PDGFRB ELISA Kit for Human(Homo sapiens) | EIAab.comPDGFRB ELISA Kit for Human(Homo sapiens)

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PDGFRB (Gene name),

Beta-type platelet-derived growth factor receptor (Protein name ), PGFRB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

PDGFRB(PDGFR;PDGFR1);

Protein name:

Beta-type platelet-derived growth factor receptor(PDGF-R-beta);

Alternative:

Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1(PDGFR-1);CD140 antigen-like family member B;

CD:

CD140b;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly. Interacts with GRB7 and GRB10.

Function:

Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1106

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1106:

AEDSFL

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000261799

Pfam:

PF07679

String:

P09619

MIM:

131440

KEGG:

hsa:5159

SMR:

P09619

UniGene:

Hs.509067

Uniprot:

P09619

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ELISA Kit for Human PDGF-R-beta

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E2061r

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96T

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ELISA Kit for Human PDGF-R-beta

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E2061m

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96T

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ELISA Kit for Human PDGF-R-beta

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E2061h

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96T

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ELISA Kit for Human PDGF-R-beta

Cat.:

E2061d

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Packing:

96T

CLIA Kit for Human PDGF-R-beta

Cat.:

U2061r

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96T

CLIA Kit for Human PDGF-R-beta

Cat.:

U2061h

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Looking for manual.

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96T

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CLIA Kit for Human PDGF-R-beta

Cat.:

U2061m

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MSDS:

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Packing:

96T

CLIA Kit for Human PDGF-R-beta

Cat.:

U2061d

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96T

Polyclonal Antibody for Human PDGF-R-beta

Cat.:

P2061Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human PDGF-R-beta

Cat.:

P2061Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PDGF-R-beta

Cat.:

P2061Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human PDGF-R-beta

Protein for Human PDGF-R-beta

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class."
Gronwald R.G.K. , Grant F.J. , Haldeman B.A. , Hart C.E. , O'Hara P.J. , Hagen F.S. , Ross R. , Bowen-Pope D.F. , Murray M.J.
Proc. Natl. Acad. Sci. U.S.A.85:3435-3439(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS PDGFB RECEPTOR;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;INTERACTION WITH PDGFB
2.

"cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules."
Claesson-Welsh L. , Eriksson A. , Moren A. , Severinsson L. , Ek B. , Oestman A. , Betsholtz C. , Heldin C.-H.
Mol. Cell. Biol.8:3476-3486(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS PDGFB RECEPTOR;SUBCELLULAR LOCATION;GLYCOSYLATION;AUTOPHOSPHORYLATION;INTERACTION WITH PDGFA AND PDGFB
3.

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
4.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PHE-180
tissue: Brain.
6.

"Integration of proviral DNA into the PDGF beta-receptor gene in HTLV-I-infected T-cells results in a novel tyrosine kinase product with transforming activity."
Chi K.D. , McPhee R.A. , Wagner A.S. , Dietz J.J. , Pantazis P. , Goustin A.S.
Oncogene15:1051-1057(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 548-569
7.

"Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm."
Chmielecki J. , Peifer M. , Viale A. , Hutchinson K. , Giltnane J. , Socci N.D. , Hollis C.J. , Dean R.S. , Yenamandra A. , Jagasia M. , Kim A.S. , Dave U.P. , Thomas R.K. , Pao W.
Genes Chromosomes Cancer51:54-65(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 559-1106 (ISOFORM 1);CHROMOSOMAL TRANSLOCATION WITH CEP85L
8.

"Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes."
Roberts W.M. , Look A.T. , Roussel M.F. , Sherr C.J.
Cell55:655-661(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1046-1106
9.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-47
10.

"Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins."
Kazlauskas A. , Cooper J.A.
Cell58:1121-1133(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-751 AND TYR-857
11.

"Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways."
Matsui T. , Pierce J.H. , Fleming T.P. , Greenberger J.S. , LaRochelle W.J. , Ruggiero M. , Aaronson S.A.
Proc. Natl. Acad. Sci. U.S.A.86:8314-8318(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CELL PROLIFERATION AND CHEMOTAXIS;SUBCELLULAR LOCATION
12.

"Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit."
Kazlauskas A. , Durden D.L. , Cooper J.A.
Cell Regul.2:413-425(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION; ACTIVATION OF PLCG1 AND IN PHOSPHORYLATION OF PLCG1 AND RASA1/GAP;MUTAGENESIS OF TYR-751 AND TYR-857
13.

"Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation."
Kelly J.D. , Haldeman B.A. , Grant F.J. , Murray M.J. , Seifert R.A. , Bowen-Pope D.F. , Cooper J.A. , Kazlauskas A.
J. Biol. Chem.266:8987-8992(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA; PDGFA AND PDGFB;FUNCTION AS RECEPTOR FOR PDGFA AND PDGFB;PHOSPHORYLATION AT TYR-857 AND TYR-751
14.

"Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor."
Sorkin A. , Westermark B. , Heldin C.H. , Claesson-Welsh L.
J. Cell Biol.112:469-478(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR PDGFA AND PDGFB;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-634
15.

"Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo."
Kashishian A. , Kazlauskas A. , Cooper J.A.
EMBO J.11:1373-1382(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY;INTERACTION WITH PIK3R1 AND RASA1;PHOSPHORYLATION AT TYR-740; TYR-751; TYR-771 AND TYR-857;MUTAGENESIS OF LYS-634; TYR-716; TYR-740; TYR-751; TYR-763; TYR-771; TYR-775; TYR-778 AND TYR-857
16.

"Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma."
Ronnstrand L. , Mori S. , Arridsson A.K. , Eriksson A. , Wernstedt C. , Hellman U. , Claesson-Welsh L. , Heldin C.H.
EMBO J.11:3911-3919(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CELL PROLIFERATION AND PHOSPHORYLATION OF PLCG1;INTERACTION WITH PLCG1;PHOSPHORYLATION AT TYR-1009 AND TYR-1021;MUTAGENESIS OF TYR-1009 AND TYR-1021
17.

"Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor."
Mori S. , Heldin C.H. , Claesson-Welsh L.
J. Biol. Chem.267:6429-6434(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEGRADATION
18.

"GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit."
Kazlauskas A. , Kashishian A. , Cooper J.A. , Valius M.
Mol. Cell. Biol.12:2534-2544(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1 AND RASA1;MUTAGENESIS OF TYR-740; TYR-751 AND TYR-771
19.

"Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases."
Mori S. , Ronnstrand L. , Yokote K. , Engstrom A. , Courtneidge S.A. , Claesson-Welsh L. , Heldin C.H.
EMBO J.12:2257-2264(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CELL PROLIFERATION;PHOSPHORYLATION AT TYR-579 AND TYR-581; INTERACTION WITH SRC;CATALYTIC ACTIVITY;MUTAGENESIS OF TYR-579 AND TYR-581
20.

"Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor."
Fretto L.J. , Snape A.J. , Tomlinson J.E. , Seroogy J.J. , Wolf D.L. , LaRochelle W.J. , Giese N.A.
J. Biol. Chem.268:3625-3631(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DGFA AND PDGFB
21.

"Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor."
Lechleider R.J. , Sugimoto S. , Bennett A.M. , Kashishian A.S. , Cooper J.A. , Shoelson S.E. , Walsh C.T. , Neel B.G.
J. Biol. Chem.268:21478-21481(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION AND ACTIVATION OF PTPN11;INTERACTION WITH PTPN11; PIK3R1; PLCG1 AND RASA1;MUTAGENESIS OF TYR-1009
22.

"Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor."
Nishimura R. , Li W. , Kashishian A. , Mondino A. , Zhou M. , Cooper J. , Schlessinger J.
Mol. Cell. Biol.13:6889-6896(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCK1 AND PIK3R1;FUNCTION IN PHOSPHORYLATION OF NCK1;MUTAGENESIS OF TYR-751
23.

"Shb is a ubiquitously expressed Src homology 2 protein."
Welsh M. , Mares J. , Karlsson T. , Lavergne C. , Breant B. , Claesson-Welsh L.
Oncogene9:19-27(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
24.

"Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors."
Yokote K. , Margolis B. , Heldin C.H. , Claesson-Welsh L.
J. Biol. Chem.271:30942-30949(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7
25.

"Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution."
Abe A. , Emi N. , Tanimoto M. , Terasaki H. , Marunouchi T. , Saito H.
Blood90:4271-4277(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TRIP11
26.

"Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis."
Wang J. , Dai H. , Yousaf N. , Moussaif M. , Deng Y. , Boufelliga A. , Swamy O.R. , Leone M.E. , Riedel H.
Mol. Cell. Biol.19:6217-6228(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB10;MUTAGENESIS OF TYR-579; TYR-581; TYR-716; TYR-740; TYR-751; TYR-771; TYR-857; TYR-1009 AND TYR-1021
27.

"APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis."
Yokouchi M. , Wakioka T. , Sakamoto H. , Yasukawa H. , Ohtsuka S. , Sasaki A. , Ohtsubo M. , Valius M. , Inoue A. , Komiya S. , Yoshimura A.
Oncogene18:759-767(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B2/APS
28.

"Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1."
Kovalenko M. , Denner K. , Sandstrom J. , Persson C. , Gross S. , Jandt E. , Vilella R. , Bohmer F. , Ostman A.
J. Biol. Chem.275:16219-16226(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-562; TYR-751; TYR-763; TYR-771; TYR-775; TYR-778; TYR-857; TYR-1009 AND TYR-1021;DEPHOSPHORYLATION AT TYR-751; TYR-857; TYR-1009 AND TYR-1021 BY PTPRJ
29.

"Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors."
Arcaro A. , Zvelebil M.J. , Wallasch C. , Ullrich A. , Waterfield M.D. , Domin J.
Mol. Cell. Biol.20:3817-3830(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3C2B
30.

"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
Gilbertson D.G. , Duff M.E. , West J.W. , Kelly J.D. , Sheppard P.O. , Hofstrand P.D. , Gao Z. , Shoemaker K. , Bukowski T.R. , Moore M. , Feldhaus A.L. , Humes J.M. , Palmer T.E. , Hart C.E.
J. Biol. Chem.276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR PDGFC;INTERACTION WITH PDGFC
31.

"PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor."
Bergsten E. , Uutela M. , Li X. , Pietras K. , Oestman A. , Heldin C.-H. , Alitalo K. , Eriksson U.
Nat. Cell Biol.3:512-516(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR PDGFD
32.

"Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta."
Apperley J.F. , Gardembas M. , Melo J.V. , Russell-Jones R. , Bain B.J. , Baxter E.J. , Chase A. , Chessells J.M. , Colombat M. , Dearden C.E. , Dimitrijevic S. , Mahon F.-X. , Marin D. , Nikolova Z. , Olavarria E. , Silberman S. , Schultheis B. , Cross N.C.P. , more...
N. Engl. J. Med.347:481-487(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH ETV6
33.

"Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib."
Wilkinson K. , Velloso E.R.P. , Lopes L.F. , Lee C. , Aster J.C. , Shipp M.A. , Aguiar R.C.T.
Blood102:4187-4190(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PDE4DIP
34.

"HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)."
Morerio C. , Acquila M. , Rosanda C. , Rapella A. , Dufour C. , Locatelli F. , Maserati E. , Pasquali F. , Panarello C.
Cancer Res.64:2649-2651(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH SPECC1
35.

"p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder."
Grand F.H. , Burgstaller S. , Kuhr T. , Baxter E.J. , Webersinke G. , Thaler J. , Chase A.J. , Cross N.C.
Cancer Res.64:7216-7219(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TP53BP1;ENZYME REGULATION
36.

"Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase."
Persson C. , Saevenhed C. , Bourdeau A. , Tremblay M.L. , Markova B. , Boehmer F.D. , Haj F.G. , Neel B.G. , Elson A. , Heldin C.H. , Roennstrand L. , Ostman A. , Hellberg C.
Mol. Cell. Biol.24:2190-2201(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-579; TYR-751; TYR-771 AND TYR-1021;DEPHOSPHORYLATION AT TYR-579 AND TYR-1021 BY PTPN2
37.

"Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II."
Choi M.H. , Lee I.K. , Kim G.W. , Kim B.U. , Han Y.H. , Yu D.Y. , Park H.S. , Kim K.Y. , Lee J.S. , Choi C. , Bae Y.S. , Lee B.I. , Rhee S.G. , Kang S.W.
Nature435:347-353(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-579; TYR-581; TYR-716; TYR-740; TYR-771; TYR-857; TYR-1009 AND TYR-1021
38.

"Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation."
Reddi A.L. , Ying G. , Duan L. , Chen G. , Dimri M. , Douillard P. , Druker B.J. , Naramura M. , Band V. , Band H.
J. Biol. Chem.282:29336-29347(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-1021;UBIQUITINATION
39.

"A novel signaling axis of matriptase/PDGF-D/ss-PDGFR in human prostate cancer."
Ustach C.V. , Huang W. , Conley-LaComb M.K. , Lin C.Y. , Che M. , Abrams J. , Kim H.R.
Cancer Res.70:9631-9640(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFD RECEPTOR
40.

"Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration."
Wardega P. , Heldin C.H. , Lennartsson J.
Cell. Signal.22:1363-1368(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CBL; STAM; PDCD6IP/ALIX; PLCG1 AND PTPN11;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-634 AND TYR-857
41.

"Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways."
Mendelson K. , Swendeman S. , Saftig P. , Blobel C.P.
J. Biol. Chem.285:25024-25032(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
42.

"Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration."
Kim H.J. , Cha B.Y. , Choi B. , Lim J.S. , Woo J.T. , Kim J.S.
Br. J. Nutr.107:24-35(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SMOOTH MUSCLE CELL PROLIFERATION AND MIGRATION
43.

"Direct interaction between Shc and the platelet-derived growth factor beta-receptor."
Yokote K. , Mori S. , Hansen K. , McGlade J. , Pawson T. , Heldin C.H. , Claesson-Welsh L.
J. Biol. Chem.269:15337-15343(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHC1 AND GRB2;FUNCTION IN PHOSPHORYLATION OF SHC1
44.

"Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cgamma 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo."
Caglayan E. , Vantler M. , Leppanen O. , Gerhardt F. , Mustafov L. , Ten Freyhaus H. , Kappert K. , Odenthal M. , Zimmermann W.H. , Tallquist M.D. , Rosenkranz S.
J. Am. Coll. Cardiol.57:2527-2538(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SMOOTH MUSCLE CELL MIGRATION AND NEOINTIMA FORMATION AFTER BLOOD VESSEL INJURY;MUTAGENESIS OF TYR-740; TYR-751 AND TYR-1021
45.

"Signal transduction via platelet-derived growth factor receptors."
Heldin C.H. , Ostman A. , Ronnstrand L.
Biochim. Biophys. Acta1378:F79-113(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING AND AUTOPHOSPHORYLATION
46.

"PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma."
Ostman A.
Cytokine Growth Factor Rev.15:275-286(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
47.

"PDGF receptors as targets in tumor treatment."
Ostman A. , Heldin C.H.
Adv. Cancer Res.97:247-274(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
48.

"Role of platelet-derived growth factors in physiology and medicine."
Andrae J. , Gallini R. , Betsholtz C.
Genes Dev.22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; LIGANDS; ROLE IN DEVELOPMENT AND DISEASE AND ACTIVATION OF SIGNALING PATHWAYS
49.

"NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex."
Pauptit R.A. , Dennis C.A. , Derbyshire D.J. , Breeze A.L. , Weston S.A. , Rowsell S. , Murshudov G.N.
Acta Crystallogr. D57:1397-1404(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 751-755 IN COMPLEX WITH PIK3R1;COMPARISON WITH NMR ANALYSIS
50.

"Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors."
Karthikeyan S. , Leung T. , Ladias J.A.A.
J. Biol. Chem.277:18973-18978(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1102-1106 IN COMPLEX WITH SLC9A3R1;INTERACTION WITH SLC9A3R1
51.

"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."
Shim A.H. , Liu H. , Focia P.J. , Chen X. , Lin P.C. , He X.
Proc. Natl. Acad. Sci. U.S.A.107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 33-314 IN COMPLEX WITH PDGFB;SUBUNIT;GLYCOSYLATION AT ASN-45; ASN-89; ASN-103; ASN-215; ASN-230; ASN-292 AND ASN-307;DISULFIDE BONDS
52.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-29; LYS-282; LYS-485; HIS-589; TYR-718 AND ILE-882
53.

"Mutations in PDGFRB cause autosomal-dominant infantile myofibromatosis."
Martignetti J.A. , Tian L. , Li D. , Ramirez M.C. , Camacho-Vanegas O. , Camacho S.C. , Guo Y. , Zand D.J. , Bernstein A.M. , Masur S.K. , Kim C.E. , Otieno F.G. , Hou C. , Abdel-Magid N. , Tweddale B. , Metry D. , Fournet J.C. , Papp E. , more...
Am. J. Hum. Genet.92:1001-1007(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMF1 THR-660
54.

"A recurrent PDGFRB mutation causes familial infantile myofibromatosis."
Cheung Y.H. , Gayden T. , Campeau P.M. , Leduc C.A. , Russo D. , Nguyen V.H. , Guo J. , Qi M. , Guan Y. , Albrecht S. , Moroz B. , Eldin K.W. , Lu J.T. , Schwartzentruber J. , Malkin D. , Berghuis A.M. , Emil S. , Gibbs R.A. , more...
Am. J. Hum. Genet.92:996-1000(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMF1 CYS-561
55.

"Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification."
Nicolas G. , Pottier C. , Maltete D. , Coutant S. , Rovelet-Lecrux A. , Legallic S. , Rousseau S. , Vaschalde Y. , Guyant-Marechal L. , Augustin J. , Martinaud O. , Defebvre L. , Krystkowiak P. , Pariente J. , Clanet M. , Labauge P. , Ayrignac X. , Lefaucheur R. , more...
Neurology80:181-187(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IBGC4 PRO-658 AND TRP-987

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