ACAN ELISA Kit for Human(Homo sapiens) | EIAab.comACAN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ACAN(Gene name) > Human

ACAN (Gene name),

Aggrecan core protein (Protein name ), PGCA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

ACAN(AGC1;CSPG1;MSK16);

Protein name:

Aggrecan core protein;

Alternative:

Chondroitin sulfate proteoglycan core protein 1(Chondroitin sulfate proteoglycan 1);Cartilage-specific proteoglycan core protein(CSPCP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with FBLN1 (By similarity). Interacts with COMP.

Function:

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

2415

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2415:

RSSRHPRRSR | PSTAH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.2159

Pfam:

PF00008

SMR:

P16112

STRING:

9606.ENSP00000268134

MIM:

155760

String:

P16112

Uniprot:

P16112

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ELISA Kit for Human Aggrecan core protein

Cat.:

E1908h

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ELISA Kit for Human Aggrecan core protein

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ELISA Kit for Human Aggrecan core protein

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E1908d

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ELISA Kit for Human Aggrecan core protein

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E1908m

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ELISA Kit for Human Aggrecan core protein

Cat.:

E1908c

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96T

ELISA Kit for Human Aggrecan core protein

Cat.:

E1908b

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96T

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ELISA Kit for Human Aggrecan core protein

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E1908p

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ELISA Kit for Human Aggrecan core protein

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CLIA Kit for Human Aggrecan core protein

Cat.:

U1908r

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96T

CLIA Kit for Human Aggrecan core protein

Cat.:

U1908p

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96T

CLIA Kit for Human Aggrecan core protein

Cat.:

U1908c

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96T

CLIA Kit for Human Aggrecan core protein

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CLIA Kit for Human Aggrecan core protein

Cat.:

U1908m

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Looking for manual.

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96T

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CLIA Kit for Human Aggrecan core protein

Cat.:

U1908d

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human Aggrecan core protein

Cat.:

U1908h

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Looking for manual.

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96T

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CLIA Kit for Human Aggrecan core protein

Cat.:

U1908b

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96T

Polyclonal Antibody for Human Aggrecan core protein

Cat.:

P1908Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Aggrecan core protein

Cat.:

P1908Rb-h

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Polyclonal Antibody for Human Aggrecan core protein

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P1908Rb-m

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Polyclonal Antibody for Human Aggrecan core protein

Monoclonal Antibody for Human Aggrecan core protein

Protein for Human Aggrecan core protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Overexpression of hTERT extends replicative capacity of human nucleus pulposus cells, and protects against serum starvation-induced apoptosis and..."

W Liang, D Ye, L Dai, et al.

From:Journal of Cellular Biochemistry

References

1.

"Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms."
Doege K.J. , Sasaki M. , Kimura T. , Yamada Y.
J. Biol. Chem.266:894-902(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Chondrocyte.
2.

"Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid."
Ilic M.Z. , Mok M.T. , Williamson O.D. , Campbell M.A. , Hughes C.E. , Handley C.J.
Arch. Biochem. Biophys.322:22-30(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-27 AND 393-403;PROTEOLYTIC PROCESSING BY AGGRECANASE
3.

"The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain."
Sandy J.D. , Flannery C.R. , Neame P.J. , Lohmander L.S.
J. Clin. Invest.89:1512-1516(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 361-373 AND 393-409;PROTEOLYTIC PROCESSING;GLYCOSYLATION AT THR-371 AND THR-376
4.

"Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."
Glumoff V. , Savontaus M. , Vehanen J. , Vuorio E.
Biochim. Biophys. Acta1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 380-497;TISSUE SPECIFICITY
5.

"The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis."
Lohmander L.S. , Neame P.J. , Sandy J.D.
Arthritis Rheum.36:1214-1222(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 393-409
tissue: Synovial fluid.
6.

"Length variation in the keratan sulfate domain of mammalian aggrecan."
Barry F.P. , Neame P.J. , Sasse J. , Pearson D.
Matrix Biol.14:323-328(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 764-864
tissue: Blood.
7.

"Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage."
Dudhia J. , Davidson C.M. , Wells T.M. , Vynios D.H. , Hardingham T.E. , Bayliss M.T.
Biochem. J.313:933-940(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1778-2415 (ISOFORM 2)
tissue: Chondrocyte.
8.

"A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain."
Baldwin C.T. , Reginato A.M. , Prockop D.J.
J. Biol. Chem.264:15747-15750(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1936-2415 (ISOFORM 1)
9.

"A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis."
Gleghorn L. , Ramesar R. , Beighton P. , Wallis G.
Am. J. Hum. Genet.77:484-490(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SEDK
10.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-657
tissue: Plasma.
11.

"Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan."
Chen F.-H. , Herndon M.E. , Patel N. , Hecht J.T. , Tuan R.S. , Lawler J.
J. Biol. Chem.282:24591-24598(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COMP
12.

"A recessive skeletal dysplasia, SEMD aggrecan type, results from a missense mutation affecting the C-type lectin domain of aggrecan."
Tompson S.W. , Merriman B. , Funari V.A. , Fresquet M. , Lachman R.S. , Rimoin D.L. , Nelson S.F. , Briggs M.D. , Cohn D.H. , Krakow D.
Am. J. Hum. Genet.84:72-79(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SEMD-ACAN ASN-2266;CHARACTERIZATION OF VARIANT SEMD-ACAN ASN-2266
13.

"A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans."
Stattin E.L. , Wiklund F. , Lindblom K. , Onnerfjord P. , Jonsson B.A. , Tegner Y. , Sasaki T. , Struglics A. , Lohmander S. , Dahl N. , Heinegard D. , Aspberg A.
Am. J. Hum. Genet.86:126-137(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OD MET-2303;DETECTION OF VARIANT OD MET-2303 BY MASS SPECTROMETRY

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