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Index > Protein center > PLK2(Gene name) > Human
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  • PLK2 (Gene name),
  • Serine/threonine-protein kinase PLK2 (Protein name ),  PLK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PLK2(SNK);
    Protein name:
    Serine/threonine-protein kinase PLK2;
    Alternative:
    Serine/threonine-protein kinase SNK(hSNK);Polo-like kinase 2(PLK-2);Serum-inducible kinase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    685
    Sequence:
    50:
    MELLRTITYQ | PAASTKMCEQ | ALGKGCGADS | KKKRPPQPPE | ESQPPQSQAQ | 
    100:
    VPPAAPHHHH | HHSHSGPEIS | RIIVDPTTGK | RYCRGKVLGK | GGFAKCYEMT | 
    150:
    DLTNNKVYAA | KIIPHSRVAK | PHQREKIDKE | IELHRILHHK | HVVQFYHYFE | 
    200:
    DKENIYILLE | YCSRRSMAHI | LKARKVLTEP | EVRYYLRQIV | SGLKYLHEQE | 
    250:
    ILHRDLKLGN | FFINEAMELK | VGDFGLAARL | EPLEHRRRTI | CGTPNYLSPE | 
    300:
    VLNKQGHGCE | SDIWALGCVM | YTMLLGRPPF | ETTNLKETYR | CIREARYTMP | 
    350:
    SSLLAPAKHL | IASMLSKNPE | DRPSLDDIIR | HDFFLQGFTP | DRLSSSCCHT | 
    400:
    VPDFHLSSPA | KNFFKKAAAA | LFGGKKDKAR | YIDTHNRVSK | EDEDIYKLRH | 
    450:
    DLKKTSITQQ | PSKHRTDEEL | QPPTTTVARS | GTPAVENKQQ | IGDAIRMIVR | 
    500:
    GTLGSCSSSS | ECLEDSTMGS | VADTVARVLR | GCLENMPEAD | CIPKEQLSTS | 
    550:
    FQWVTKWVDY | SNKYGFGYQL | SDHTVGVLFN | NGAHMSLLPD | KKTVHYYAEL | 
    600:
    GQCSVFPATD | APEQFISQVT | VLKYFSHYME | ENLMDGGDLP | SVTDIRRPRL | 
    650:
    YLLQWLKSDK | ALMMLFNDGT | FQVNFYHDHT | KIIICSQNEE | YLLTYINEDR | 
    685:
    ISTTFRLTTL | LMSGCSSELK | NRMEYALNML | LQRCN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase PLK2
    Cat.:
    E12869m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Serine/threonine-protein kinase PLK2
    Cat.:
    E12869r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Serine/threonine-protein kinase PLK2
    Cat.:
    E12869h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Serine/threonine-protein kinase PLK2
    Cat.:
    U12869m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein kinase PLK2
    Cat.:
    U12869r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein kinase PLK2
    Cat.:
    U12869h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Serine/threonine-protein kinase PLK2
    Cat.:
    P12869Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serine/threonine-protein kinase PLK2
    Polyclonal Antibody for Human Serine/threonine-protein kinase PLK2
    Monoclonal Antibody for Human Serine/threonine-protein kinase PLK2
    Monoclonal Antibody for Human Serine/threonine-protein kinase PLK2
    Monoclonal Antibody for Human Serine/threonine-protein kinase PLK2
    Protein for Human Serine/threonine-protein kinase PLK2
    Cat.:
    R12869h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Serine/threonine-protein kinase PLK2
    Protein for Human Serine/threonine-protein kinase PLK2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase."
      Liby K. , Wu H. , Ouyang B. , Wu S. , Chen J. , Dai W.
      DNA Seq.11:527-533(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
    2. 2.
      "Identification and characterization of human serum-inducible kinase (SNK), a novel member of the polo-kinase family of cell cycle regulators: potential implication for regulation of vascular smooth muscle proliferation."
      Anderson K.M. , Nerurkar S.S. , Hansbury M.J. , Fornwald J. , Scott G. , Bouzyk M. , Mui P. , Imbrugia C.S. , Carlson K. , Marshall L.A. , Roshak A.K.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Colon.
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    4. 5.
      Fidler C. , Boultwood J. , Wang Jabs E. , Wainscoat J.S.
      Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 110-408
    5. 6.
      "Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells."
      Shimizu-Yoshida Y. , Sugiyama K. , Rogounovitch T. , Ohtsuru A. , Namba H. , Saenko V. , Yamashita S.
      Biochem. Biophys. Res. Commun.289:491-498(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    6. 7.
      "Polo-like kinase-2 is required for centriole duplication in mammalian cells."
      Warnke S. , Kemmler S. , Hames R.S. , Tsai H.L. , Hoffmann-Rohrer U. , Fry A.M. , Hoffmann I.
      Curr. Biol.14:1200-1207(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    7. 8.
      "Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies."
      Syed N. , Smith P. , Sullivan A. , Spender L.C. , Dyer M. , Karran L. , O'Nions J. , Allday M. , Hoffmann I. , Crawford D. , Griffin B. , Farrell P.J. , Crook T.
      Blood107:250-256(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOWN-REGULATION IN B-CELL LYMPHOMAS
    8. 9.
      "Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain."
      Cizmecioglu O. , Warnke S. , Arnold M. , Duensing S. , Hoffmann I.
      Cell Cycle7:3548-3555(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASN-210; TRP-503; HIS-629 AND LYS-631
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    10. 11.
      "PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle."
      Chang J. , Cizmecioglu O. , Hoffmann I. , Rhee K.
      EMBO J.29:2395-2406(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CENPJ
    11. 12.
      "Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication."
      Krause A. , Hoffmann I.
      PLoS ONE5:E9849-E9849(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF NPM
    12. 13.
      "Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions."
      Benetatos L. , Dasoula A. , Hatzimichael E. , Syed N. , Voukelatou M. , Dranitsaris G. , Bourantas K.L. , Crook T.
      Ann. Hematol.90:1037-1045(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOWN-REGULATION IN ACUTE MYELOID LEUKEMIA
    13. 14.
      "Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy."
      Strebhardt K.
      Nat. Rev. Drug Discov.9:643-660(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
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