HSPG2 ELISA Kit for Human(Homo sapiens) | EIAab.comHSPG2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HSPG2(Gene name) > Human

HSPG2 (Gene name),

Basement membrane-specific heparan sulfate proteoglycan core protein (Protein name ), PGBM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HSPG2;

Protein name:

Basement membrane-specific heparan sulfate proteoglycan core protein(HSPG);

Alternative:

Perlecan(PLC);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other basement membrane components such as laminin, prolargin and collagen type IV. Interacts with COL13A1, FGFBP1 and VWA1. Interacts (via C-terminus) with ECM1 (via C-terminus).

Function:

The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

Subcellular Location:

Secreted extracellular space extracellular matrix basement membrane

Protein Attributes:

Sequence length:

4391

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4391:

GITGCVKNLV | LHSARPGAPP | PQPLDLQHRA | QAGANTRPCP | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P98160

Pfam:

PF00008

KEGG:

hsa:3339

STRING:

9606.ENSP00000363827

UniGene:

Hs.562227

String:

P98160

MIM:

142461

Uniprot:

P98160

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ELISA Kit for Human HSPG

Cat.:

E0565m

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Manual:

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Packing:

96T

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ELISA Kit for Human HSPG

Cat.:

E0565h

Price:

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Manual:

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Packing:

96T

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CLIA Kit for Human HSPG

Cat.:

U0565m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human HSPG

Cat.:

U0565h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human HSPG

Cat.:

P0565Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human HSPG

Cat.:

P0565Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human HSPG

Protein for Human HSPG

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor."
Murdoch A.D. , Dodge G.R. , Cohen I. , Tuan R.S. , Iozzo R.V.
J. Biol. Chem.267:8544-8557(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-638; SER-765 AND VAL-1503
tissue: Colon.
tissue: Skin.
2.

"Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor."
Kallunki P. , Tryggvason K.
J. Cell Biol.116:559-571(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-638; SER-765; VAL-1503; HIS-2980; GLY-2995; THR-3168 AND GLN-3632
3.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Structural characterization of the complete human perlecan gene and its promoter."
Cohen I.R. , Graessel S. , Murdoch A.D. , Iozzo R.V.
Proc. Natl. Acad. Sci. U.S.A.90:10404-10408(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21
5.

"Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia)."
Nicole S. , Davoine C.-S. , Topaloglu H. , Cattolico L. , Barral D. , Beighton P. , Ben-Hamida C. , Hammouda H. , Cruaud C. , White P.S. , Samson D. , Urtizberea J.A. , Lehmann-Horn F. , Weissenbach J. , Hentati F. , Fontaine B.
Nat. Genet.26:480-483(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-4391;VARIANTS VAL-638 AND SJS1 TYR-1532;VARIANTS SER-765 AND VAL-1503
6.

"Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1-->p35 and identification of a BamHI restriction fragment length polymorphism."
Kallunki P. , Eddy R.L. , Byers M.G. , Kestila M. , Shows T.B. , Tryggvason K.
Genomics11:389-396(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 890-1396
tissue: Fibrosarcoma.
7.

"Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1."
Dodge G.R. , Kovalszky I. , Chu M.-L. , Hassell J.R. , McBride O.W. , Yi H.F. , Iozzo R.V.
Genomics10:673-680(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1016-1470
tissue: Colon.
8.

"Matrix-associated heparan sulfate proteoglycan: core protein-specific monoclonal antibodies decorate the pericellular matrix of connective tissue cells and the stromal side of basement membranes."
Heremans A. , van der Schueren B. , de Cock B. , Paulsson M. , Cassiman J.-J. , van den Berghe H. , David G.
J. Cell Biol.109:3199-3211(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1379-1398 AND 2259-2278
9.

"BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan."
Gonzalez E.M. , Reed C.C. , Bix G. , Fu J. , Zhang Y. , Gopalakrishnan B. , Greenspan D.S. , Iozzo R.V.
J. Biol. Chem.280:7080-7087(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4197-4208;PROTEOLYTIC PROCESSING AT ASN-4196;FUNCTION OF LG3 PEPTIDE;GLYCOSYLATION;MUTAGENESIS OF ASP-4197; ASP-4258 AND ASN-4327
10.

"Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan."
Mongiat M. , Sweeney S.M. , San Antonio J.D. , Fu J. , Iozzo R.V.
J. Biol. Chem.278:4238-4249(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4197-4203;PROTEOLYTIC PROCESSING AT ASN-4196;FUNCTION OF ENDOREPELLIN AND LG3 PEPTIDE
11.

"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core."
Mongiat M. , Otto J. , Oldershaw R. , Ferrer F. , Sato J.D. , Iozzo R.V.
J. Biol. Chem.276:10263-10271(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFBP1
12.

"Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene."
Arikawa-Hirasawa E. , Wilcox W.R. , Le A.H. , Silverman N. , Govindraj P. , Hassell J.R. , Yamada Y.
Nat. Genet.27:431-434(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DDSH
13.

"The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin."
Tu H. , Sasaki T. , Snellman A. , Gohring W. , Pirila P. , Timpl R. , Pihlajaniemi T.
J. Biol. Chem.277:23092-23099(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COL13A1
14.

"Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis."
Mongiat M. , Fu J. , Oldershaw R. , Greenhalgh R. , Gown A.M. , Iozzo R.V.
J. Biol. Chem.278:17491-17499(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ECM1
15.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-2121
16.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1755
tissue: Plasma.
17.

"Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism."
Bix G. , Castello R. , Burrows M. , Zoeller J.J. , Weech M. , Iozzo R.A. , Cardi C. , Thakur M.L. , Barker C.A. , Camphausen K. , Iozzo R.V.
J. Natl. Cancer Inst.98:1634-1646(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF ENDOREPELLIN
18.

"Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity."
Woodall B.P. , Nystroem A. , Iozzo R.A. , Eble J.A. , Niland S. , Krieg T. , Eckes B. , Pozzi A. , Iozzo R.V.
J. Biol. Chem.283:2335-2343(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF ENDOREPELLIN;IDENTIFICATION OF RECEPTOR
19.

"Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity."
Nystrom A. , Shaik Z.P. , Gullberg D. , Krieg T. , Eckes B. , Zent R. , Pozzi A. , Iozzo R.V.
Blood114:4897-4906(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-554; ASN-1755; ASN-3072; ASN-3780; ASN-3836 AND ASN-4068
tissue: Liver.
21.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-42;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
22.

"Crystal structure of the LG3 domain of endorepellin, an angiogenesis inhibitor."
Le B.V. , Kim H. , Choi J. , Kim J.H. , Hahn M.J. , Lee C. , Kim K.K. , Hwang H.Y.
J. Mol. Biol.414:231-242(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 4197-4391;DISULFIDE BOND;CALCIUM-BINDING SITES

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