PLK1 ELISA Kit for Human(Homo sapiens) | EIAab.comPLK1 ELISA Kit for Human(Homo sapiens)

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PLK1 (Gene name),

Serine/threonine-protein kinase PLK1 (Protein name ), PLK1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PLK1(PLK);

Protein name:

Serine/threonine-protein kinase PLK1;

Alternative:

Serine/threonine-protein kinase 13(STPK13);Polo-like kinase 1(PLK-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, MLF1IP and CDC25C. Interacts with isoform 3 of SGOL1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD.

Function:

Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.

Subcellular Location:

Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton centrosome During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization.

Protein Attributes:

Sequence length:

603

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

603:

KAS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P53350

MIM:

602098

String:

P53350

KEGG:

hsa:5347

Pfam:

PF00069

UniGene:

Hs.592049

STRING:

9606.ENSP00000300093

Uniprot:

P53350

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ELISA Kit for Human Serine/threonine-protein kinase PLK1

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E1662h

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ELISA Kit for Human Serine/threonine-protein kinase PLK1

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E1662m

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ELISA Kit for Human Serine/threonine-protein kinase PLK1

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E1662r

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ELISA Kit for Human Serine/threonine-protein kinase PLK1

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E1662b

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96T

CLIA Kit for Human Serine/threonine-protein kinase PLK1

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U1662b

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96T

CLIA Kit for Human Serine/threonine-protein kinase PLK1

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U1662r

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96T

CLIA Kit for Human Serine/threonine-protein kinase PLK1

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U1662m

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96T

CLIA Kit for Human Serine/threonine-protein kinase PLK1

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U1662h

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Polyclonal Antibody for Human Serine/threonine-protein kinase PLK1

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P1662Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Serine/threonine-protein kinase PLK1

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P1662Rb-h

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Polyclonal Antibody for Human Serine/threonine-protein kinase PLK1

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P1662Rb-r

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Polyclonal Antibody for Human Serine/threonine-protein kinase PLK1

Monoclonal Antibody for Human Serine/threonine-protein kinase PLK1

Protein for Human Serine/threonine-protein kinase PLK1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase."
Hamanaka R. , Maloid S. , Smith M.R. , O'Connell C.D. , Longo D.L. , Ferris D.K.
Cell Growth Differ.5:249-257(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
2.

"Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase."
Lake R.J. , Jelinek W.R.
Mol. Cell. Biol.13:7793-7801(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5."
Golsteyn R.M. , Schultz S.J. , Bartek J. , Ziemiecki A. , Ried T. , Nigg E.A.
J. Cell Sci.107:1509-1517(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors."
Holtrich U. , Wolf G. , Braeuninger A. , Karn T. , Boehme B. , Ruebsamen-Waigmann H. , Strebhardt K.
Proc. Natl. Acad. Sci. U.S.A.91:1736-1740(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lung.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
tissue: Lung.
6.

"Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter."
Brauninger A. , Strebhardt K. , Rubsamen-Waigmann H.
Oncogene11:1793-1800(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-136
7.

"Cell cycle regulation of the human polo-like kinase (PLK) promoter."
Uchiumi T. , Longo D.L. , Ferris D.K.
J. Biol. Chem.272:9166-9174(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-136
8.

"Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes."
Lane H.A. , Nigg E.A.
J. Cell Biol.135:1701-1713(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CENTROSOME MATURATION;SUBCELLULAR LOCATION
9.

"The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase."
Roshak A.K. , Capper E.A. , Imburgia C. , Fornwald J. , Scott G. , Marshall L.A.
Cell. Signal.12:405-411(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDC25C
10.

"Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase."
Jang Y.-J. , Ma S. , Terada Y. , Erikson R.L.
J. Biol. Chem.277:44115-44120(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-137 AND THR-210;MUTAGENESIS OF LYS-82; SER-137 AND THR-210
11.

"Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1."
Yuan J. , Eckerdt F. , Bereiter-Hahn J. , Kurunci-Csacsko E. , Kaufmann M. , Strebhardt K.
Oncogene21:8282-8292(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CCNB1;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-82 AND THR-210
12.

"Identification of phosphorylation sites in the polo-like kinases Plx1 and Plk1 by a novel strategy based on element and electrospray high resolution mass spectrometry."
Wind M. , Kelm O. , Nigg E.A. , Lehmann W.D.
Proteomics2:1516-1523(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-335
13.

"Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation."
Casenghi M. , Meraldi P. , Weinhart U. , Duncan P.I. , Korner R. , Nigg E.A.
Dev. Cell5:113-125(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF NINL
14.

"Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue."
Walter S.A. , Cutler R.E. Jr. , Martinez R. , Gishizky M. , Hill R.J.
J. Biol. Chem.278:18221-18228(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY STK10
15.

"Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate."
Nakajima H. , Toyoshima-Morimoto F. , Taniguchi E. , Nishida E.
J. Biol. Chem.278:25277-25280(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PKMYT1
16.

"Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis."
Neef R. , Preisinger C. , Sutcliffe J. , Kopajtich R. , Nigg E.A. , Mayer T.U. , Barr F.A.
J. Cell Biol.162:863-875(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF KIF20A;DOMAIN POLO BOX;SUBCELLULAR LOCATION;INTERACTION WITH KIF20A
17.

"Active cyclin B1-Cdk1 first appears on centrosomes in prophase."
Jackman M. , Lindon C. , Nigg E.A. , Pines J.
Nat. Cell Biol.5:143-148(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CCNB1;SUBCELLULAR LOCATION
18.

"Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells."
Lindon C. , Pines J.
J. Cell Biol.164:233-241(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEASOMAL DEGRADATION;DOMAIN D-BOX MOTIF;MUTAGENESIS OF ARG-337 AND LEU-340
19.

"Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1."
Hansen D.V. , Loktev A.V. , Ban K.H. , Jackson P.K.
Mol. Biol. Cell15:5623-5634(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FBXO5
20.

"M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP."
Watanabe N. , Arai H. , Nishihara Y. , Taniguchi M. , Watanabe N. , Hunter T. , Osada H.
Proc. Natl. Acad. Sci. U.S.A.101:4419-4424(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF WEE1
21.

"Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome."
Moshe Y. , Boulaire J. , Pagano M. , Hershko A.
Proc. Natl. Acad. Sci. U.S.A.101:7937-7942(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FBXO5
22.

"Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis."
Fabbro M. , Zhou B.-B. , Takahashi M. , Sarcevic B. , Lal P. , Graham M.E. , Gabrielli B.G. , Robinson P.J. , Nigg E.A. , Ono Y. , Khanna K.K.
Dev. Cell9:477-488(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CEP55
23.

"The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles."
Guarguaglini G. , Duncan P.I. , Stierhof Y.D. , Holmstroem T. , Duensing S. , Nigg E.A.
Mol. Biol. Cell16:1095-1107(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CEP170
24.

"The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1."
Eldridge A.G. , Loktev A.V. , Hansen D.V. , Verschuren E.W. , Reimann J.D.R. , Jackson P.K.
Cell124:367-380(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EVI5
25.

"Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1."
Qi W. , Tang Z. , Yu H.
Mol. Biol. Cell17:3705-3716(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH BUB1 AND BUB1B;MUTAGENESIS OF HIS-538 AND LYS-540
26.

"The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity."
Oshimori N. , Ohsugi M. , Yamamoto T.
Nat. Cell Biol.8:1095-1101(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF KIZ
27.

"Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA."
Niiya F. , Tatsumoto T. , Lee K.S. , Miki T.
Oncogene25:827-837(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ECT2;INTERACTION WITH ECT2
28.

"Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation."
Kang Y.H. , Park J.-E. , Yu L.-R. , Soung N.-K. , Yun S.-M. , Bang J.K. , Seong Y.-S. , Yu H. , Garfield S. , Veenstra T.D. , Lee K.S.
Mol. Cell24:409-422(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CENPU
29.

"Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma."
Kanaji S. , Saito H. , Tsujitani S. , Matsumoto S. , Tatebe S. , Kondo A. , Ozaki M. , Ito H. , Ikeguchi M.
Oncology70:126-133(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
30.

"A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma."
Salvatore G. , Nappi T.C. , Salerno P. , Jiang Y. , Garbi C. , Ugolini C. , Miccoli P. , Basolo F. , Castellone M.D. , Cirafici A.M. , Melillo R.M. , Fusco A. , Bittner M.L. , Santoro M.
Cancer Res.67:10148-10158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
31.

"PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint."
Baumann C. , Koerner R. , Hofmann K. , Nigg E.A.
Cell128:101-114(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERCC6L
32.

"Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1."
Pouwels J. , Kukkonen A.M. , Lan W. , Daum J.R. , Gorbsky G.J. , Stukenberg T. , Kallio M.J.
Cell Cycle6:1579-1585(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
33.

"TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity."
Zhang Y. , Tian Y. , Chen Q. , Chen D. , Zhai Z. , Shu H.-B.
Cell. Mol. Life Sci.64:632-640(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTDN1
34.

"Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1."
Matsumura S. , Toyoshima F. , Nishida E.
J. Biol. Chem.282:15217-15227(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF BUB1B
35.

"Expression of PLK1 and survivin in diffuse large B-cell lymphoma."
Liu L. , Zhang M. , Zou P.
Leuk. Lymphoma48:2179-2183(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
36.

"Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1."
Neef R. , Gruneberg U. , Kopajtich R. , Li X. , Nigg E.A. , Sillje H. , Barr F.A.
Nat. Cell Biol.9:436-444(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PRC1;DOMAIN POLO BOX
37.

"The tumor suppressor CYLD regulates entry into mitosis."
Stegmeier F. , Sowa M.E. , Nalepa G. , Gygi S.P. , Harper J.W. , Elledge S.J.
Proc. Natl. Acad. Sci. U.S.A.104:8869-8874(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CYLD;IDENTIFICATION BY MASS SPECTROMETRY
38.

"The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint."
Bassermann F. , Frescas D. , Guardavaccaro D. , Busino L. , Peschiaroli A. , Pagano M.
Cell134:256-267(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY THE APC/C COMPLEX;INTERACTION WITH FZR1;MUTAGENESIS OF ARG-337 AND LEU-340
39.

"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
Pohl C. , Jentsch S.
Cell132:832-845(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIRC6/BRUCE
40.

"p73-mediated transcriptional activity is negatively regulated by polo-like kinase 1."
Soond S.M. , Barry S.P. , Melino G. , Knight R.A. , Latchman D.S. , Stephanou A.
Cell Cycle7:1214-1223(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TP73
41.

"Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora."
Chan E.H. , Santamaria A. , Sillje H.H. , Nigg E.A.
Chromosoma117:457-469(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PHOSPHORYLATED BORA
42.

"sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1."
Wang X. , Yang Y. , Duan Q. , Jiang N. , Huang Y. , Darzynkiewicz Z. , Dai W.
Dev. Cell14:331-341(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SGOL1;INTERACTION WITH SGOL1
43.

"Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1."
Yamashiro S. , Yamakita Y. , Totsukawa G. , Goto H. , Kaibuchi K. , Ito M. , Hartshorne D.J. , Matsumura F.
Dev. Cell14:787-797(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PPP1R12A;PHOSPHORYLATION AT THR-210;DEPHOSPHORYLATION BY PPP1C;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-538 AND LYS-540
44.

"Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation."
Koida N. , Ozaki T. , Yamamoto H. , Ono S. , Koda T. , Ando K. , Okoshi R. , Kamijo T. , Omura K. , Nakagawara A.
J. Biol. Chem.283:8555-8563(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TP73;MUTAGENESIS OF LYS-82
45.

"FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle."
Zhu H. , Coppinger J.A. , Jang C.-Y. , Yates J.R. III , Fang G.
J. Cell Biol.183:835-848(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM29A
46.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6; SER-103; THR-210; THR-214; SER-375; SER-450 AND THR-498;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
47.

"Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression."
Fu Z. , Malureanu L. , Huang J. , Wang W. , Li H. , van Deursen J.M. , Tindall D.J. , Chen J.
Nat. Cell Biol.10:1076-1082(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF FOXM1;MUTAGENESIS OF LYS-82 AND THR-210
48.

"Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery."
Macurek L. , Lindqvist A. , Lim D. , Lampson M.A. , Klompmaker R. , Freire R. , Clouin C. , Taylor S.S. , Yaffe M.B. , Medema R.H.
Nature455:119-123(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;PHOSPHORYLATION AT THR-210 BY AURKA;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-82; SER-137; ASP-176 AND THR-210
49.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210 AND THR-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
50.

"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."
Svendsen J.M. , Smogorzewska A. , Sowa M.E. , O'Connell B.C. , Gygi S.P. , Elledge S.J. , Harper J.W.
Cell138:63-77(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLX4
51.

"Plk1-mediated phosphorylation of Topors regulates p53 stability."
Yang X. , Li H. , Zhou Z. , Wang W.H. , Deng A. , Andrisani O. , Liu X.
J. Biol. Chem.284:18588-18592(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF TOPORS;INTERACTION WITH TOPORS
52.

"Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome."
Zhang X. , Chen Q. , Feng J. , Hou J. , Yang F. , Liu J. , Jiang Q. , Zhang C.
J. Cell Sci.122:2240-2251(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NEDD1 KINASE
53.

"Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a."
Jang C.Y. , Coppinger J.A. , Seki A. , Yates J.R. III , Fang G.
J. Cell Sci.122:1334-1341(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH KIF2A;SUBCELLULAR LOCATION
54.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210 AND THR-214;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
55.

"Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation."
Wolfe B.A. , Takaki T. , Petronczki M. , Glotzer M.
PLoS Biol.7:E1000110-E1000110(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RACGAP1;INTERACTION WITH PRC1;SUBCELLULAR LOCATION
56.

"Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells."
Burkard M.E. , Maciejowski J. , Rodriguez-Bravo V. , Repka M. , Lowery D.M. , Clauser K.R. , Zhang C. , Shokat K.M. , Carr S.A. , Yaffe M.B. , Jallepalli P.V.
PLoS Biol.7:E1000111-E1000111(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RACGAP1;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-67; LEU-130; HIS-538 AND LYS-540
57.

"Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy."
Strebhardt K.
Nat. Rev. Drug Discov.9:643-660(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;REVIEW ON ENZYME REGULATION
58.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
59.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
60.

"The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment."
Dunsch A.K. , Linnane E. , Barr F.A. , Gruneberg U.
J. Cell Biol.192:959-968(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH KNSTRN; SPAG5; DYNLL1 AND SGOL2
61.

"Furry protein promotes Aurora A-mediated polo-like kinase 1 activation."
Ikeda M. , Chiba S. , Ohashi K. , Mizuno K.
J. Biol. Chem.287:27670-27681(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FRY;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-194
62.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
63.

"Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit."
Yeh T.Y. , Kowalska A.K. , Scipioni B.R. , Cheong F.K. , Zheng M. , Derewenda U. , Derewenda Z.S. , Schroer T.A.
EMBO J.32:1023-1035(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCTN6;SUBCELLULAR LOCATION
64.

"MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression."
Zhu M. , Settele F. , Kotak S. , Sanchez-Pulido L. , Ehret L. , Ponting C.P. , Goenczy P. , Hoffmann I.
J. Cell Biol.200:773-787(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MISP
65.

"Ubiquitylation-dependent localization of PLK1 in mitosis."
Beck J. , Maerki S. , Posch M. , Metzger T. , Persaud A. , Scheel H. , Hofmann K. , Rotin D. , Pedrioli P. , Swedlow J.R. , Peter M. , Sumara I.
Nat. Cell Biol.15:430-439(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;UBIQUITINATION AT LYS-9 AND LYS-492;MUTAGENESIS OF LYS-492
66.

"The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain."
Elia A.E. , Rellos P. , Haire L.F. , Chao J.W. , Ivins F.J. , Hoepker K. , Mohammad D. , Cantley L.C. , Smerdon S.J. , Yaffe M.B.
Cell115:83-95(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 367-603 IN COMPLEX WITH PHOSPHORYLATED PEPTIDE;FUNCTION;SUBCELLULAR LOCATION;DOMAIN POLO BOX;INTERACTION WITH CDC25C;MUTAGENESIS OF HIS-538 AND LYS-540
67.

"The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex."
Cheng K.Y. , Lowe E.D. , Sinclair J. , Nigg E.A. , Johnson L.N.
EMBO J.22:5757-5768(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 367-603 IN COMPLEX WITH PHOSPHORYLATED PEPTIDE
68.

"Structure of the catalytic domain of human polo-like kinase 1."
Kothe M. , Kohls D. , Low S. , Coli R. , Cheng A.C. , Jacques S.L. , Johnson T.L. , Lewis C. , Loh C. , Nonomiya J. , Sheils A.L. , Verdries K.A. , Wynn T.A. , Kuhn C. , Ding Y.H.
Biochemistry46:5960-5971(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 13-345 OF MUTANT VAL-210 IN COMPLEXES WITH ATP ANALOGS;MUTAGENESIS OF THR-210
69.

"Selectivity-determining residues in Plk1."
Kothe M. , Kohls D. , Low S. , Coli R. , Rennie G.R. , Feru F. , Kuhn C. , Ding Y.H.
Chem. Biol. Drug Des.70:540-546(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 37-330 IN COMPLEX WITH SYNTHETIC INHIBITOR BI 2536
70.

"Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization."
Garcia-Alvarez B. , de Carcer G. , Ibanez S. , Bragado-Nilsson E. , Montoya G.
Proc. Natl. Acad. Sci. U.S.A.104:3107-3112(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 365-603 IN COMPLEX WITH CDC25C;SUBCELLULAR LOCATION;INTERACTION WITH CDC25C;ENZYME REGULATION;MUTAGENESIS OF TRP-414
71.

"Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin."
Bandeiras T.M. , Hillig R.C. , Matias P.M. , Eberspaecher U. , Fanghanel J. , Thomaz M. , Miranda S. , Crusius K. , Putter V. , Amstutz P. , Gulotti-Georgieva M. , Binz H.K. , Holz C. , Schmitz A.A. , Lang C. , Donner P. , Egner U. , Carrondo M.A. , more...
Acta Crystallogr. D64:339-353(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 33-345 IN COMPLEX WITH A DARPIN
72.

"Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1."
Yun S.M. , Moulaei T. , Lim D. , Bang J.K. , Park J.E. , Shenoy S.R. , Liu F. , Kang Y.H. , Liao C. , Soung N.K. , Lee S. , Yoon D.Y. , Lim Y. , Lee D.H. , Otaka A. , Appella E. , McMahon J.B. , Nicklaus M.C. , more...
Nat. Struct. Mol. Biol.16:876-882(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 371-603 IN COMPLEX WITH PHOSPHOPEPTIDE;FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PHOSPHORYLATED CENPU
73.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-12; PHE-261; VAL-332; HIS-463 AND HIS-518

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