PNPLA2 ELISA Kit for Human(Homo sapiens) | EIAab.comPNPLA2 ELISA Kit for Human(Homo sapiens)

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PNPLA2 (Gene name),

Patatin-like phospholipase domain-containing protein 2 (Protein name ), PLPL2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PNPLA2(FP17548;ATGL);

Protein name:

Patatin-like phospholipase domain-containing protein 2;

Alternative:

Calcium-independent phospholipase A2;Adipose triglyceride lipase;IPLA2-zeta;Desnutrin;TTS2.2;Pigment epithelium-derived factor;Transport-secretion protein 2(TTS2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity (By similarity). Interacts with SERPINF1; interacts at one site of interaction. Despite a colocalization in lipid droplets, it probably does not interact with PLIN.

Function:

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.

Subcellular Location:

Lipid droplet Cell membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

504

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

504:

ALGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01734

UniGene:

Hs.654697

String:

Q96AD5

STRING:

9606.ENSP00000337701

MIM:

609059

KEGG:

hsa:57104

Uniprot:

Q96AD5

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ELISA Kit for Human Patatin-like phospholipase domain-containing protein 2

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E8796h

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ELISA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

E8796r

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96T

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ELISA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

E8796m

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96T

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ELISA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

E8796b

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Packing:

96T

CLIA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796m

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Packing:

96T

CLIA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796b

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

U8796h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

P8796Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Patatin-like phospholipase domain-containing protein 2

Cat.:

P8796Rb-h

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Monoclonal Antibody for Human Patatin-like phospholipase domain-containing protein 2

Protein for Human Patatin-like phospholipase domain-containing protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase."
Zimmermann R. , Strauss J.G. , Haemmerle G. , Schoiswohl G. , Birner-Gruenberger R. , Riederer M. , Lass A. , Neuberger G. , Eisenhaber F. , Hermetter A. , Zechner R.
Science306:1383-1386(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
2.

"TTS-2, a novel protein implicated in vesicular transport of the cell surface receptor ICAM-3."
Strahl T. , Shingler W.H. , Lammiman M. , Gregory C.D. , Leach L. , Matthias P. , Nielsen P.J. , Shaw P.E.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT PRO-481
3.

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-481
tissue: Brain.
tissue: Eye.
5.

Yu W. , Gibbs R.A.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 94-504 (ISOFORM 1)
tissue: Brain.
6.

"Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities."
Jenkins C.M. , Mancuso D.J. , Yan W. , Sims H.F. , Gibson B. , Gross R.W.
J. Biol. Chem.279:48968-48975(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION
7.

"Adipocyte lipases and defect of lipolysis in human obesity."
Langin D. , Dicker A. , Tavernier G. , Hoffstedt J. , Mairal A. , Ryden M. , Arner E. , Sicard A. , Jenkins C.M. , Viguerie N. , van Harmelen V. , Gross R.W. , Holm C. , Arner P.
Diabetes54:3190-3197(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
8.

"Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members."
Lake A.C. , Sun Y. , Li J.-L. , Kim J.E. , Johnson J.W. , Li D. , Revett T. , Shih H.H. , Liu W. , Paulsen J.E. , Gimeno R.E.
J. Lipid Res.46:2477-2487(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;MUTAGENESIS OF SER-47
9.

"The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma."
Kim J.Y. , Tillison K. , Lee J.-H. , Rearick D.A. , Smas C.M.
Am. J. Physiol.291:E115-E127(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
10.

"ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells."
Smirnova E. , Goldberg E.B. , Makarova K.S. , Lin L. , Brown W.J. , Jackson C.L.
EMBO Rep.7:106-113(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-47
11.

"Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor."
Notari L. , Baladron V. , Aroca-Aguilar J.D. , Balko N. , Heredia R. , Meyer C. , Notario P.M. , Saravanamuthu S. , Nueda M.-L. , Sanchez-Sanchez F. , Escribano J. , Laborda J. , Becerra S.P.
J. Biol. Chem.281:38022-38037(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;INTERACTION WITH SERPINF1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase."
Pagnon J. , Matzaris M. , Stark R. , Meex R.C. , Macaulay S.L. , Brown W. , O'Brien P.E. , Tiganis T. , Watt M.J.
Endocrinology153:4278-4289(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-404
15.

"The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes."
Schoenborn V. , Heid I.M. , Vollmert C. , Lingenhel A. , Adams T.D. , Hopkins P.N. , Illig T. , Zimmermann R. , Zechner R. , Hunt S.C. , Kronenberg F.
Diabetes55:1270-1275(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHE-219; LYS-252 AND PRO-481;POLYMORPHISM;ASSOCIATION WITH DIABETES MELLITUS TYPE 2
16.

"The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy."
Fischer J. , Lefevre C. , Morava E. , Mussini J.-M. , Laforet P. , Negre-Salvayre A. , Lathrop M. , Salvayre R.
Nat. Genet.39:28-30(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NLSDM LEU-195

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