attributes:
    Sequence length:
    418
    Sequence:
    50:
    MQALVLLLCI | GALLGHSSCQ | NPASPPEEGS | PDPDSTGALV | EEEDPFFKVP | 
    100:
    VNKLAAAVSN | FGYDLYRVRS | STSPTTNVLL | SPLSVATALS | ALSLGAEQRT | 
    150:
    ESIIHRALYY | DLISSPDIHG | TYKELLDTVT | APQKNLKSAS | RIVFEKKLRI | 
    200:
    KSSFVAPLEK | SYGTRPRVLT | GNPRLDLQEI | NNWVQAQMKG | KLARSTKEIP | 
    250:
    DEISILLLGV | AHFKGQWVTK | FDSRKTSLED | FYLDEERTVR | VPMMSDPKAV | 
    300:
    LRYGLDSDLS | CKIAQLPLTG | SMSIIFFLPL | KVTQNLTLIE | ESLTSEFIHD | 
    350:
    IDRELKTVQA | VLTVPKLKLS | YEGEVTKSLQ | EMKLQSLFDS | PDFSKITGKP | 
    400:
    IKLTQVEHRA | GFEWNEDGAG | TTPSPGLQPA | HLTFPLDYHL | NQPFIFVLRD | 
    418:
    TDTGALLFIG | KILDPRGP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    String:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human PEDF
    Cat.:
    E0784h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PEDF
    Cat.:
    E0784m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PEDF
    Cat.:
    E0784b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PEDF
    Cat.:
    E0784r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PEDF
    Cat.:
    U0784m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PEDF
    Cat.:
    U0784r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PEDF
    Cat.:
    U0784h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PEDF
    Cat.:
    U0784b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PEDF
    Cat.:
    P0784Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PEDF
    Cat.:
    P0784Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PEDF
    Polyclonal Antibody for Human PEDF
    Cat.:
    P0784Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PEDF
    Monoclonal Antibody for Human PEDF
    Monoclonal Antibody for Human PEDF
    Monoclonal Antibody for Human PEDF
    Protein for Human PEDF
    Protein for Human PEDF
    Protein for Human PEDF
    Protein for Human PEDF

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    References
    1. 1.
      "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family."
      Steele F.R. , Chader G.J. , Johnson L.V. , Tombran-Tink J.
      Proc. Natl. Acad. Sci. U.S.A.90:1526-1530(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT MET-72
      tissue: Fetal eye.
    2. 2.
      "Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin."
      Tombran-Tink J. , Mazuruk K. , Rodriguez I.R. , Chung D. , Linker T. , Englander E. , Chader G.J.
      Mol. Vis.2:11-11(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-72
    3. 3.
      Yin B. , Peng X. , Yuan J. , Qiang B.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT MET-72
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Identification of a human cell proliferation inducing gene."
      Kim J.W.
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-72
      tissue: Liver cancer.
    6. 6.
      "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
      Oshikawa M. , Tsutsui C. , Ikegami T. , Fuchida Y. , Matsubara M. , Toyama S. , Usami R. , Ohtoko K. , Kato S.
      Invest. Ophthalmol. Vis. Sci.52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT MET-72
    8. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS MET-72 AND ARG-132
      tissue: Muscle.
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-332;VARIANT MET-72
      tissue: Fetal lung fibroblast.
    10. 11.
      "Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization."
      Petersen S.V. , Valnickova Z. , Enghild J.J.
      Biochem. J.374:199-206(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-29; 253-262 AND 282-303;TISSUE SPECIFICITY;PYROGLUTAMATE FORMATION AT GLN-20
      tissue: Plasma.
    11. 12.
      "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state."
      Pignolo R.J. , Cristofalo V.J. , Rotenberg M.O.
      J. Biol. Chem.268:8949-8957(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-418;VARIANT MET-72
      tissue: Fetal lung fibroblast.
    12. 13.
      "Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor."
      Becerra S.P. , Palmer I. , Kumar A. , Steele F.R. , Shiloach J. , Notario V. , Chader G.J.
      J. Biol. Chem.268:23148-23156(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 14.
      "Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop."
      Becerra S.P. , Sagasti A. , Spinella P. , Notario V.
      J. Biol. Chem.270:25992-25999(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 15.
      "Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor."
      Maik-Rachline G. , Shaltiel S. , Seger R.
      Blood105:670-678(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-24; SER-114 AND SER-227
    15. 16.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285
      tissue: Plasma.
    16. 17.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    17. 18.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-285
      tissue: Liver.
    18. 19.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-285
    19. 20.
      "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
      Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS];STRUCTURE OF CARBOHYDRATES
      tissue: Cerebrospinal fluid.
    20. 21.
      "Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive osteogenesis imperfecta."
      Becker J. , Semler O. , Gilissen C. , Li Y. , Bolz H.J. , Giunta C. , Bergmann C. , Rohrbach M. , Koerber F. , Zimmermann K. , de Vries P. , Wirth B. , Schoenau E. , Wollnik B. , Veltman J.A. , Hoischen A. , Netzer C.
      Am. J. Hum. Genet.88:362-371(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN OI6
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 23.
      "Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor."
      Simonovic M. , Gettins P.G.W. , Volz K.
      Proc. Natl. Acad. Sci. U.S.A.98:11131-11135(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 21-418;GLYCOSYLATION AT ASN-285
    23. 24.
      "Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis."
      Koenekoop R. , Pina A.L. , Loyer M. , Davidson J. , Robitaille J. , Maumenee I. , Tombran-Tink J.
      Mol. Vis.5:10-10(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-72
    24. 25.
      "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
      Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
      J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-72;IDENTIFICATION BY MASS SPECTROMETRY
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