Protein name:
Polycystin-2 ;
Alternative:
Polycystic kidney disease 2 protein ;Autosomal dominant polycystic kidney disease type II protein ;R48321 ;Polycystwin ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms homooligomers. Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1. Interacts with NEK8.
Function:
Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
Subcellular Location:
Membrane
Multi-pass membrane protein
Endoplasmic reticulum
Protein Attributes:
50:
MVNSSRVQPQ | QPGDAKRPPA | PRAPDPGRLM | AGCAAVGASL | AAPGGLCEQR |
100:
GLEIEMQRIR | QAAARDPPAG | AAASPSPPLS | SCSRQAWSRD | NPGFEAEEEE |
150:
EEVEGEEGGM | VVEMDVEWRP | GSRRSAASSA | VSSVGARSRG | LGGYHGAGHP |
200:
SGRRRRREDQ | GPPCPSPVGG | GDPLHRHLPL | EGQPPRVAWA | ERLVRGLRGL |
250:
WGTRLMEESS | TNREKYLKSV | LRELVTYLLF | LIVLCILTYG | MMSSNVYYYT |
300:
RMMSQLFLDT | PVSKTEKTNF | KTLSSMEDFW | KFTEGSLLDG | LYWKMQPSNQ |
350:
TEADNRSFIF | YENLLLGVPR | IRQLRVRNGS | CSIPQDLRDE | IKECYDVYSV |
400:
SSEDRAPFGP | RNGTAWIYTS | EKDLNGSSHW | GIIATYSGAG | YYLDLSRTRE |
450:
ETAAQVASLK | KNVWLDRGTR | ATFIDFSVYN | ANINLFCVVR | LLVEFPATGG |
500:
VIPSWQFQPL | KLIRYVTTFD | FFLAACEIIF | CFFIFYYVVE | EILEIRIHKL |
550:
HYFRSFWNCL | DVVIVVLSVV | AIGINIYRTS | NVEVLLQFLE | DQNTFPNFEH |
600:
LAYWQIQFNN | IAAVTVFFVW | IKLFKFINFN | RTMSQLSTTM | SRCAKDLFGF |
650:
AIMFFIIFLA | YAQLAYLVFG | TQVDDFSTFQ | ECIFTQFRII | LGDINFAEIE |
700:
EANRVLGPIY | FTTFVFFMFF | ILLNMFLAII | NDTYSEVKSD | LAQQKAEMEL |
750:
SDLIRKGYHK | ALVKLKLKKN | TVDDISESLR | QGGGKLNFDE | LRQDLKGKGH |
800:
TDAEIEAIFT | KYDQDGDQEL | TEHEHQQMRD | DLEKEREDLD | LDHSSLPRPM |
850:
SSRSFPRSLD | DSEEDDDEDS | GHSSRRRGSI | SSGVSYEEFQ | VLVRRVDRME |
900:
HSIGSIVSKI | DAVIVKLEIM | ERAKLKRREV | LGRLLDGVAE | DERLGRDSEI |
950:
HREQMERLVR | EELERWESDD | AASQISHGLG | TPVGLNGQPR | PRSSRPSSSQ |
968:
STEGMEGAGG | NGSSNVHV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Human Polycystin-2
ELISA Kit for Human Polycystin-2
ELISA Kit for Human Polycystin-2
CLIA Kit for Human Polycystin-2
CLIA Kit for Human Polycystin-2
CLIA Kit for Human Polycystin-2
Polyclonal Antibody for Human Polycystin-2
Polyclonal Antibody for Human Polycystin-2
Polyclonal Antibody for Human Polycystin-2
Monoclonal Antibody for Human Polycystin-2
Monoclonal Antibody for Human Polycystin-2
Monoclonal Antibody for Human Polycystin-2
Protein for Human Polycystin-2
Protein for Human Polycystin-2
Protein for Human Polycystin-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein."
Mochizuki T.
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Wu G.
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Science272:1339-1342(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-28
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 361-968 (ISOFORM 1)
tissue :
Mammary gland .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CD2AP
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HAX1;SUBCELLULAR LOCATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
8.
"A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1."
Hackmann K.
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Markoff A.
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Qian F.
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Germino G.G.
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Hum. Mol. Genet.14:3249-3262(2005)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS 2; 3; 4 AND 5)
9.
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W.
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Lu Z.
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Fu Y.
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Wang H.P.
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Chi H.
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Yuan Z.F.
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Zheng Z.B.
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Song L.N.
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Han H.H.
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Wang J.L.
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Qian X.H.
Mol. Cell. Proteomics8:913-923(2009)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-328
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-812;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : 3D-STRUCTURE MODELING;PROTEIN SEQUENCE OF 711-715; 720-724; 804-808 AND 823-827;IDENTIFICATION BY MASS SPECTROMETRY;DOMAIN;CALCIUM-BINDING;CIRCULAR DICHROISM;SUBUNIT;MUTAGENESIS OF THR-771; GLU-774; LEU-842; VAL-846; MET-849; ILE-853; ILE-856 AND VAL-863
12.
"A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2)."
Veldhuisen B.
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Saris J.J.
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de Haij S.
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Hayashi T.
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Reynolds D.M.
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Mochizuki T.
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Elles R.
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Am. J. Hum. Genet.61:547-555(1997)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKD2 GLY-414
13.
"Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease."
Reynolds D.M.
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Hayashi T.
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Cai Y.
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Veldhuisen B.
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Watnick T.J.
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Lens X.M.
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J. Am. Soc. Nephrol.10:2342-2351(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKD2 VAL-511
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKD2 PRO-356;VARIANT PRO-28
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKD2 ILE-479 DEL; 504-ARG--VAL-512 DEL AND TYR-684 DEL
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKD2 TRP-322;VARIANTS LEU-24; PRO-28 AND LEU-800
17.
"Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease."
Magistroni R.
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He N.
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Wang K.
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Andrew R.
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Johnson A.
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Gabow P.
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Dicks E.
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Parfrey P.
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Torra R.
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San-Millan J.L.
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Coto E.
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Van Dijk M.
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Breuning M.
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Peters D.
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Bogdanova N.
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Ligabue G.
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Albertazzi A.
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Hateboer N.
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Demetriou K.
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more...
J. Am. Soc. Nephrol.14:1164-1174(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKD2 PRO-356; GLY-414; ARG-632 AND GLN-807
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PKD2 GLN-306 AND GLY-420;VARIANT PRO-28
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKD2 GLN-322
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS PRO-28; THR-190 AND CYS-482
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PKD2 PRO-384