Protein name:
Plasminogen ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (both mature PLG and the angiostatin peptide) with CSPG4 and AMOT. Interacts (via the Kringle domains) with HRG; the interaction tethers PLG to the cell surface and enhances its activation.
Function:
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
Subcellular Location:
Secreted
Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Protein Attributes:
50:
MEHKEVVLLL | LLFLKSGQGE | PLDDYVNTQG | ASLFSVTKKQ | LGAGSIEECA |
100:
AKCEEDEEFT | CRAFQYHSKE | QQCVIMAENR | KSSIIIRMRD | VVLFEKKVYL |
150:
SECKTGNGKN | YRGTMSKTKN | GITCQKWSST | SPHRPRFSPA | THPSEGLEEN |
200:
YCRNPDNDPQ | GPWCYTTDPE | KRYDYCDILE | CEEECMHCSG | ENYDGKISKT |
250:
MSGLECQAWD | SQSPHAHGYI | PSKFPNKNLK | KNYCRNPDRE | LRPWCFTTDP |
300:
NKRWELCDIP | RCTTPPPSSG | PTYQCLKGTG | ENYRGNVAVT | VSGHTCQHWS |
350:
AQTPHTHNRT | PENFPCKNLD | ENYCRNPDGK | RAPWCHTTNS | QVRWEYCKIP |
400:
SCDSSPVSTE | QLAPTAPPEL | TPVVQDCYHG | DGQSYRGTSS | TTTTGKKCQS |
450:
WSSMTPHRHQ | KTPENYPNAG | LTMNYCRNPD | ADKGPWCFTT | DPSVRWEYCN |
500:
LKKCSGTEAS | VVAPPPVVLL | PDVETPSEED | CMFGNGKGYR | GKRATTVTGT |
550:
PCQDWAAQEP | HRHSIFTPET | NPRAGLEKNY | CRNPDGDVGG | PWCYTTNPRK |
600:
LYDYCDVPQC | AAPSFDCGKP | QVEPKKCPGR | VVGGCVAHPH | SWPWQVSLRT |
650:
RFGMHFCGGT | LISPEWVLTA | AHCLEKSPRP | SSYKVILGAH | QEVNLEPHVQ |
700:
EIEVSRLFLE | PTRKDIALLK | LSSPAVITDK | VIPACLPSPN | YVVADRTECF |
750:
ITGWGETQGT | FGAGLLKEAQ | LPVIENKVCN | RYEFLNGRVQ | STELCAGHLA |
800:
GGTDSCQGDS | GGPLVCFEKD | KYILQGVTSW | GLGCARPNKP | GVYVRVSRFV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Dog
Pig
Rat
Mouse
ELISA Kit for Human Plasminogen
ELISA Kit for Human Plasminogen
ELISA Kit for Human Plasminogen
ELISA Kit for Human Plasminogen
ELISA Kit for Human Plasminogen
ELISA Kit for Human Plasminogen
CLIA Kit for Human Plasminogen
CLIA Kit for Human Plasminogen
CLIA Kit for Human Plasminogen
CLIA Kit for Human Plasminogen
CLIA Kit for Human Plasminogen
CLIA Kit for Human Plasminogen
Polyclonal Antibody for Human Plasminogen
Polyclonal Antibody for Human Plasminogen
Polyclonal Antibody for Human Plasminogen
Polyclonal Antibody for Human Plasminogen
Polyclonal Antibody for Human Plasminogen
Polyclonal Antibody for Human Plasminogen
Monoclonal Antibody for Human Plasminogen
Monoclonal Antibody for Human Plasminogen
Monoclonal Antibody for Human Plasminogen
Monoclonal Antibody for Human Plasminogen
Monoclonal Antibody for Human Plasminogen
Monoclonal Antibody for Human Plasminogen
Protein for Human Plasminogen
Protein for Human Plasminogen
Protein for Human Plasminogen
Protein for Human Plasminogen
Protein for Human Plasminogen
Protein for Human Plasminogen
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASN-472
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-57; GLN-133; HIS-261; TRP-408; ASN-472; VAL-494 AND TRP-523
5.
"The DNA sequence and analysis of human chromosome 6."
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more...
Nature425:805-811(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASP-676
tissue :
Kidney .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 20-810;VARIANT ASN-472
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 20-100
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 95-580; 581-626; 657-700 AND 732-810;VARIANT ASN-472
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 292-810
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 483-604
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 581-810
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVE SITE
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVE SITE
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : OMEGA-AMINOCARBOXYLIC ACID-BINDING SITES
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FIBRIN AND OMEGA-AMINOCARBOXYLIC ACID BINDING SITES
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-597
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT SER-268; ASN-308 AND THR-365;STRUCTURE OF CARBOHYDRATES
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HRG
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT SER-268
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF ANGIOSTATIN;PARTIAL PROTEIN SEQUENCE
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF ANGIOSTATIN
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC CLEAVAGE
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ATP5A1;SUBCELLULAR LOCATION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CSPG4;DOMAIN
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;ENZYME REGULATION;SUBCELLULAR LOCATION;FUNCTION OF PLASMIN;MUTAGENESIS OF SER-741
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH AMOT
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-308
tissue :
Milk .
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HRG
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 374-461
32.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 374-461
33.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 101-181
34.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 102-181
35.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 376-454
36.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 561-810;DISULFIDE BONDS
37.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.66 ANGSTROMS) OF 480-563
38.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 564-810;DISULFIDE BONDS
39.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 183-262
40.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 100-352;DISULFIDE BONDS
41.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 562-810
42.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 564-810
43.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.78 ANGSTROMS) OF 564-810 IN COMPLEX WITH THE SNAKE VENOM PROTEASE INHIBITOR TEXTILININ-1;DISULFIDE BOND
44.
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Cited for : STRUCTURE BY NMR OF 374-461
45.
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Cited for : STRUCTURE BY NMR OF 96-184
46.
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Cited for : STRUCTURE BY NMR OF 96-184
47.
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Cited for : STRUCTURE BY NMR OF 183-354
48.
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Cited for : STRUCTURE BY NMR OF 183-263
49.
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Cited for : VARIANTS PLGD PHE-374 AND THR-620
50.
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Cited for : ERRATUM
51.
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Cited for : VARIANT PLGD PRO-591
52.
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Cited for : VARIANT PLGD THR-620
53.
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Cited for : VARIANT PLGD THR-620
54.
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Cited for : VARIANT PLGD THR-620
55.
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Cited for : VARIANT PLGD HIS-235
56.
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Cited for : VARIANT PLGD ARG-751
57.
"Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis."
Schuster V.
,
Seidenspinner S.
,
Zeitler P.
,
Escher C.
,
Pleyer U.
,
Bernauer W.
,
Stiehm E.R.
,
Isenberg S.
,
Seregard S.
,
Olsson T.
,
Mingers A.-M.
,
Schambeck C.
,
Kreth H.W.
Blood93:3457-3466(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS PLGD GLU-38; PRO-147 AND HIS-532