JUP ELISA Kit for Human(Homo sapiens) | EIAab.comJUP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > JUP(Gene name) > Human

JUP (Gene name),

Junction plakoglobin (Protein name ), PLAK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

JUP(CTNNG;DP3);

Protein name:

Junction plakoglobin;

Alternative:

Desmoplakin III;Catenin gamma;Desmoplakin-3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1 (By similarity). Interacts with PTPRJ. Interacts with DSC2.

Function:

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

Subcellular Location:

Cell junction adherens junction Cell junction desmosome Cytoplasm cytoskeleton Membrane Peripheral membrane protein Cytoplasmic in a soluble and membrane-associated form.

Protein Attributes:

Sequence length:

745

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

745:

YRPMYSSDVP | LDPLEMHMDM | DGDYPIDTYS | DGLRPPYPTA | DHMLA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00514

KEGG:

hsa:3728

MIM:

173325

STRING:

9606.ENSP00000311113

String:

P14923

UniGene:

Hs.514174

SMR:

P14923

Uniprot:

P14923

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ELISA Kit for Human Junction plakoglobin

Cat.:

E15107h

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Manual:

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Packing:

96T

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ELISA Kit for Human Junction plakoglobin

MSDS:

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ELISA Kit for Human Junction plakoglobin

MSDS:

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ELISA Kit for Human Junction plakoglobin

MSDS:

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ELISA Kit for Human Junction plakoglobin

MSDS:

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CLIA Kit for Human Junction plakoglobin

MSDS:

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CLIA Kit for Human Junction plakoglobin

Cat.:

U15107h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Junction plakoglobin

MSDS:

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CLIA Kit for Human Junction plakoglobin

MSDS:

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CLIA Kit for Human Junction plakoglobin

MSDS:

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Polyclonal Antibody for Human Junction plakoglobin

Monoclonal Antibody for Human Junction plakoglobin

Protein for Human Junction plakoglobin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein."
Franke W.W. , Goldschmidt M.D. , Zimbelmann R. , Mueller H.M. , Schiller D.L. , Cowin P.
Proc. Natl. Acad. Sci. U.S.A.86:4027-4031(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Zimbelmann R.
Submitted (1995-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Genomic organization and amplification of the human plakoglobin gene (JUP)."
Whittock N.V. , Eady R.A.J. , McGrath J.A.
Exp. Dermatol.9:323-326(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Homo sapiens gamma-catenin mRNA from human KB epidermoid adenocarcinoma cells."
Liang X.-J. , Gottesman M.M.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-697
tissue: Epidermal carcinoma.
5.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-697
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-697
tissue: Lung.
tissue: Placenta.
8.

Bienvenut W.V. , Vousden K.H. , Lukashchuk N. , Calvo F. , Kolch W.
Submitted (2008-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-12; 116-142; 150-172; 177-203; 217-233; 273-279; 304-320; 327-333; 368-394; 427-460; 466-533; 583-602; 638-661 AND 664-674;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Cervix carcinoma.
tissue: Lung carcinoma.
9.

"Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)."
McKoy G. , Protonotarios N. , Crosby A. , Tsatsopoulou A. , Anastasakis A. , Coonar A. , Norman M. , Baboonian C. , Jeffery S. , McKenna W.J.
Lancet355:2119-2124(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 634-745;VARIANT LEU-697;INVOLVEMENT IN NAXOS DISEASE
tissue: Leukocyte.
10.

"Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion."
Butz S. , Kemler R.
FEBS Lett.355:195-200(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX
11.

"Desmosomal cadherin binding domains of plakoglobin."
Witcher L.L. , Collins R. , Puttagunta S. , Mechanic S.E. , Munson M. , Gumbiner B. , Cowin P.
J. Biol. Chem.271:10904-10909(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;INTERACTION WITH CTNNA1; DSC1 AND DSG1
12.

"Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion."
Yamamoto M. , Bharti A. , Li Y. , Kufe D.
J. Biol. Chem.272:12492-12494(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MUC1
13.

"Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin."
Nieset J.E. , Redfield A.R. , Jin F. , Knudsen K.A. , Johnson K.R. , Wheelock M.J.
J. Cell Sci.110:1013-1022(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNA1
14.

"The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)."
Holsinger L.J. , Ward K. , Duffield B. , Zachwieja J. , Jallal B.
Oncogene21:7067-7076(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRJ
15.

"Plakoglobin is O-glycosylated close to the N-terminal destruction box."
Hatsell S. , Medina L. , Merola J. , Haltiwanger R. , Cowin P.
J. Biol. Chem.278:37745-37752(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-14;MUTAGENESIS OF THR-14; THR-19; THR-21; SER-24; SER-28 AND THR-32
16.

"Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription."
Miravet S. , Piedra J. , Castano J. , Raurell I. , Franci C. , Dunach M. , Garcia de Herreros A.
Mol. Cell. Biol.23:7391-7402(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY FER
17.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-665;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
Gehmlich K. , Syrris P. , Peskett E. , Evans A. , Ehler E. , Asimaki A. , Anastasakis A. , Tsatsopoulou A. , Vouliotis A.I. , Stefanadis C. , Saffitz J.E. , Protonotarios N. , McKenna W.J.
Cardiovasc. Res.90:77-87(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSC2
21.

"Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations."
Kirchner F. , Schuetz A. , Boldt L.H. , Martens K. , Dittmar G. , Haverkamp W. , Thierfelder L. , Heinemann U. , Gerull B.
Circ. Cardiovasc. Genet.5:400-411(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PKP2;SUBCELLULAR LOCATION
22.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."
Choi H.J. , Gross J.C. , Pokutta S. , Weis W.I.
J. Biol. Chem.284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 124-676 IN COMPLEX WITH PHOSPHORYLATED MOUSE E-CADHERIN;DOMAIN ARM REPEATS;INTERACTION WITH DSC1 AND DSG1
24.

"A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
Asimaki A. , Syrris P. , Wichter T. , Matthias P. , Saffitz J.E. , McKenna W.J.
Am. J. Hum. Genet.81:964-973(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARVD12 SER-39 INS;CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS
25.

"Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
den Haan A.D. , Tan B.Y. , Zikusoka M.N. , Llado L.I. , Jain R. , Daly A. , Tichnell C. , James C. , Amat-Alarcon N. , Abraham T. , Russell S.D. , Bluemke D.A. , Calkins H. , Dalal D. , Judge D.P.
Circ. Cardiovasc. Genet.2:428-435(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARVD12 ILE-19;VARIANTS HIS-142; ILE-648 AND LEU-697
26.

"Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
Barahona-Dussault C. , Benito B. , Campuzano O. , Iglesias A. , Leung T.L. , Robb L. , Talajic M. , Brugada R.
Clin. Genet.77:37-48(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-142 AND LEU-697

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