Protein name:
Junction plakoglobin ;
Alternative:
Desmoplakin-3 ;Desmoplakin III ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ.
Function:
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Subcellular Location:
Cell junction
adherens junction
Cell junction
desmosome
Cytoplasm
cytoskeleton
Membrane
Peripheral membrane protein
Cytoplasmic in a soluble and membrane-associated form.
Protein Attributes:
50:
MEVMNLIEQP | IKVTEWQQTY | TYDSGIHSGV | NTCVPSVSSK | GIMDEDDACG |
100:
RQYTLKKTTT | YTQGVPQNQG | DLEYQMSTTA | RAKRVREAMC | PGVSGEDSSL |
150:
LLATQVEGQT | TNLQRLAEPS | QLLKSAIVHL | INYQDDAELA | TRALPELTKL |
200:
LNDEDPVVVT | KAAMIVNQLS | KKEASRRALM | GSPQLVAAVV | RTMQNTSDLD |
250:
TARCTTSILH | NLSHHREGLL | AIFKSGGIPA | LVRMLSSPVE | SVLFYAITTL |
300:
HNLLLYQEGA | KMAVRLADGL | QKMVPLLNKN | NPKFLAITTD | CLQLLAYGNQ |
350:
ESKLIILANG | GPQGLVQIMR | NYSYEKLLWT | TSRVLKVLSV | CPSNKPAIVE |
400:
AGGMQALGKH | LTSNSPRLVQ | NCLWTLRNLS | DVATKQEGLE | SVLKILVNQL |
450:
SVDDVNVLTC | ATGTLSNLTC | NNSKNKTLVT | QNSGVEALIH | AILRAGDKDD |
500:
ITEPAVCALR | HLTSRHPEAE | MAQNSVRLNY | GIPAIVKLLN | QPNQWPLVKA |
550:
TIGLIRNLAL | CPANHAPLQE | AAVIPRLVQL | LVKAHQDAQR | HVAAGTQQPY |
600:
TDGVRMEEIV | EGCTGALHIL | ARDPMNRMEI | FRLNTIPLFV | QLLYSSVENI |
650:
QRVAAGVLCE | LAQDKEAADA | IDAEGASAPL | MELLHSRNEG | TATYAAAVLF |
700:
RISEDKNPDY | RKRVSVELTN | SLFKHDPAAW | EAAQSMIPIN | EPYADDMDAT |
745:
YRPMYSSDVP | LDPLDMHMDL | DGDYPMDTYS | DGLRPPYPTA | DHMLA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Pig
Mouse
Rat
ELISA Kit for Mouse Junction plakoglobin
ELISA Kit for Mouse Junction plakoglobin
ELISA Kit for Mouse Junction plakoglobin
ELISA Kit for Mouse Junction plakoglobin
ELISA Kit for Mouse Junction plakoglobin
CLIA Kit for Mouse Junction plakoglobin
CLIA Kit for Mouse Junction plakoglobin
CLIA Kit for Mouse Junction plakoglobin
CLIA Kit for Mouse Junction plakoglobin
CLIA Kit for Mouse Junction plakoglobin
Polyclonal Antibody for Mouse Junction plakoglobin
Polyclonal Antibody for Mouse Junction plakoglobin
Polyclonal Antibody for Mouse Junction plakoglobin
Polyclonal Antibody for Mouse Junction plakoglobin
Polyclonal Antibody for Mouse Junction plakoglobin
Monoclonal Antibody for Mouse Junction plakoglobin
Monoclonal Antibody for Mouse Junction plakoglobin
Monoclonal Antibody for Mouse Junction plakoglobin
Monoclonal Antibody for Mouse Junction plakoglobin
Monoclonal Antibody for Mouse Junction plakoglobin
Protein for Mouse Junction plakoglobin
Protein for Mouse Junction plakoglobin
Protein for Mouse Junction plakoglobin
Protein for Mouse Junction plakoglobin
Protein for Mouse Junction plakoglobin
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NOD .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Colon .
tissue :
Mammary tumor .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 125-745
4.
Butz S.
Submitted (1996-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 418 AND 420
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RECONSTITUTION OF THE E-CADHERIN/CATENIN ADHESION COMPLEX;LACK OF ACTIN-BINDING BY THE E-CADHERIN/CATENIN ADHESION COMPLEX
7.
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,
Butz S.
,
Vestweber D.
J. Exp. Med.205:2929-2945(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION