PIAS3 ELISA Kit for Human(Homo sapiens) | EIAab.comPIAS3 ELISA Kit for Human(Homo sapiens)

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PIAS3 (Gene name),

E3 SUMO-protein ligase PIAS3 (Protein name ), PIAS3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PIAS3;

Protein name:

E3 SUMO-protein ligase PIAS3;

Alternative:

Protein inhibitor of activated STAT protein 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds SUMO1 and UBE2I. Interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation (By similarity). Interacts with PLAG1. Interacts with ZFHX3.

Function:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

Subcellular Location:

Nucleus speckle

Protein Attributes:

Sequence length:

628

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

628:

GALREGHGGP | LPSGPSLTGC | RSDIISLD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:10401

String:

Q9Y6X2

MIM:

605987

Pfam:

PF14324

Pfam:

PF02891

SMR:

Q9Y6X2

UniGene:

Hs.435761

STRING:

9606.ENSP00000376765

Uniprot:

Q9Y6X2

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ELISA Kit for Human E3 SUMO-protein ligase PIAS3

Cat.:

E1591m

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96T

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ELISA Kit for Human E3 SUMO-protein ligase PIAS3

Cat.:

E1591h

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96T

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ELISA Kit for Human E3 SUMO-protein ligase PIAS3

Cat.:

E1591r

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96T

CLIA Kit for Human E3 SUMO-protein ligase PIAS3

Cat.:

U1591r

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96T

CLIA Kit for Human E3 SUMO-protein ligase PIAS3

Cat.:

U1591m

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MSDS:

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Packing:

96T

CLIA Kit for Human E3 SUMO-protein ligase PIAS3

Cat.:

U1591h

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Packing:

96T

Polyclonal Antibody for Human E3 SUMO-protein ligase PIAS3

Cat.:

P1591Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human E3 SUMO-protein ligase PIAS3

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P1591Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human E3 SUMO-protein ligase PIAS3

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P1591Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human E3 SUMO-protein ligase PIAS3

Protein for Human E3 SUMO-protein ligase PIAS3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3)."
Ueki N. , Seki N. , Yano K. , Saito T. , Masuho Y. , Muramatsu M.-A.
J. Hum. Genet.44:193-196(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-628
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Blood.
tissue: Muscle.
3.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-628
tissue: Mammary cancer.
4.

"Specific inhibition of Stat3 signal transduction by PIAS3."
Chung C.D. , Liao J. , Liu B. , Rao X. , Jay P. , Berta P. , Shuai K.
Science278:1803-1805(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STAT3;TISSUE SPECIFICITY
5.

"Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells."
Junicho A. , Matsuda T. , Yamamoto T. , Kishi H. , Korkmaz K. , Saatcioglu F. , Fuse H. , Muraguchi A.
Biochem. Biophys. Res. Commun.278:9-13(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AR;INDUCTION
6.

"The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3."
Roedel B. , Tavassoli K. , Karsunky H. , Schmidt T. , Bachmann M. , Schaper F. , Heinrich P. , Shuai K. , Elsaesser H.-P. , Moeroey T.
EMBO J.19:5845-5855(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GFI1
7.

"ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3."
Nojiri S. , Joh T. , Miura Y. , Sakata N. , Nomura T. , Nakao H. , Sobue S. , Ohara H. , Asai K. , Ito M.
Biochem. Biophys. Res. Commun.314:97-103(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFHX3
8.

"Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation."
Van Dyck F. , Delvaux E.L.D. , Van de Ven W.J.M. , Chavez M.V.
J. Biol. Chem.279:36121-36131(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLAG1
9.

"SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function."
Cong L. , Pakala S.B. , Ohshiro K. , Li D.Q. , Kumar R.
J. Biol. Chem.286:43793-43808(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MTA1

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