Junction plakoglobin (Protein name
), PLAK_PIG from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Jup;
Protein name:
Junction plakoglobin;
Alternative:
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ.
Function:
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Subcellular Location:
Cell junction
adherens junction
Cell junction
desmosome
Cytoplasm
cytoskeleton
Membrane
Peripheral membrane protein
Cytoplasmic in a soluble and membrane-associated form.
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Precision
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Recovery
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Linearity
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References
1.
"Transcriptional upregulation of p27Kip1 during contact-induced growth arrest in endothelial cells." Hirano M.
,
Hirano K.
,
Nishimura J.
,
Kanaide H.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]