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Index > Protein center > DCN(Gene name) > Human
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  • DCN (Gene name),
  • Decorin (Protein name ),  PGS2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
  • |
  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    DCN(SLRR1B);
    Protein name:
    Decorin;
    Alternative:
    PG-S2;Bone proteoglycan II;PG40;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.
    Function:
    May affect the rate of fibrils formation.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    359
    Sequence:
    50:
    MKATIILLLL | AQVSWAGPFQ | QRGLFDFMLE | DEASGIGPEV | PDDRDFEPSL | 
    100:
    GPVCPFRCQC | HLRVVQCSDL | GLDKVPKDLP | PDTTLLDLQN | NKITEIKDGD | 
    150:
    FKNLKNLHAL | ILVNNKISKV | SPGAFTPLVK | LERLYLSKNQ | LKELPEKMPK | 
    200:
    TLQELRAHEN | EITKVRKVTF | NGLNQMIVIE | LGTNPLKSSG | IENGAFQGMK | 
    250:
    KLSYIRIADT | NITSIPQGLP | PSLTELHLDG | NKISRVDAAS | LKGLNNLAKL | 
    300:
    GLSFNSISAV | DNGSLANTPH | LRELHLDNNK | LTRVPGGLAE | HKYIQVVYLH | 
    350:
    NNNISVVGSS | DFCPPGHNTK | KASYSGVSLF | SNPVQYWEIQ | PSTFRCVYVR | 
    359:
    SAIQLGNYK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    MIM:
    UniGene:
    String:
    UniGene:
    Pfam:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Decorin
    Cat.:
    E6238h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Decorin
    Cat.:
    E6238m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Decorin
    MSDS:
    Please sign in first.
    ELISA Kit for Human Decorin
    Cat.:
    E6238b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Decorin
    Cat.:
    E6238p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Decorin
    Cat.:
    E6238r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Decorin
    MSDS:
    Please sign in first.
    ELISA Kit for Human Decorin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Decorin
    Cat.:
    U6238r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Decorin
    Cat.:
    U6238h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Decorin
    Cat.:
    U6238b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Decorin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Decorin
    Cat.:
    U6238m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Decorin
    Cat.:
    U6238p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Decorin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Decorin
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Decorin
    Cat.:
    P6238Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Decorin
    Polyclonal Antibody for Human Decorin
    Polyclonal Antibody for Human Decorin
    Polyclonal Antibody for Human Decorin
    Polyclonal Antibody for Human Decorin
    Polyclonal Antibody for Human Decorin
    Polyclonal Antibody for Human Decorin
    Cat.:
    P6238Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Monoclonal Antibody for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin
    Protein for Human Decorin

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤8.1%

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    Recovery

    Recovery was determined by spiking various levels of PGS2 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    103

    94-105

    Plasma

    101

    93-106

     

     

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of PGS2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    96-110%

    98-107%

    95-109%

    99-108%

    Saliva(n=3)

    94-108%

    93-109%

    97-106%

    95-107%

    heparin plasma(n=5)

    93-111%

     

    95-105%

    94-110%

    98-106%

     

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    References
    1. 1.
      "Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA."
      Krusius T. , Ruoslahti E.
      Proc. Natl. Acad. Sci. U.S.A.83:7683-7687(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Human decorin gene: intron-exon junctions and chromosomal localization."
      Vetter U. , Vogel W. , Just W. , Young M.F. , Fisher L.W.
      Genomics15:161-168(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Lung.
    3. 3.
      "The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23."
      Danielson K.G. , Fazzio A. , Cohen I.R. , Cannizzaro L. , Iozzo R.V.
      Genomics15:146-160(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-70
    4. 4.
      "Alternative splicing of human decorin."
      Cs-Szabo G. , Glant T.T.
      Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B; C; D AND E)
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A)
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-268
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    8. 8.
      "Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II."
      Roughley P.J. , White R.J.
      Biochem. J.262:823-827(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-50
    9. 9.
      "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."
      Fisher L.W. , Hawkins G.R. , Tuross N. , Termine J.D.
      J. Biol. Chem.262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-49
    10. 10.
      "Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene."
      Bredrup C. , Knappskog P.M. , Majewski J. , Rodahl E. , Boman H.
      Invest. Ophthalmol. Vis. Sci.46:420-426(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CONGENITAL STROMAL CORNEAL DYSTROPHY
    11. 11.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-211 AND ASN-262
      tissue: Liver.
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