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Index > Protein center > PDGFRB(Gene name) > Human
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  • PDGFRB (Gene name),
  • Beta-type platelet-derived growth factor receptor (Protein name ),  PGFRB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PDGFRB(PDGFR;PDGFR1);
    Protein name:
    Beta-type platelet-derived growth factor receptor(PDGF-R-beta);
    Alternative:
    Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1(PDGFR-1);CD140 antigen-like family member B;
    CD:
    CD140b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with PDGFRA. Interacts with APS. The autophosphorylated form interacts directly with SHB and with PIK3C2B, maybe indirectly. Interacts with GRB7 and GRB10.
    Function:
    Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1106
    Sequence:
    50:
    MRLPGAMPAL | ALKGELLLLS | LLLLLEPQIS | QGLVVTPPGP | ELVLNVSSTF | 
    100:
    VLTCSGSAPV | VWERMSQEPP | QEMAKAQDGT | FSSVLTLTNL | TGLDTGEYFC | 
    150:
    THNDSRGLET | DERKRLYIFV | PDPTVGFLPN | DAEELFIFLT | EITEITIPCR | 
    200:
    VTDPQLVVTL | HEKKGDVALP | VPYDHQRGFS | GIFEDRSYIC | KTTIGDREVD | 
    250:
    SDAYYVYRLQ | VSSINVSVNA | VQTVVRQGEN | ITLMCIVIGN | EVVNFEWTYP | 
    300:
    RKESGRLVEP | VTDFLLDMPY | HIRSILHIPS | AELEDSGTYT | CNVTESVNDH | 
    350:
    QDEKAINITV | VESGYVRLLG | EVGTLQFAEL | HRSRTLQVVF | EAYPPPTVLW | 
    400:
    FKDNRTLGDS | SAGEIALSTR | NVSETRYVSE | LTLVRVKVAE | AGHYTMRAFH | 
    450:
    EDAEVQLSFQ | LQINVPVRVL | ELSESHPDSG | EQTVRCRGRG | MPQPNIIWSA | 
    500:
    CRDLKRCPRE | LPPTLLGNSS | EEESQLETNV | TYWEEEQEFE | VVSTLRLQHV | 
    550:
    DRPLSVRCTL | RNAVGQDTQE | VIVVPHSLPF | KVVVISAILA | LVVLTIISLI | 
    600:
    ILIMLWQKKP | RYEIRWKVIE | SVSSDGHEYI | YVDPMQLPYD | STWELPRDQL | 
    650:
    VLGRTLGSGA | FGQVVEATAH | GLSHSQATMK | VAVKMLKSTA | RSSEKQALMS | 
    700:
    ELKIMSHLGP | HLNVVNLLGA | CTKGGPIYII | TEYCRYGDLV | DYLHRNKHTF | 
    750:
    LQHHSDKRRP | PSAELYSNAL | PVGLPLPSHV | SLTGESDGGY | MDMSKDESVD | 
    800:
    YVPMLDMKGD | VKYADIESSN | YMAPYDNYVP | SAPERTCRAT | LINESPVLSY | 
    850:
    MDLVGFSYQV | ANGMEFLASK | NCVHRDLAAR | NVLICEGKLV | KICDFGLARD | 
    900:
    IMRDSNYISK | GSTFLPLKWM | APESIFNSLY | TTLSDVWSFG | ILLWEIFTLG | 
    950:
    GTPYPELPMN | EQFYNAIKRG | YRMAQPAHAS | DEIYEIMQKC | WEEKFEIRPP | 
    1000:
    FSQLVLLLER | LLGEGYKKKY | QQVDEEFLRS | DHPAILRSQA | RLPGFHGLRS | 
    1050:
    PLDTSSVLYT | AVQPNEGDND | YIIPLPDPKP | EVADEGPLEG | SPSLASSTLN | 
    1100:
    EVNTSSTISC | DSPLEPQDEP | EPEPQLELQV | EPEPELEQLP | DSGCPAPRAE | 
    1106:
    AEDSFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    MIM:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human PDGF-R-beta
    Cat.:
    E2061r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PDGF-R-beta
    Cat.:
    E2061m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PDGF-R-beta
    Cat.:
    E2061h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human PDGF-R-beta
    Cat.:
    E2061d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PDGF-R-beta
    Cat.:
    U2061r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PDGF-R-beta
    Cat.:
    U2061h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PDGF-R-beta
    Cat.:
    U2061m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PDGF-R-beta
    Cat.:
    U2061d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PDGF-R-beta
    Cat.:
    P2061Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF-R-beta
    Cat.:
    P2061Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PDGF-R-beta
    Polyclonal Antibody for Human PDGF-R-beta
    Cat.:
    P2061Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PDGF-R-beta
    Monoclonal Antibody for Human PDGF-R-beta
    Monoclonal Antibody for Human PDGF-R-beta
    Monoclonal Antibody for Human PDGF-R-beta
    Protein for Human PDGF-R-beta
    Protein for Human PDGF-R-beta
    Protein for Human PDGF-R-beta
    Protein for Human PDGF-R-beta

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class."
      Gronwald R.G.K. , Grant F.J. , Haldeman B.A. , Hart C.E. , O'Hara P.J. , Hagen F.S. , Ross R. , Bowen-Pope D.F. , Murray M.J.
      Proc. Natl. Acad. Sci. U.S.A.85:3435-3439(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS PDGFB RECEPTOR;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION;INTERACTION WITH PDGFB
    2. 2.
      "cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules."
      Claesson-Welsh L. , Eriksson A. , Moren A. , Severinsson L. , Ek B. , Oestman A. , Betsholtz C. , Heldin C.-H.
      Mol. Cell. Biol.8:3476-3486(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS PDGFB RECEPTOR;SUBCELLULAR LOCATION;GLYCOSYLATION;AUTOPHOSPHORYLATION;INTERACTION WITH PDGFA AND PDGFB
    3. 3.
      "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
      Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
      Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PHE-180
      tissue: Brain.
    5. 6.
      "Integration of proviral DNA into the PDGF beta-receptor gene in HTLV-I-infected T-cells results in a novel tyrosine kinase product with transforming activity."
      Chi K.D. , McPhee R.A. , Wagner A.S. , Dietz J.J. , Pantazis P. , Goustin A.S.
      Oncogene15:1051-1057(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 548-569
    6. 7.
      "Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm."
      Chmielecki J. , Peifer M. , Viale A. , Hutchinson K. , Giltnane J. , Socci N.D. , Hollis C.J. , Dean R.S. , Yenamandra A. , Jagasia M. , Kim A.S. , Dave U.P. , Thomas R.K. , Pao W.
      Genes Chromosomes Cancer51:54-65(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 559-1106 (ISOFORM 1);CHROMOSOMAL TRANSLOCATION WITH CEP85L
    7. 8.
      "Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes."
      Roberts W.M. , Look A.T. , Roussel M.F. , Sherr C.J.
      Cell55:655-661(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1046-1106
    8. 9.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-47
    9. 10.
      "Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins."
      Kazlauskas A. , Cooper J.A.
      Cell58:1121-1133(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-751 AND TYR-857
    10. 11.
      "Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways."
      Matsui T. , Pierce J.H. , Fleming T.P. , Greenberger J.S. , LaRochelle W.J. , Ruggiero M. , Aaronson S.A.
      Proc. Natl. Acad. Sci. U.S.A.86:8314-8318(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CELL PROLIFERATION AND CHEMOTAXIS;SUBCELLULAR LOCATION
    11. 12.
      "Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit."
      Kazlauskas A. , Durden D.L. , Cooper J.A.
      Cell Regul.2:413-425(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION; ACTIVATION OF PLCG1 AND IN PHOSPHORYLATION OF PLCG1 AND RASA1/GAP;MUTAGENESIS OF TYR-751 AND TYR-857
    12. 13.
      "Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation."
      Kelly J.D. , Haldeman B.A. , Grant F.J. , Murray M.J. , Seifert R.A. , Bowen-Pope D.F. , Cooper J.A. , Kazlauskas A.
      J. Biol. Chem.266:8987-8992(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA; PDGFA AND PDGFB;FUNCTION AS RECEPTOR FOR PDGFA AND PDGFB;PHOSPHORYLATION AT TYR-857 AND TYR-751
    13. 14.
      "Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor."
      Sorkin A. , Westermark B. , Heldin C.H. , Claesson-Welsh L.
      J. Cell Biol.112:469-478(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR PDGFA AND PDGFB;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-634
    14. 15.
      "Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo."
      Kashishian A. , Kazlauskas A. , Cooper J.A.
      EMBO J.11:1373-1382(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY;INTERACTION WITH PIK3R1 AND RASA1;PHOSPHORYLATION AT TYR-740; TYR-751; TYR-771 AND TYR-857;MUTAGENESIS OF LYS-634; TYR-716; TYR-740; TYR-751; TYR-763; TYR-771; TYR-775; TYR-778 AND TYR-857
    15. 16.
      "Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma."
      Ronnstrand L. , Mori S. , Arridsson A.K. , Eriksson A. , Wernstedt C. , Hellman U. , Claesson-Welsh L. , Heldin C.H.
      EMBO J.11:3911-3919(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CELL PROLIFERATION AND PHOSPHORYLATION OF PLCG1;INTERACTION WITH PLCG1;PHOSPHORYLATION AT TYR-1009 AND TYR-1021;MUTAGENESIS OF TYR-1009 AND TYR-1021
    16. 17.
      "Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor."
      Mori S. , Heldin C.H. , Claesson-Welsh L.
      J. Biol. Chem.267:6429-6434(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEGRADATION
    17. 18.
      "GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit."
      Kazlauskas A. , Kashishian A. , Cooper J.A. , Valius M.
      Mol. Cell. Biol.12:2534-2544(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1 AND RASA1;MUTAGENESIS OF TYR-740; TYR-751 AND TYR-771
    18. 19.
      "Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases."
      Mori S. , Ronnstrand L. , Yokote K. , Engstrom A. , Courtneidge S.A. , Claesson-Welsh L. , Heldin C.H.
      EMBO J.12:2257-2264(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFB RECEPTOR IN CELL PROLIFERATION;PHOSPHORYLATION AT TYR-579 AND TYR-581; INTERACTION WITH SRC;CATALYTIC ACTIVITY;MUTAGENESIS OF TYR-579 AND TYR-581
    19. 20.
      "Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor."
      Fretto L.J. , Snape A.J. , Tomlinson J.E. , Seroogy J.J. , Wolf D.L. , LaRochelle W.J. , Giese N.A.
      J. Biol. Chem.268:3625-3631(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DGFA AND PDGFB
    20. 21.
      "Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor."
      Lechleider R.J. , Sugimoto S. , Bennett A.M. , Kashishian A.S. , Cooper J.A. , Shoelson S.E. , Walsh C.T. , Neel B.G.
      J. Biol. Chem.268:21478-21481(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION AND ACTIVATION OF PTPN11;INTERACTION WITH PTPN11; PIK3R1; PLCG1 AND RASA1;MUTAGENESIS OF TYR-1009
    21. 22.
      "Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor."
      Nishimura R. , Li W. , Kashishian A. , Mondino A. , Zhou M. , Cooper J. , Schlessinger J.
      Mol. Cell. Biol.13:6889-6896(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCK1 AND PIK3R1;FUNCTION IN PHOSPHORYLATION OF NCK1;MUTAGENESIS OF TYR-751
    22. 23.
      "Shb is a ubiquitously expressed Src homology 2 protein."
      Welsh M. , Mares J. , Karlsson T. , Lavergne C. , Breant B. , Claesson-Welsh L.
      Oncogene9:19-27(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
    23. 24.
      "Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors."
      Yokote K. , Margolis B. , Heldin C.H. , Claesson-Welsh L.
      J. Biol. Chem.271:30942-30949(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB7
    24. 25.
      "Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution."
      Abe A. , Emi N. , Tanimoto M. , Terasaki H. , Marunouchi T. , Saito H.
      Blood90:4271-4277(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TRIP11
    25. 26.
      "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis."
      Wang J. , Dai H. , Yousaf N. , Moussaif M. , Deng Y. , Boufelliga A. , Swamy O.R. , Leone M.E. , Riedel H.
      Mol. Cell. Biol.19:6217-6228(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB10;MUTAGENESIS OF TYR-579; TYR-581; TYR-716; TYR-740; TYR-751; TYR-771; TYR-857; TYR-1009 AND TYR-1021
    26. 27.
      "APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis."
      Yokouchi M. , Wakioka T. , Sakamoto H. , Yasukawa H. , Ohtsuka S. , Sasaki A. , Ohtsubo M. , Valius M. , Inoue A. , Komiya S. , Yoshimura A.
      Oncogene18:759-767(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B2/APS
    27. 28.
      "Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1."
      Kovalenko M. , Denner K. , Sandstrom J. , Persson C. , Gross S. , Jandt E. , Vilella R. , Bohmer F. , Ostman A.
      J. Biol. Chem.275:16219-16226(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-562; TYR-751; TYR-763; TYR-771; TYR-775; TYR-778; TYR-857; TYR-1009 AND TYR-1021;DEPHOSPHORYLATION AT TYR-751; TYR-857; TYR-1009 AND TYR-1021 BY PTPRJ
    28. 29.
      "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors."
      Arcaro A. , Zvelebil M.J. , Wallasch C. , Ullrich A. , Waterfield M.D. , Domin J.
      Mol. Cell. Biol.20:3817-3830(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3C2B
    29. 30.
      "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
      Gilbertson D.G. , Duff M.E. , West J.W. , Kelly J.D. , Sheppard P.O. , Hofstrand P.D. , Gao Z. , Shoemaker K. , Bukowski T.R. , Moore M. , Feldhaus A.L. , Humes J.M. , Palmer T.E. , Hart C.E.
      J. Biol. Chem.276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR PDGFC;INTERACTION WITH PDGFC
    30. 31.
      "PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor."
      Bergsten E. , Uutela M. , Li X. , Pietras K. , Oestman A. , Heldin C.-H. , Alitalo K. , Eriksson U.
      Nat. Cell Biol.3:512-516(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A RECEPTOR FOR PDGFD
    31. 32.
      "Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta."
      Apperley J.F. , Gardembas M. , Melo J.V. , Russell-Jones R. , Bain B.J. , Baxter E.J. , Chase A. , Chessells J.M. , Colombat M. , Dearden C.E. , Dimitrijevic S. , Mahon F.-X. , Marin D. , Nikolova Z. , Olavarria E. , Silberman S. , Schultheis B. , Cross N.C.P. , more...
      N. Engl. J. Med.347:481-487(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH ETV6
    32. 33.
      "Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib."
      Wilkinson K. , Velloso E.R.P. , Lopes L.F. , Lee C. , Aster J.C. , Shipp M.A. , Aguiar R.C.T.
      Blood102:4187-4190(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PDE4DIP
    33. 34.
      "HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)."
      Morerio C. , Acquila M. , Rosanda C. , Rapella A. , Dufour C. , Locatelli F. , Maserati E. , Pasquali F. , Panarello C.
      Cancer Res.64:2649-2651(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH SPECC1
    34. 35.
      "p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder."
      Grand F.H. , Burgstaller S. , Kuhr T. , Baxter E.J. , Webersinke G. , Thaler J. , Chase A.J. , Cross N.C.
      Cancer Res.64:7216-7219(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH TP53BP1;ENZYME REGULATION
    35. 36.
      "Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase."
      Persson C. , Saevenhed C. , Bourdeau A. , Tremblay M.L. , Markova B. , Boehmer F.D. , Haj F.G. , Neel B.G. , Elson A. , Heldin C.H. , Roennstrand L. , Ostman A. , Hellberg C.
      Mol. Cell. Biol.24:2190-2201(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-579; TYR-751; TYR-771 AND TYR-1021;DEPHOSPHORYLATION AT TYR-579 AND TYR-1021 BY PTPN2
    36. 37.
      "Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II."
      Choi M.H. , Lee I.K. , Kim G.W. , Kim B.U. , Han Y.H. , Yu D.Y. , Park H.S. , Kim K.Y. , Lee J.S. , Choi C. , Bae Y.S. , Lee B.I. , Rhee S.G. , Kang S.W.
      Nature435:347-353(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-579; TYR-581; TYR-716; TYR-740; TYR-771; TYR-857; TYR-1009 AND TYR-1021
    37. 38.
      "Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation."
      Reddi A.L. , Ying G. , Duan L. , Chen G. , Dimri M. , Douillard P. , Druker B.J. , Naramura M. , Band V. , Band H.
      J. Biol. Chem.282:29336-29347(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL;SUBCELLULAR LOCATION;MUTAGENESIS OF TYR-1021;UBIQUITINATION
    38. 39.
      "A novel signaling axis of matriptase/PDGF-D/ss-PDGFR in human prostate cancer."
      Ustach C.V. , Huang W. , Conley-LaComb M.K. , Lin C.Y. , Che M. , Abrams J. , Kim H.R.
      Cancer Res.70:9631-9640(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS PDGFD RECEPTOR
    39. 40.
      "Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration."
      Wardega P. , Heldin C.H. , Lennartsson J.
      Cell. Signal.22:1363-1368(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CBL; STAM; PDCD6IP/ALIX; PLCG1 AND PTPN11;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-634 AND TYR-857
    40. 41.
      "Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways."
      Mendelson K. , Swendeman S. , Saftig P. , Blobel C.P.
      J. Biol. Chem.285:25024-25032(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    41. 42.
      "Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration."
      Kim H.J. , Cha B.Y. , Choi B. , Lim J.S. , Woo J.T. , Kim J.S.
      Br. J. Nutr.107:24-35(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SMOOTH MUSCLE CELL PROLIFERATION AND MIGRATION
    42. 43.
      "Direct interaction between Shc and the platelet-derived growth factor beta-receptor."
      Yokote K. , Mori S. , Hansen K. , McGlade J. , Pawson T. , Heldin C.H. , Claesson-Welsh L.
      J. Biol. Chem.269:15337-15343(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHC1 AND GRB2;FUNCTION IN PHOSPHORYLATION OF SHC1
    43. 44.
      "Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cgamma 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo."
      Caglayan E. , Vantler M. , Leppanen O. , Gerhardt F. , Mustafov L. , Ten Freyhaus H. , Kappert K. , Odenthal M. , Zimmermann W.H. , Tallquist M.D. , Rosenkranz S.
      J. Am. Coll. Cardiol.57:2527-2538(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SMOOTH MUSCLE CELL MIGRATION AND NEOINTIMA FORMATION AFTER BLOOD VESSEL INJURY;MUTAGENESIS OF TYR-740; TYR-751 AND TYR-1021
    44. 45.
      "Signal transduction via platelet-derived growth factor receptors."
      Heldin C.H. , Ostman A. , Ronnstrand L.
      Biochim. Biophys. Acta1378:F79-113(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING AND AUTOPHOSPHORYLATION
    45. 46.
      "PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma."
      Ostman A.
      Cytokine Growth Factor Rev.15:275-286(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    46. 47.
      "PDGF receptors as targets in tumor treatment."
      Ostman A. , Heldin C.H.
      Adv. Cancer Res.97:247-274(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    47. 48.
      "Role of platelet-derived growth factors in physiology and medicine."
      Andrae J. , Gallini R. , Betsholtz C.
      Genes Dev.22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; LIGANDS; ROLE IN DEVELOPMENT AND DISEASE AND ACTIVATION OF SIGNALING PATHWAYS
    48. 49.
      "NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex."
      Pauptit R.A. , Dennis C.A. , Derbyshire D.J. , Breeze A.L. , Weston S.A. , Rowsell S. , Murshudov G.N.
      Acta Crystallogr. D57:1397-1404(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 751-755 IN COMPLEX WITH PIK3R1;COMPARISON WITH NMR ANALYSIS
    49. 50.
      "Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors."
      Karthikeyan S. , Leung T. , Ladias J.A.A.
      J. Biol. Chem.277:18973-18978(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1102-1106 IN COMPLEX WITH SLC9A3R1;INTERACTION WITH SLC9A3R1
    50. 51.
      "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."
      Shim A.H. , Liu H. , Focia P.J. , Chen X. , Lin P.C. , He X.
      Proc. Natl. Acad. Sci. U.S.A.107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 33-314 IN COMPLEX WITH PDGFB;SUBUNIT;GLYCOSYLATION AT ASN-45; ASN-89; ASN-103; ASN-215; ASN-230; ASN-292 AND ASN-307;DISULFIDE BONDS
    51. 53.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMF1 THR-660
    52. 54.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IMF1 CYS-561
    53. 55.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IBGC4 PRO-658 AND TRP-987
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