PSENEN ELISA Kit for Human(Homo sapiens) | EIAab.comPSENEN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PSENEN(Gene name) > Human

PSENEN (Gene name),

Gamma-secretase subunit PEN-2 (Protein name ), PEN2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PSENEN(MDS033;PEN2);

Protein name:

Gamma-secretase subunit PEN-2;

Alternative:

Presenilin enhancer protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist.

Function:

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus Golgi stack membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

Protein Attributes:

Sequence length:

101

Sequence:

50:

100:

101:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9NZ42

MIM:

607632

UniGene:

Hs.534465

KEGG:

hsa:55851

STRING:

9606.ENSP00000222266

Pfam:

PF10251

Uniprot:

Q9NZ42

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ELISA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

E3143h

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MSDS:

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Packing:

96T

ELISA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

E3143m

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Manual:

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Packing:

96T

Range:

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ELISA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

E3143r

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MSDS:

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Packing:

96T

ELISA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

E3143b

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Packing:

96T

CLIA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

U3143r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

U3143b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

U3143h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Gamma-secretase subunit PEN-2

Cat.:

U3143m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Gamma-secretase subunit PEN-2

Cat.:

P3143Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gamma-secretase subunit PEN-2

Cat.:

P3143Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gamma-secretase subunit PEN-2

Monoclonal Antibody for Human Gamma-secretase subunit PEN-2

Protein for Human Gamma-secretase subunit PEN-2

Cat.:

R3143h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human Gamma-secretase subunit PEN-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Zhao M. , Gu J. , Li N. , Peng Y. , Han Z. , Chen Z.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Hematopoietic stem cell.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Uterus.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
4.

"PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin."
Steiner H. , Winkler E. , Edbauer D. , Prokop S. , Basset G. , Yamasaki A. , Kostka M. , Haass C.
J. Biol. Chem.277:39062-39065(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCSTN; PSEN1 AND PSEN2
5.

"aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation."
Francis R. , McGrath G. , Zhang J. , Ruddy D.A. , Sym M. , Apfeld J. , Nicoll M. , Maxwell M. , Hai B. , Ellis M.C. , Parks A.L. , Xu W. , Li J. , Gurney M. , Myers R.L. , Himes C.S. , Hiebsch R. , Ruble C. , more...
Dev. Cell3:85-97(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1."
Luo W.-J. , Wang H. , Li H. , Kim B.S. , Shah S. , Lee H.-J. , Thinakaran G. , Kim T.-W. , Yu G. , Xu H.
J. Biol. Chem.278:7850-7854(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
7.

"Membrane topology of gamma-secretase component PEN-2."
Crystal A.S. , Morais V.A. , Pierson T.C. , Pijak D.S. , Carlin D. , Lee V.M. , Doms R.W.
J. Biol. Chem.278:20117-20123(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MEMBRANE TOPOLOGY;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-10; ALA-46 AND SER-93
8.

"APH1, PEN2, and nicastrin increase Abeta levels and gamma-secretase activity."
Marlow L. , Canet R.M. , Haugabook S.J. , Hardy J.A. , Lahiri D.K. , Sambamurti K.
Biochem. Biophys. Res. Commun.305:502-509(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE GAMMA-SECRETASE COMPLEX
9.

"Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2."
Kimberly W.T. , LaVoie M.J. , Ostaszewski B.L. , Ye W. , Wolfe M.S. , Selkoe D.J.
Proc. Natl. Acad. Sci. U.S.A.100:6382-6387(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;COMPONENT OF A GAMMA-SECRETASE COMPLEX WITH APH1A; PSEN1/PSEN2 AND NCSTN
10.

"Reconstitution of gamma-secretase activity."
Edbauer D. , Winkler E. , Regula J.T. , Pesold B. , Steiner H. , Haass C.
Nat. Cell Biol.5:486-488(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME ACTIVITY OF A GAMMA-SECRETASE COMPLEX
11.

"Gamma-secretase gene mutations in familial acne inversa."
Wang B. , Yang W. , Wen W. , Sun J. , Su B. , Liu B. , Ma D. , Lv D. , Wen Y. , Qu T. , Chen M. , Sun M. , Shen Y. , Zhang X.
Science330:1065-1065(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ACNINV2

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